Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.

Brito, Marcelo A. M.; Baro, Barbara; Raiol, Tainá; Ayllon Hermida, Alberto; Safe, Izabella P.; Deroost, Katrien; Figueiredo, Erick F. G.; Costa, Allyson Guimarães; Armengol, Maria del Pilar; Sumoy, Lauro; Almeida, Anne C. G.; Hounkpe, Bidossessi W.; Paula, Erich V. de; Fernández Becerra, Carmen; Monteiro, Wuelton M.; Portillo Obando, Hernando A. del; Lacerda, Marcus V. G.

Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.

--- - Label: BACKGROUND NlmCategory: BACKGROUND content: The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a clinical case and experimental infections in splenectomized nonhuman primates unequivocally demonstrated the p...

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Autores:	Brito, Marcelo A. M., Baro, Barbara, Raiol, Tainá, Ayllon Hermida, Alberto, Safe, Izabella P., Deroost, Katrien, Figueiredo, Erick F. G., Costa, Allyson Guimarães, Armengol, Maria del Pilar, Sumoy, Lauro, Almeida, Anne C. G., Hounkpe, Bidossessi W., Paula, Erich V. de, Fernández Becerra, Carmen, Monteiro, Wuelton M., Portillo Obando, Hernando A. del, Lacerda, Marcus V. G.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/182852
Acceso en línea:	https://hdl.handle.net/2445/182852
Access Level:	acceso abierto
Palabra clave:	Medul·la òssia Malària Bone marrow Malaria

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spelling	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.Brito, Marcelo A. M.Baro, BarbaraRaiol, TaináAyllon Hermida, AlbertoSafe, Izabella P.Deroost, KatrienFigueiredo, Erick F. G.Costa, Allyson GuimarãesArmengol, Maria del PilarSumoy, LauroAlmeida, Anne C. G.Hounkpe, Bidossessi W.Paula, Erich V. deFernández Becerra, CarmenMonteiro, Wuelton M.Portillo Obando, Hernando A. delLacerda, Marcus V. G.Medul·la òssiaMalàriaBone marrowMalaria--- - Label: BACKGROUND NlmCategory: BACKGROUND content: The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a clinical case and experimental infections in splenectomized nonhuman primates unequivocally demonstrated the presence of parasites in this tissue. - Label: METHODS NlmCategory: METHODS content: In the current study, we analyzed BM aspirates of 7 patients during the acute attack and 42 days after drug treatment. RNA extracted from CD71+ cell suspensions was used for sequencing and transcriptomic analysis. - Label: RESULTS NlmCategory: RESULTS content: We demonstrated the presence of parasites in all patients during acute infections. To provide further insights, we purified CD71+ BM cells and demonstrated dyserythropoiesis and inefficient erythropoiesis in all patients. In addition, RNA sequencing from 3 patients showed that genes related to erythroid maturation were down-regulated during acute infections, whereas immune response genes were up-regulated. - Label: CONCLUSIONS NlmCategory: CONCLUSIONS content: This study thus shows that during P. vivax infections, parasites are always present in the BM and that such infections induced dyserythropoiesis and ineffective erythropoiesis. Moreover, infections induce transcriptional changes associated with such altered erythropoietic response, thus highlighting the importance of this hidden niche during natural infections.Oxford University Press2022202220202022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/182852Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1093/infdis/jiaa177Journal of Infectious Diseases, 2020http://dx.doi.org/ 10.1093/infdis/jiaa177cc by-nc-nd (c) Brito, Marcelo A. M. et al, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1828522026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
title	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
spellingShingle	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections. Brito, Marcelo A. M. Medul·la òssia Malària Bone marrow Malaria
title_short	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
title_full	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
title_fullStr	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
title_full_unstemmed	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
title_sort	Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.
dc.creator.none.fl_str_mv	Brito, Marcelo A. M. Baro, Barbara Raiol, Tainá Ayllon Hermida, Alberto Safe, Izabella P. Deroost, Katrien Figueiredo, Erick F. G. Costa, Allyson Guimarães Armengol, Maria del Pilar Sumoy, Lauro Almeida, Anne C. G. Hounkpe, Bidossessi W. Paula, Erich V. de Fernández Becerra, Carmen Monteiro, Wuelton M. Portillo Obando, Hernando A. del Lacerda, Marcus V. G.
author	Brito, Marcelo A. M.
author_facet	Brito, Marcelo A. M. Baro, Barbara Raiol, Tainá Ayllon Hermida, Alberto Safe, Izabella P. Deroost, Katrien Figueiredo, Erick F. G. Costa, Allyson Guimarães Armengol, Maria del Pilar Sumoy, Lauro Almeida, Anne C. G. Hounkpe, Bidossessi W. Paula, Erich V. de Fernández Becerra, Carmen Monteiro, Wuelton M. Portillo Obando, Hernando A. del Lacerda, Marcus V. G.
author_role	author
author2	Baro, Barbara Raiol, Tainá Ayllon Hermida, Alberto Safe, Izabella P. Deroost, Katrien Figueiredo, Erick F. G. Costa, Allyson Guimarães Armengol, Maria del Pilar Sumoy, Lauro Almeida, Anne C. G. Hounkpe, Bidossessi W. Paula, Erich V. de Fernández Becerra, Carmen Monteiro, Wuelton M. Portillo Obando, Hernando A. del Lacerda, Marcus V. G.
author2_role	author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Medul·la òssia Malària Bone marrow Malaria
topic	Medul·la òssia Malària Bone marrow Malaria
description	--- - Label: BACKGROUND NlmCategory: BACKGROUND content: The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a clinical case and experimental infections in splenectomized nonhuman primates unequivocally demonstrated the presence of parasites in this tissue. - Label: METHODS NlmCategory: METHODS content: In the current study, we analyzed BM aspirates of 7 patients during the acute attack and 42 days after drug treatment. RNA extracted from CD71+ cell suspensions was used for sequencing and transcriptomic analysis. - Label: RESULTS NlmCategory: RESULTS content: We demonstrated the presence of parasites in all patients during acute infections. To provide further insights, we purified CD71+ BM cells and demonstrated dyserythropoiesis and inefficient erythropoiesis in all patients. In addition, RNA sequencing from 3 patients showed that genes related to erythroid maturation were down-regulated during acute infections, whereas immune response genes were up-regulated. - Label: CONCLUSIONS NlmCategory: CONCLUSIONS content: This study thus shows that during P. vivax infections, parasites are always present in the BM and that such infections induced dyserythropoiesis and ineffective erythropoiesis. Moreover, infections induce transcriptional changes associated with such altered erythropoietic response, thus highlighting the importance of this hidden niche during natural infections.
publishDate	2020
dc.date.none.fl_str_mv	2020 2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/182852
url	https://hdl.handle.net/2445/182852
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: http://dx.doi.org/10.1093/infdis/jiaa177 Journal of Infectious Diseases, 2020 http://dx.doi.org/ 10.1093/infdis/jiaa177
dc.rights.none.fl_str_mv	cc by-nc-nd (c) Brito, Marcelo A. M. et al, 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by-nc-nd (c) Brito, Marcelo A. M. et al, 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	10 p. application/pdf application/pdf
dc.publisher.none.fl_str_mv	Oxford University Press
publisher.none.fl_str_mv	Oxford University Press
dc.source.none.fl_str_mv	Articles publicats en revistes (ISGlobal) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.

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