A Study of the Relationship Between Objective Tests to Diagnose Erectile Dysfunction and Markers of Cardiovascular Disease

Background: Erectile dysfunction (ED) can stem from various organic and functional causes but is often linked to vascular health and cardiovascular disease. Limited data exist on how cardiovascular disease markers correlate with objective ED tests like the Nocturnal Penile Tumescence and Rigidity (N...

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Detalles Bibliográficos
Autores: De Rocco Ponce, Maurizio|||0000-0002-0821-3591, Quintian Schwieters, Claudia Fabiana|||0000-0002-3646-2886, Meziere, Juliette, Sánchez-Curbelo, Josvany|||0000-0002-6489-3309, Abad Carratalá, Guillem|||0000-0001-9908-5953, Troka, Eden, Bassas, Lluís|||0000-0002-3473-3611, Ruiz-Castañé, Eduardo|||0000-0002-7469-4610, Martinez Barcina, Maria José, Rajmil Marquenson, Osvlado|||0000-0003-1987-9206
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:304214
Acceso en línea:https://ddd.uab.cat/record/304214
https://dx.doi.org/urn:doi:10.3390/jcm13216321
Access Level:acceso abierto
Palabra clave:Erectile dysfunction
Penile Color Doppler Ultrasound
Nocturnal Penile Tumescence and Rigidity test
Descripción
Sumario:Background: Erectile dysfunction (ED) can stem from various organic and functional causes but is often linked to vascular health and cardiovascular disease. Limited data exist on how cardiovascular disease markers correlate with objective ED tests like the Nocturnal Penile Tumescence and Rigidity (NPTR) test and Penile Color Doppler Ultrasound (PCDU). Methods : A prospective observational study was performed, and 58 men with ED were assessed using the International Index of Erectile Function-15 (IIEF-15), NPTR test, and PCDU. Peripheral vascular health was evaluated through carotid intima-media thickness (cIMT) and brachial flow-mediated dilation (FMD). Results: Out of the participants, 44 had normal NPTR results, while 14 had abnormal results. The group with abnormal NPTR results was significantly older and had higher rates of hypertension and diabetes. Although the IIEF-15 scores were similar between the two groups, those with abnormal NPTR results had a lower peak systolic velocity (PSV) and a higher prevalence of impaired PSV. Correlations between the IIEF, NPTR, PCDU, and peripheral vascular markers lost significance after the age adjustment. Conclusions: This study suggests that abnormal NPTR results, combined with cardiovascular risk factors, may signal vascular ED and generalized vasculopathy, highlighting the need for cardiovascular assessment. An accurate ED diagnosis should integrate clinical evaluation with multiple tests while considering aging as a key risk factor.

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