The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging

Introduction: An unwanted consequence of population aging is the growing number of elderly at risk of neurodegenerative disorders, including dementia and macular degeneration. As nutritional and behavioral changes can delay disease progression, we designed the Walnuts and Healthy Aging (WAHA) study,...

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Autores: Rajaram, Sujatha, Valls Pedret, Cinta, Cofán Pujol, Montserrat, Sabaté, Joan, Serra-Mir, Mercè, Pérez-Heras, Ana Maria, Arechiga, Adam, Casaroli Marano, Ricardo Pedro, Alforja, Socorro, Sala Vila, Aleix, Doménech, Mónica, Roth, Irene, Freitas Simoes, Tania M., Calvo, Carlos, López Illamola, Anna, Haddad, Ella, Kazzi, Natalie, Huey, Lynnley, Fan, Joseph, Bitok, Edward, Ros Rahola, Emilio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/120841
Acceso en línea:https://hdl.handle.net/2445/120841
Access Level:acceso abierto
Palabra clave:Malalties neurodegeneratives
Demència senil
Neurodegenerative Diseases
Senile dementia
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spelling The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain AgingRajaram, SujathaValls Pedret, CintaCofán Pujol, MontserratSabaté, JoanSerra-Mir, MercèPérez-Heras, Ana MariaArechiga, AdamCasaroli Marano, Ricardo PedroAlforja, SocorroSala Vila, AleixDoménech, MónicaRoth, IreneFreitas Simoes, Tania M.Calvo, CarlosLópez Illamola, AnnaHaddad, EllaKazzi, NatalieHuey, LynnleyFan, JosephBitok, EdwardRos Rahola, EmilioMalalties neurodegenerativesDemència senilNeurodegenerative DiseasesSenile dementiaIntroduction: An unwanted consequence of population aging is the growing number of elderly at risk of neurodegenerative disorders, including dementia and macular degeneration. As nutritional and behavioral changes can delay disease progression, we designed the Walnuts and Healthy Aging (WAHA) study, a two-center, randomized, 2-year clinical trial conducted in free-living, cognitively healthy elderly men and women. Our interest in exploring the role of walnuts in maintaining cognitive and retinal health is based on extensive evidence supporting their cardio-protective and vascular health effects, which are linked to bioactive components, such as n-3 fatty acids and polyphenols. Methods: The primary aim of WAHA is to examine the effects of ingesting walnuts daily for 2 years on cognitive function and retinal health, assessed with a battery of neuropsychological tests and optical coherence tomography, respectively. All participants followed their habitual diet, adding walnuts at 15% of energy (≈30-60 g/day) (walnut group) or abstaining from walnuts (control group). Secondary outcomes include changes in adiposity, blood pressure, and serum and urinary biomarkers in all participants and brain magnetic resonance imaging in a subset. Results: From May 2012 to May 2014, 708 participants (mean age 69 years, 68% women) were randomized. The study ended in May 2016 with a 90% retention rate. Discussion: The results of WAHA might provide high-level evidence of the benefit of regular walnut consumption in delaying the onset of age-related cognitive impairment and retinal pathology. The findings should translate into public health policy and sound recommendations to the general population.Frontiers Media2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/120841Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2016.00333Frontiers in Aging Neuroscience, 2017, vol. 8, num. 333https://doi.org/10.3389/fnagi.2016.00333cc-by (c) Rajaram et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1208412026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
title The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
spellingShingle The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
Rajaram, Sujatha
Malalties neurodegeneratives
Demència senil
Neurodegenerative Diseases
Senile dementia
title_short The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
title_full The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
title_fullStr The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
title_full_unstemmed The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
title_sort The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging
dc.creator.none.fl_str_mv Rajaram, Sujatha
Valls Pedret, Cinta
Cofán Pujol, Montserrat
Sabaté, Joan
Serra-Mir, Mercè
Pérez-Heras, Ana Maria
Arechiga, Adam
Casaroli Marano, Ricardo Pedro
Alforja, Socorro
Sala Vila, Aleix
Doménech, Mónica
Roth, Irene
Freitas Simoes, Tania M.
Calvo, Carlos
López Illamola, Anna
Haddad, Ella
Kazzi, Natalie
Huey, Lynnley
Fan, Joseph
Bitok, Edward
Ros Rahola, Emilio
author Rajaram, Sujatha
author_facet Rajaram, Sujatha
Valls Pedret, Cinta
Cofán Pujol, Montserrat
Sabaté, Joan
Serra-Mir, Mercè
Pérez-Heras, Ana Maria
Arechiga, Adam
Casaroli Marano, Ricardo Pedro
Alforja, Socorro
Sala Vila, Aleix
Doménech, Mónica
Roth, Irene
Freitas Simoes, Tania M.
Calvo, Carlos
López Illamola, Anna
Haddad, Ella
Kazzi, Natalie
Huey, Lynnley
Fan, Joseph
Bitok, Edward
Ros Rahola, Emilio
author_role author
author2 Valls Pedret, Cinta
Cofán Pujol, Montserrat
Sabaté, Joan
Serra-Mir, Mercè
Pérez-Heras, Ana Maria
Arechiga, Adam
Casaroli Marano, Ricardo Pedro
Alforja, Socorro
Sala Vila, Aleix
Doménech, Mónica
Roth, Irene
Freitas Simoes, Tania M.
Calvo, Carlos
López Illamola, Anna
Haddad, Ella
Kazzi, Natalie
Huey, Lynnley
Fan, Joseph
Bitok, Edward
Ros Rahola, Emilio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties neurodegeneratives
Demència senil
Neurodegenerative Diseases
Senile dementia
topic Malalties neurodegeneratives
Demència senil
Neurodegenerative Diseases
Senile dementia
description Introduction: An unwanted consequence of population aging is the growing number of elderly at risk of neurodegenerative disorders, including dementia and macular degeneration. As nutritional and behavioral changes can delay disease progression, we designed the Walnuts and Healthy Aging (WAHA) study, a two-center, randomized, 2-year clinical trial conducted in free-living, cognitively healthy elderly men and women. Our interest in exploring the role of walnuts in maintaining cognitive and retinal health is based on extensive evidence supporting their cardio-protective and vascular health effects, which are linked to bioactive components, such as n-3 fatty acids and polyphenols. Methods: The primary aim of WAHA is to examine the effects of ingesting walnuts daily for 2 years on cognitive function and retinal health, assessed with a battery of neuropsychological tests and optical coherence tomography, respectively. All participants followed their habitual diet, adding walnuts at 15% of energy (≈30-60 g/day) (walnut group) or abstaining from walnuts (control group). Secondary outcomes include changes in adiposity, blood pressure, and serum and urinary biomarkers in all participants and brain magnetic resonance imaging in a subset. Results: From May 2012 to May 2014, 708 participants (mean age 69 years, 68% women) were randomized. The study ended in May 2016 with a 90% retention rate. Discussion: The results of WAHA might provide high-level evidence of the benefit of regular walnut consumption in delaying the onset of age-related cognitive impairment and retinal pathology. The findings should translate into public health policy and sound recommendations to the general population.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120841
url https://hdl.handle.net/2445/120841
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2016.00333
Frontiers in Aging Neuroscience, 2017, vol. 8, num. 333
https://doi.org/10.3389/fnagi.2016.00333
dc.rights.none.fl_str_mv cc-by (c) Rajaram et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rajaram et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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