Triplet excited states as chiral reporter for the binding of drugs to transport proteins

[EN] The triplet excited state of flurbiprofen methyl ester (FBPMe) has been used as a chiral reporter for the two binding sites of human serum albumin (HSA). The occupation level of the binding sites has been estimated from regression analysis of the triplet decays at several [FBPMe]/[HSA] ratios....

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Detalles Bibliográficos
Autores: Jiménez, M Consuelo|||0000-0002-8057-4316, Vayá Pérez, Ignacio|||0000-0003-1682-9342, Miranda Alonso, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2005
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/150315
Acceso en línea:https://riunet.upv.es/handle/10251/150315
Access Level:acceso abierto
Palabra clave:QUIMICA ORGANICA
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spelling Triplet excited states as chiral reporter for the binding of drugs to transport proteinsJiménez, M Consuelo|||0000-0002-8057-4316Vayá Pérez, Ignacio|||0000-0003-1682-9342Miranda Alonso, Miguel ÁngelQUIMICA ORGANICA[EN] The triplet excited state of flurbiprofen methyl ester (FBPMe) has been used as a chiral reporter for the two binding sites of human serum albumin (HSA). The occupation level of the binding sites has been estimated from regression analysis of the triplet decays at several [FBPMe]/[HSA] ratios. The data agree with two high affinity binding sites (I and II) that are populated to a different extent. A remarkable stereodifferentiation has been found in the drug triplet lifetimes within the protein microenvironment.The UPV (Grant PI 2003-0522 and fellowship to I.V.), the MEC (Grant CTQ2004-03811), and Generalitat Valenciana (Grant GV2004-0536 and Grupos03/082) are gratefully acknowledged for financial support.American Chemical SocietyInstituto Universitario Mixto de Tecnología QuímicaDepartamento de QuímicaEscuela Técnica Superior de Ingeniería IndustrialGrupo de estudio de estados excitados: detección, dinámica, transformaciones y campos de aplicaciónGeneralitat ValencianaUniversitat Politècnica de ValènciaMinisterio de Educación y CienciaRepositorio Institucional de la Universitat Politècnica de València Riunet20052005-07-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/150315reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengGeneralitat Valenciana https://doi.org/10.13039/501100003359 GV2004-0536Universitat Politècnica de València https://doi.org/10.13039/501100004233 PI 2003-0522Generalitat Valenciana https://doi.org/10.13039/501100003359 GRUPOS03%2F082Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 CTQ2004-03811 INTERACCIONES FARMACO-BIOMOLECULA EN LOS ESTADOS EXCITADOSopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1503152026-06-13T07:49:27Z
dc.title.none.fl_str_mv Triplet excited states as chiral reporter for the binding of drugs to transport proteins
title Triplet excited states as chiral reporter for the binding of drugs to transport proteins
spellingShingle Triplet excited states as chiral reporter for the binding of drugs to transport proteins
Jiménez, M Consuelo|||0000-0002-8057-4316
QUIMICA ORGANICA
title_short Triplet excited states as chiral reporter for the binding of drugs to transport proteins
title_full Triplet excited states as chiral reporter for the binding of drugs to transport proteins
title_fullStr Triplet excited states as chiral reporter for the binding of drugs to transport proteins
title_full_unstemmed Triplet excited states as chiral reporter for the binding of drugs to transport proteins
title_sort Triplet excited states as chiral reporter for the binding of drugs to transport proteins
dc.creator.none.fl_str_mv Jiménez, M Consuelo|||0000-0002-8057-4316
Vayá Pérez, Ignacio|||0000-0003-1682-9342
Miranda Alonso, Miguel Ángel
author Jiménez, M Consuelo|||0000-0002-8057-4316
author_facet Jiménez, M Consuelo|||0000-0002-8057-4316
Vayá Pérez, Ignacio|||0000-0003-1682-9342
Miranda Alonso, Miguel Ángel
author_role author
author2 Vayá Pérez, Ignacio|||0000-0003-1682-9342
Miranda Alonso, Miguel Ángel
author2_role author
author
dc.contributor.none.fl_str_mv Instituto Universitario Mixto de Tecnología Química
Departamento de Química
Escuela Técnica Superior de Ingeniería Industrial
Grupo de estudio de estados excitados: detección, dinámica, transformaciones y campos de aplicación
Generalitat Valenciana
Universitat Politècnica de València
Ministerio de Educación y Ciencia
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv QUIMICA ORGANICA
topic QUIMICA ORGANICA
description [EN] The triplet excited state of flurbiprofen methyl ester (FBPMe) has been used as a chiral reporter for the two binding sites of human serum albumin (HSA). The occupation level of the binding sites has been estimated from regression analysis of the triplet decays at several [FBPMe]/[HSA] ratios. The data agree with two high affinity binding sites (I and II) that are populated to a different extent. A remarkable stereodifferentiation has been found in the drug triplet lifetimes within the protein microenvironment.
publishDate 2005
dc.date.none.fl_str_mv 2005
2005-07-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/150315
url https://riunet.upv.es/handle/10251/150315
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Generalitat Valenciana https://doi.org/10.13039/501100003359 GV2004-0536
Universitat Politècnica de València https://doi.org/10.13039/501100004233 PI 2003-0522
Generalitat Valenciana https://doi.org/10.13039/501100003359 GRUPOS03%2F082
Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 CTQ2004-03811 INTERACCIONES FARMACO-BIOMOLECULA EN LOS ESTADOS EXCITADOS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417160619589632
score 15,301603

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