Molecular links between early energy metabolism alterations and Alzheimer´s disease

Recent studies suggest that the neurobiology of Alzheimer's disease (AD) pathology could not be explained solely by an increase in beta-amyloid levels. In fact, success with potential therapeutic drugs that inhibit the generation of beta amyloid has been low. Therefore, due to therapeutic failu...

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Autores: Pedros, Ignacio, Patraca, Ivan, Martínez, Naroa, Petrov, Dmitry, Sureda, Francesc X., Auladell i Costa, M. Carme, Beas Zárate, Carlos, Folch, Jaume
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/138560
Acceso en línea:https://hdl.handle.net/2445/138560
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Metabolisme energètic
Alzheimer's disease
Energy metabolism
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spelling Molecular links between early energy metabolism alterations and Alzheimer´s diseasePedros, IgnacioPatraca, IvanMartínez, NaroaPetrov, DmitrySureda, Francesc X.Auladell i Costa, M. CarmeBeas Zárate, CarlosFolch, JaumeMalaltia d'AlzheimerMetabolisme energèticAlzheimer's diseaseEnergy metabolismRecent studies suggest that the neurobiology of Alzheimer's disease (AD) pathology could not be explained solely by an increase in beta-amyloid levels. In fact, success with potential therapeutic drugs that inhibit the generation of beta amyloid has been low. Therefore, due to therapeutic failure in recent years, the scientists are looking for alternative hypotheses to explain the causes of the disease and the cognitive loss. Accordingly, alternative hypothesis propose a link between AD and peripheral metabolic alteration. Then, we review in depth changes related to insulin signalling and energy metabolism in the context of the APPSwe/PS1dE9 (APP/PS1) mice model of AD. We show an integrated view of the changes that occur in the early stages of the amyloidogenic process in the APP/PS1 double transgenic mice model. These early changes affect several key metabolic processes related to glucose uptake and insulin signalling, cellular energy homeostasis, mitochondrial biogenesis and increased Tau phosphorylation by kinase molecules like mTOR and Cdk5.Frontiers in Bioscience2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/138560Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.2741/4372Frontiers in Bioscience-Landmark Edition, 2016, vol. 1, num. 21, p. 8-19https://doi.org/10.2741/4372(c) Frontiers in Bioscience, 2016info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1385602026-05-27T06:46:51Z
dc.title.none.fl_str_mv Molecular links between early energy metabolism alterations and Alzheimer´s disease
title Molecular links between early energy metabolism alterations and Alzheimer´s disease
spellingShingle Molecular links between early energy metabolism alterations and Alzheimer´s disease
Pedros, Ignacio
Malaltia d'Alzheimer
Metabolisme energètic
Alzheimer's disease
Energy metabolism
title_short Molecular links between early energy metabolism alterations and Alzheimer´s disease
title_full Molecular links between early energy metabolism alterations and Alzheimer´s disease
title_fullStr Molecular links between early energy metabolism alterations and Alzheimer´s disease
title_full_unstemmed Molecular links between early energy metabolism alterations and Alzheimer´s disease
title_sort Molecular links between early energy metabolism alterations and Alzheimer´s disease
dc.creator.none.fl_str_mv Pedros, Ignacio
Patraca, Ivan
Martínez, Naroa
Petrov, Dmitry
Sureda, Francesc X.
Auladell i Costa, M. Carme
Beas Zárate, Carlos
Folch, Jaume
author Pedros, Ignacio
author_facet Pedros, Ignacio
Patraca, Ivan
Martínez, Naroa
Petrov, Dmitry
Sureda, Francesc X.
Auladell i Costa, M. Carme
Beas Zárate, Carlos
Folch, Jaume
author_role author
author2 Patraca, Ivan
Martínez, Naroa
Petrov, Dmitry
Sureda, Francesc X.
Auladell i Costa, M. Carme
Beas Zárate, Carlos
Folch, Jaume
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Metabolisme energètic
Alzheimer's disease
Energy metabolism
topic Malaltia d'Alzheimer
Metabolisme energètic
Alzheimer's disease
Energy metabolism
description Recent studies suggest that the neurobiology of Alzheimer's disease (AD) pathology could not be explained solely by an increase in beta-amyloid levels. In fact, success with potential therapeutic drugs that inhibit the generation of beta amyloid has been low. Therefore, due to therapeutic failure in recent years, the scientists are looking for alternative hypotheses to explain the causes of the disease and the cognitive loss. Accordingly, alternative hypothesis propose a link between AD and peripheral metabolic alteration. Then, we review in depth changes related to insulin signalling and energy metabolism in the context of the APPSwe/PS1dE9 (APP/PS1) mice model of AD. We show an integrated view of the changes that occur in the early stages of the amyloidogenic process in the APP/PS1 double transgenic mice model. These early changes affect several key metabolic processes related to glucose uptake and insulin signalling, cellular energy homeostasis, mitochondrial biogenesis and increased Tau phosphorylation by kinase molecules like mTOR and Cdk5.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/138560
url https://hdl.handle.net/2445/138560
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.2741/4372
Frontiers in Bioscience-Landmark Edition, 2016, vol. 1, num. 21, p. 8-19
https://doi.org/10.2741/4372
dc.rights.none.fl_str_mv (c) Frontiers in Bioscience, 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Frontiers in Bioscience, 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience
publisher.none.fl_str_mv Frontiers in Bioscience
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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