Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
Rotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must provide a temporal mechanical support during the healing process. In this work...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/184021 |
| Acceso en línea: | https://hdl.handle.net/2117/184021 https://dx.doi.org/10.1371/journal.pone.0224661 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomedical materials Materials biomèdics Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
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Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patchesRey Viñoles, Sergi|||0000-0002-2128-7704Castaño Linares, Óscar|||0000-0001-9212-784XRuiz Macarrilla, LeonardoLlorens, XavierMora Guix, José M.Engel López, Elisabeth|||0000-0003-4855-8874Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414Biomedical materialsMaterials biomèdicsÀrees temàtiques de la UPC::Enginyeria biomèdica::BiomaterialsRotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must provide a temporal mechanical support during the healing process. In this work, we proposed a simple method for the fabrication of synthetic RCA patches. This method combines the use of electrospraying to produce poly-L-lactic-co-e-caprolactone (PLC) films in an organogel form and electrospinning to produce poly(lactic) acid (PLA) nanofibers. The device consists in a combination of layers, creating a multilayered construct, enabling the possibility of tuning its mechanical properties and thickness. Besides, both techniques are simple to escalate for industrial production. A complete characterization has been performed to optimize the involved number of layers and production time of PLC films and PLA nanofibers fabrication, obtaining a final optimal configuration for RCA devices. Structural, mechanical and suture properties were evaluated. Also, the possibility of surface functionalization to improve the bioactivity of the scaffold was studied, adding aligned electrospun PLA nanofibers on the surface of the device to mimic the natural tendon topography. Surface modification was characterized by culturing adult normal human dermal fibroblasts. Lack of toxicity was detected for material presented, and cell alignment shape orientation guided by aligned fibers, mimicking tendon structure, was obtained. Cell proliferation and protein production were also evaluated.Peer ReviewedPublic Library of Science (PLOS)20192019-01-0120202020-04-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/184021https://dx.doi.org/10.1371/journal.pone.0224661reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1840212026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| title |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| spellingShingle |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches Rey Viñoles, Sergi|||0000-0002-2128-7704 Biomedical materials Materials biomèdics Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
| title_short |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| title_full |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| title_fullStr |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| title_full_unstemmed |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| title_sort |
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches |
| dc.creator.none.fl_str_mv |
Rey Viñoles, Sergi|||0000-0002-2128-7704 Castaño Linares, Óscar|||0000-0001-9212-784X Ruiz Macarrilla, Leonardo Llorens, Xavier Mora Guix, José M. Engel López, Elisabeth|||0000-0003-4855-8874 Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414 |
| author |
Rey Viñoles, Sergi|||0000-0002-2128-7704 |
| author_facet |
Rey Viñoles, Sergi|||0000-0002-2128-7704 Castaño Linares, Óscar|||0000-0001-9212-784X Ruiz Macarrilla, Leonardo Llorens, Xavier Mora Guix, José M. Engel López, Elisabeth|||0000-0003-4855-8874 Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414 |
| author_role |
author |
| author2 |
Castaño Linares, Óscar|||0000-0001-9212-784X Ruiz Macarrilla, Leonardo Llorens, Xavier Mora Guix, José M. Engel López, Elisabeth|||0000-0003-4855-8874 Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414 |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Biomedical materials Materials biomèdics Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
| topic |
Biomedical materials Materials biomèdics Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
| description |
Rotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must provide a temporal mechanical support during the healing process. In this work, we proposed a simple method for the fabrication of synthetic RCA patches. This method combines the use of electrospraying to produce poly-L-lactic-co-e-caprolactone (PLC) films in an organogel form and electrospinning to produce poly(lactic) acid (PLA) nanofibers. The device consists in a combination of layers, creating a multilayered construct, enabling the possibility of tuning its mechanical properties and thickness. Besides, both techniques are simple to escalate for industrial production. A complete characterization has been performed to optimize the involved number of layers and production time of PLC films and PLA nanofibers fabrication, obtaining a final optimal configuration for RCA devices. Structural, mechanical and suture properties were evaluated. Also, the possibility of surface functionalization to improve the bioactivity of the scaffold was studied, adding aligned electrospun PLA nanofibers on the surface of the device to mimic the natural tendon topography. Surface modification was characterized by culturing adult normal human dermal fibroblasts. Lack of toxicity was detected for material presented, and cell alignment shape orientation guided by aligned fibers, mimicking tendon structure, was obtained. Cell proliferation and protein production were also evaluated. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01 2020 2020-04-20 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/184021 https://dx.doi.org/10.1371/journal.pone.0224661 |
| url |
https://hdl.handle.net/2117/184021 https://dx.doi.org/10.1371/journal.pone.0224661 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science (PLOS) |
| publisher.none.fl_str_mv |
Public Library of Science (PLOS) |
| dc.source.none.fl_str_mv |
reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
| instname_str |
Universitat Politècnica de Catalunya (UPC) |
| reponame_str |
UPCommons. Portal del coneixement obert de la UPC |
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UPCommons. Portal del coneixement obert de la UPC |
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1869417250733162496 |
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15.300719 |