Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus

Gut microbiota plays an important role in the regulation of the immune system and host’s metabolism. We aimed to characterize the gut microbiota of Tunisian participants with and without diabetes. We enrolled ten participants with type 1 diabetes mellitus (T1DM), ten patients with type 2 diabetes me...

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Authors: Fassatou, Meriem, López Siles, Mireia, Díaz Rizzolo, Diana A., Jmel, Haifa, Naouali, Chokri, Abdessalem, Ghaith, Chikhaou, Asma, Nadal, Belén, Jamoussi, Henda, Abid, Abdelmajid, Gomis, Ramon, Abdelhak, Sonia, Martínez Medina, Margarita, Kefi, Rym
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/18216
Online Access:http://hdl.handle.net/10256/18216
Access Level:Open access
Keyword:Intestins -- Microbiologia
Intestines -- Microbiology
Diabetis
Diabetes
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spelling Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitusFassatou, MeriemLópez Siles, MireiaDíaz Rizzolo, Diana A.Jmel, HaifaNaouali, ChokriAbdessalem, GhaithChikhaou, AsmaNadal, BelénJamoussi, HendaAbid, AbdelmajidGomis, RamonAbdelhak, SoniaMartínez Medina, MargaritaKefi, RymIntestins -- MicrobiologiaIntestines -- MicrobiologyDiabetisDiabetesGut microbiota plays an important role in the regulation of the immune system and host’s metabolism. We aimed to characterize the gut microbiota of Tunisian participants with and without diabetes. We enrolled ten participants with type 1 diabetes mellitus (T1DM), ten patients with type 2 diabetes mellitus (T2DM), and 11 subjects without diabetes. Bacteria was quantified in fecal samples by quantitative PCR (qPCR). Statistical tests and multivariate analysis were performed using RStudio program. Results showed that the proportions of Firmicutes, Akkermansia muciniphila, and Faecalibacterium prausnitzii (P≤0.041), as well as, the ratio Firmicutes/Bacteroidetes decreased in participants with T1DM compared with those without diabetes (p = 0.036). Participants with T2DM presented a reduction in the amounts of A. muciniphila and F. prausnitzii compared with those without diabetes (P≤0.036). Furthermore, A muciniphila is negatively correlated with glucose level (P=0.022) and glycated hemoglobin (HbA1c) (P=0.035). Multivariate analysis revealed that participants with diabetes formed a cluster apart compared with those without diabetes. In conclusion the gut bacteria of Tunisian participants with diabetes was altered. The gut bacterial profile, especially the distribution of A muciniphila in participants with diabetes was affected by glycemic dysregulation. The investigation of the gut microbiota may help clinicians to improve diagnosis and treatment of diabetes and its complicationsThis work was supported in part by the Ministry of Higher Education and Scientific Research [grant number LR11IPT05]; the Universitat de Girona Project [grant number MPCUdG2016-009] and the Spanish Ministry of Education and Science Project [grant number SAF2013-43284-P]Biochemical SocietyMinisterio de Economía y Competitividad (Espanya)2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/18216http://hdl.handle.net/10256/18216Bioscience Reports, 2019, vol. 39, núm. 6, p. BSR20182348Articles publicats (D-B)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1042/BSR20182348info:eu-repo/semantics/altIdentifier/issn/0144-8463info:eu-repo/semantics/altIdentifier/eissn/1573-4935info:eu-repo/grantAgreement/MINECO//SAF2013-43284-PAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/182162026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
title Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
spellingShingle Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
Fassatou, Meriem
Intestins -- Microbiologia
Intestines -- Microbiology
Diabetis
Diabetes
title_short Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
title_full Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
title_fullStr Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
title_full_unstemmed Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
title_sort Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus
dc.creator.none.fl_str_mv Fassatou, Meriem
López Siles, Mireia
Díaz Rizzolo, Diana A.
Jmel, Haifa
Naouali, Chokri
Abdessalem, Ghaith
Chikhaou, Asma
Nadal, Belén
Jamoussi, Henda
Abid, Abdelmajid
Gomis, Ramon
Abdelhak, Sonia
Martínez Medina, Margarita
Kefi, Rym
author Fassatou, Meriem
author_facet Fassatou, Meriem
López Siles, Mireia
Díaz Rizzolo, Diana A.
Jmel, Haifa
Naouali, Chokri
Abdessalem, Ghaith
Chikhaou, Asma
Nadal, Belén
Jamoussi, Henda
Abid, Abdelmajid
Gomis, Ramon
Abdelhak, Sonia
Martínez Medina, Margarita
Kefi, Rym
author_role author
author2 López Siles, Mireia
Díaz Rizzolo, Diana A.
Jmel, Haifa
Naouali, Chokri
Abdessalem, Ghaith
Chikhaou, Asma
Nadal, Belén
Jamoussi, Henda
Abid, Abdelmajid
Gomis, Ramon
Abdelhak, Sonia
Martínez Medina, Margarita
Kefi, Rym
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (Espanya)
dc.subject.none.fl_str_mv Intestins -- Microbiologia
Intestines -- Microbiology
Diabetis
Diabetes
topic Intestins -- Microbiologia
Intestines -- Microbiology
Diabetis
Diabetes
description Gut microbiota plays an important role in the regulation of the immune system and host’s metabolism. We aimed to characterize the gut microbiota of Tunisian participants with and without diabetes. We enrolled ten participants with type 1 diabetes mellitus (T1DM), ten patients with type 2 diabetes mellitus (T2DM), and 11 subjects without diabetes. Bacteria was quantified in fecal samples by quantitative PCR (qPCR). Statistical tests and multivariate analysis were performed using RStudio program. Results showed that the proportions of Firmicutes, Akkermansia muciniphila, and Faecalibacterium prausnitzii (P≤0.041), as well as, the ratio Firmicutes/Bacteroidetes decreased in participants with T1DM compared with those without diabetes (p = 0.036). Participants with T2DM presented a reduction in the amounts of A. muciniphila and F. prausnitzii compared with those without diabetes (P≤0.036). Furthermore, A muciniphila is negatively correlated with glucose level (P=0.022) and glycated hemoglobin (HbA1c) (P=0.035). Multivariate analysis revealed that participants with diabetes formed a cluster apart compared with those without diabetes. In conclusion the gut bacteria of Tunisian participants with diabetes was altered. The gut bacterial profile, especially the distribution of A muciniphila in participants with diabetes was affected by glycemic dysregulation. The investigation of the gut microbiota may help clinicians to improve diagnosis and treatment of diabetes and its complications
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/18216
http://hdl.handle.net/10256/18216
url http://hdl.handle.net/10256/18216
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1042/BSR20182348
info:eu-repo/semantics/altIdentifier/issn/0144-8463
info:eu-repo/semantics/altIdentifier/eissn/1573-4935
info:eu-repo/grantAgreement/MINECO//SAF2013-43284-P
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biochemical Society
publisher.none.fl_str_mv Biochemical Society
dc.source.none.fl_str_mv Bioscience Reports, 2019, vol. 39, núm. 6, p. BSR20182348
Articles publicats (D-B)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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