Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study

Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascula...

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Autores: Barrubes, Laura, Babio, Nancy, Hernandez-Alonso, Pablo, Toledo, Estefanía, Ramirez Sabio, Judith B, Estruch, Ramon, Ros, Emilio, Fito, Montserrat, Alonso-Gomez, Angel M, Fiol Sala, Miquel, Lapetra, Jose, Serra-Majem, Lluis, Pinto, Xavier, Ruiz-Canela, Miguel, Corella, Dolores, Castaner, Olga, Macias-Gonzalez, Manuel, Salas-Salvado, Jordi
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/22957
Acceso en línea:https://hdl.handle.net/20.500.12105/22957
Access Level:acceso abierto
Palabra clave:WCRF
AICR score
Low-risk lifestyle index
Colorectal cancer
PREDIMED
Lifestyle patterns
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spelling Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed StudyBarrubes, LauraBabio, NancyHernandez-Alonso, PabloToledo, EstefaníaRamirez Sabio, Judith BEstruch, RamonRos, EmilioFito, MontserratAlonso-Gomez, Angel MFiol Sala, MiquelLapetra, JoseSerra-Majem, LluisPinto, XavierRuiz-Canela, MiguelCorella, DoloresCastaner, OlgaMacias-Gonzalez, ManuelSalas-Salvado, JordiWCRFAICR scoreLow-risk lifestyle indexColorectal cancerPREDIMEDLifestyle patternsLimited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.Multidisciplinary Digital Publishing Institute (MDPI)20242024-09-1320202020-04-0120202020-04-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/22957reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/229572026-06-12T12:43:37Z
dc.title.none.fl_str_mv Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
title Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
spellingShingle Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
Barrubes, Laura
WCRF
AICR score
Low-risk lifestyle index
Colorectal cancer
PREDIMED
Lifestyle patterns
title_short Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
title_full Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
title_fullStr Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
title_full_unstemmed Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
title_sort Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
dc.creator.none.fl_str_mv Barrubes, Laura
Babio, Nancy
Hernandez-Alonso, Pablo
Toledo, Estefanía
Ramirez Sabio, Judith B
Estruch, Ramon
Ros, Emilio
Fito, Montserrat
Alonso-Gomez, Angel M
Fiol Sala, Miquel
Lapetra, Jose
Serra-Majem, Lluis
Pinto, Xavier
Ruiz-Canela, Miguel
Corella, Dolores
Castaner, Olga
Macias-Gonzalez, Manuel
Salas-Salvado, Jordi
author Barrubes, Laura
author_facet Barrubes, Laura
Babio, Nancy
Hernandez-Alonso, Pablo
Toledo, Estefanía
Ramirez Sabio, Judith B
Estruch, Ramon
Ros, Emilio
Fito, Montserrat
Alonso-Gomez, Angel M
Fiol Sala, Miquel
Lapetra, Jose
Serra-Majem, Lluis
Pinto, Xavier
Ruiz-Canela, Miguel
Corella, Dolores
Castaner, Olga
Macias-Gonzalez, Manuel
Salas-Salvado, Jordi
author_role author
author2 Babio, Nancy
Hernandez-Alonso, Pablo
Toledo, Estefanía
Ramirez Sabio, Judith B
Estruch, Ramon
Ros, Emilio
Fito, Montserrat
Alonso-Gomez, Angel M
Fiol Sala, Miquel
Lapetra, Jose
Serra-Majem, Lluis
Pinto, Xavier
Ruiz-Canela, Miguel
Corella, Dolores
Castaner, Olga
Macias-Gonzalez, Manuel
Salas-Salvado, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv WCRF
AICR score
Low-risk lifestyle index
Colorectal cancer
PREDIMED
Lifestyle patterns
topic WCRF
AICR score
Low-risk lifestyle index
Colorectal cancer
PREDIMED
Lifestyle patterns
description Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-01
2020
2020-04-01
2024
2024-09-13
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/22957
url https://hdl.handle.net/20.500.12105/22957
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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