Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome

Objective: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). Methods: Twenty-one genetically-confirmed PWS patients, 30 age-...

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Autores: Blanco-Hinojo, L, Pujol, J, Esteba-Castillo, S, Martinez-Vilavella, G, Gimenez-Palop, O, Gabau, E, Casamitjana, L, Deus, J, Novell, R, Caixas, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p3090
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/3090
Access Level:acceso abierto
Palabra clave:Prader Willi syndrome
Functional MRI
Disgust
Hypothalamus
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spelling Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndromeBlanco-Hinojo, LPujol, JEsteba-Castillo, SMartinez-Vilavella, GGimenez-Palop, OGabau, ECasamitjana, LDeus, JNovell, RCaixas, APrader Willi syndromeFunctional MRIDisgustHypothalamusObjective: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). Methods: Twenty-one genetically-confirmed PWS patients, 30 age-and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings. Results: At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typically related to visually-evoked disgust, such as the anterior insula/frontal operculum, the lateral frontal cortex and visual areas. By contrast, activation was almost absent in limbic structures directly concerned with the regulation of instinctive behavior robustly activated in control subjects, such as the hypothalamus, amygdala/hippocampus and periaqueductal gray. Conclusions: Our study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control.ELSEVIER SCI LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/3090NeuroImage-ClinicalISSN: 22131582reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p30902026-06-21T15:30:37Z
dc.title.none.fl_str_mv Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
spellingShingle Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
Blanco-Hinojo, L
Prader Willi syndrome
Functional MRI
Disgust
Hypothalamus
title_short Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_full Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_fullStr Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_full_unstemmed Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_sort Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
dc.creator.none.fl_str_mv Blanco-Hinojo, L
Pujol, J
Esteba-Castillo, S
Martinez-Vilavella, G
Gimenez-Palop, O
Gabau, E
Casamitjana, L
Deus, J
Novell, R
Caixas, A
author Blanco-Hinojo, L
author_facet Blanco-Hinojo, L
Pujol, J
Esteba-Castillo, S
Martinez-Vilavella, G
Gimenez-Palop, O
Gabau, E
Casamitjana, L
Deus, J
Novell, R
Caixas, A
author_role author
author2 Pujol, J
Esteba-Castillo, S
Martinez-Vilavella, G
Gimenez-Palop, O
Gabau, E
Casamitjana, L
Deus, J
Novell, R
Caixas, A
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prader Willi syndrome
Functional MRI
Disgust
Hypothalamus
topic Prader Willi syndrome
Functional MRI
Disgust
Hypothalamus
description Objective: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). Methods: Twenty-one genetically-confirmed PWS patients, 30 age-and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings. Results: At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typically related to visually-evoked disgust, such as the anterior insula/frontal operculum, the lateral frontal cortex and visual areas. By contrast, activation was almost absent in limbic structures directly concerned with the regulation of instinctive behavior robustly activated in control subjects, such as the hypothalamus, amygdala/hippocampus and periaqueductal gray. Conclusions: Our study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/3090
url https://i3pt.portalinvestigacion.com/publicaciones/3090
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv NeuroImage-Clinical
ISSN: 22131582
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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