Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review

Nanotechnology has revolutionized novel drug delivery strategies through establishing nanoscale drug carriers, such as niosomes, liposomes, nanomicelles, dendrimers, polymeric micelles, and nanoparticles (NPs). Owing to their desirable cancer-targeting efficacy and controlled release, these nanother...

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Detalles Bibliográficos
Autores: Sargazi, Saman, Rahdar, Abbas, Barani, Mahmood, Pandey, Sadanand, Díez Pascual, Ana María|||0000-0001-7405-2354
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/50162
Acceso en línea:http://hdl.handle.net/10017/50162
https://dx.doi.org/10.3390/ijms221910319
Access Level:acceso abierto
Palabra clave:Nanotechnology
Nanomaterials
DNA repairPoly(ADP-ribose) polymerasesPARP inhibitors
Targeted treatment
Drug resistance mechanism
Toxicity
Química
Chemistry
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spelling Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary ReviewSargazi, SamanRahdar, AbbasBarani, MahmoodPandey, SadanandDíez Pascual, Ana María|||0000-0001-7405-2354NanotechnologyNanomaterialsDNA repairPoly(ADP-ribose) polymerasesPARP inhibitorsTargeted treatmentDrug resistance mechanismToxicityQuímicaChemistryNanotechnology has revolutionized novel drug delivery strategies through establishing nanoscale drug carriers, such as niosomes, liposomes, nanomicelles, dendrimers, polymeric micelles, and nanoparticles (NPs). Owing to their desirable cancer-targeting efficacy and controlled release, these nanotherapeutic modalities are broadly used in clinics to improve the efficacy of small-molecule inhibitors. Poly(ADP-ribose) polymerase (PARP) family members engage in various intracellular processes, including DNA repair, gene transcription, signal transduction, cell cycle regulation, cell division, and antioxidant response. PARP inhibitors are synthetic small-molecules that have emerged as one of the most successful innovative strategies for targeted therapy in cancer cells harboring mutations in DNA repair genes. Despite these advances, drug resistance and unwanted side effects are two significant drawbacks to using PARP inhibitors in the clinic. Recently, the development of practical nanotechnology-based drug delivery systems has tremendously improved the efficacy of PARP inhibitors. NPs can specifically accumulate in the leaky vasculature of the tumor and cancer cells and release the chemotherapeutic moiety in the tumor microenvironment. On the contrary, NPs are usually unable to permeate across the body's normal organs and tissues; hence the toxicity is zero to none. NPs can modify the release of encapsulated drugs based on the composition of the coating substance. Delivering PARP inhibitors without modulation often leads to the toxic effect; therefore, a delivery vehicle is essential to encapsulate them. Various nanocarriers have been exploited to deliver PARP inhibitors in different cancers. Through this review, we hope to cast light on the most innovative advances in applying PARP inhibitors for therapeutic purposes.Comunidad de Madrid20212021-09-25journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/50162https://dx.doi.org/10.3390/ijms221910319reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengComunidad de Madrid http://dx.doi.org/10.13039/100012818 Estímulo a la Excelencia para Profesores Universitarios Permanentes EPU-INV%2F2020%2F012open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/501622026-06-18T11:13:07Z
dc.title.none.fl_str_mv Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
title Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
spellingShingle Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
Sargazi, Saman
Nanotechnology
Nanomaterials
DNA repairPoly(ADP-ribose) polymerasesPARP inhibitors
Targeted treatment
Drug resistance mechanism
Toxicity
Química
Chemistry
title_short Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
title_full Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
title_fullStr Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
title_full_unstemmed Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
title_sort Active Targeted of Nanoparticles for Delivery of Poly(ADP ribose) Polymerase (PARP) Inhibitors: A Preliminary Review
dc.creator.none.fl_str_mv Sargazi, Saman
Rahdar, Abbas
Barani, Mahmood
Pandey, Sadanand
Díez Pascual, Ana María|||0000-0001-7405-2354
author Sargazi, Saman
author_facet Sargazi, Saman
Rahdar, Abbas
Barani, Mahmood
Pandey, Sadanand
Díez Pascual, Ana María|||0000-0001-7405-2354
author_role author
author2 Rahdar, Abbas
Barani, Mahmood
Pandey, Sadanand
Díez Pascual, Ana María|||0000-0001-7405-2354
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nanotechnology
Nanomaterials
DNA repairPoly(ADP-ribose) polymerasesPARP inhibitors
Targeted treatment
Drug resistance mechanism
Toxicity
Química
Chemistry
topic Nanotechnology
Nanomaterials
DNA repairPoly(ADP-ribose) polymerasesPARP inhibitors
Targeted treatment
Drug resistance mechanism
Toxicity
Química
Chemistry
description Nanotechnology has revolutionized novel drug delivery strategies through establishing nanoscale drug carriers, such as niosomes, liposomes, nanomicelles, dendrimers, polymeric micelles, and nanoparticles (NPs). Owing to their desirable cancer-targeting efficacy and controlled release, these nanotherapeutic modalities are broadly used in clinics to improve the efficacy of small-molecule inhibitors. Poly(ADP-ribose) polymerase (PARP) family members engage in various intracellular processes, including DNA repair, gene transcription, signal transduction, cell cycle regulation, cell division, and antioxidant response. PARP inhibitors are synthetic small-molecules that have emerged as one of the most successful innovative strategies for targeted therapy in cancer cells harboring mutations in DNA repair genes. Despite these advances, drug resistance and unwanted side effects are two significant drawbacks to using PARP inhibitors in the clinic. Recently, the development of practical nanotechnology-based drug delivery systems has tremendously improved the efficacy of PARP inhibitors. NPs can specifically accumulate in the leaky vasculature of the tumor and cancer cells and release the chemotherapeutic moiety in the tumor microenvironment. On the contrary, NPs are usually unable to permeate across the body's normal organs and tissues; hence the toxicity is zero to none. NPs can modify the release of encapsulated drugs based on the composition of the coating substance. Delivering PARP inhibitors without modulation often leads to the toxic effect; therefore, a delivery vehicle is essential to encapsulate them. Various nanocarriers have been exploited to deliver PARP inhibitors in different cancers. Through this review, we hope to cast light on the most innovative advances in applying PARP inhibitors for therapeutic purposes.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-09-25
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/50162
https://dx.doi.org/10.3390/ijms221910319
url http://hdl.handle.net/10017/50162
https://dx.doi.org/10.3390/ijms221910319
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Estímulo a la Excelencia para Profesores Universitarios Permanentes EPU-INV%2F2020%2F012
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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