TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate

TNFα exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and...

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Autores: Paniagua Gómez-Álvarez, Ricardo, Royuela García, María del Mar|||0000-0003-1999-9849, Fraile Laiz, Benito|||0000-0002-4847-055X, Rodríguez Berriguete, Gonzalo
Tipo de recurso: artículo
Fecha de publicación:2008
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/32678
Acceso en línea:http://hdl.handle.net/10017/32678
https://dx.doi.org/10.14670/HH-23.1279
Access Level:acceso abierto
Palabra clave:Prostate carcinoma
IL-1
TNF-α
NF-κB
NIK
p38
Antineoplastic Agents/therapeutic use
Apoptosis
Cell Proliferation
Cell Survival
Humans
Interleukin-1/antagonists & inhibitors
Interleukin-1/metabolism
Male
NF-kappa B/metabolism
Prostatic Neoplasms/drug therapy
Prostatic Neoplasms/metabolism
Prostatic Neoplasms/pathology
Protein-Serine-Threonine Kinases/metabolism
Signal Transduction/drug effects
Transcription Factor AP-1/metabolism
Tumor Necrosis Factor-alpha/antagonists & inhibitors
Tumor Necrosis Factor-alpha/metabolism
p38 Mitogen-Activated Protein Kinases/metabolism
Biología
Genética
Ciencia
Biology
Genetics
Science
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network_acronym_str ES
network_name_str España
repository_id_str
spelling TNF-α/IL-1/NF-κB transduction pathway in human cancer prostatePaniagua Gómez-Álvarez, RicardoRoyuela García, María del Mar|||0000-0003-1999-9849Fraile Laiz, Benito|||0000-0002-4847-055XRodríguez Berriguete, GonzaloProstate carcinomaIL-1TNF-αNF-κBNIKp38Antineoplastic Agents/therapeutic useApoptosisCell ProliferationCell SurvivalHumansInterleukin-1/antagonists & inhibitorsInterleukin-1/metabolismMaleNF-kappa B/metabolismProstatic Neoplasms/drug therapyProstatic Neoplasms/metabolismProstatic Neoplasms/pathologyProtein-Serine-Threonine Kinases/metabolismSignal Transduction/drug effectsTranscription Factor AP-1/metabolismTumor Necrosis Factor-alpha/antagonists & inhibitorsTumor Necrosis Factor-alpha/metabolismp38 Mitogen-Activated Protein Kinases/metabolismBiologíaGenéticaCienciaBiologyGeneticsScienceTNFα exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcription factor AP-1. TNFα also exerts proliferation by p38 activation, or when TRAF-2 simultaneously induces the transcription factor NF-κB by NIK. NIK and p38 may also be activated by IL-1. P38 activated several transcription factors such as Elk-1, ATF-2 and NF-κB. NIK also may activate NF-κB. The aim of the present article was to evaluate the different components of this TNFα/IL-1 transduction pathway in human prostate carcinoma (PC) in comparison with normal human prostate. In prostate cancer, pro-apoptotic TNFα/AP-1 pathway is probably inactivated by different factors such as p21 (at ASK-1 level) and bcl-2 (at JNK level), or diverted towards p38 or NIK activation. IL-1α enhances proliferation through IL-1RI that activates either NIK or p38 transduction pathway. P38 and NIK activate different transcription factors related with cell proliferation and survival such as ATF-2, Elk-1 or NF-κB. In order to search a possible target to cancer prostate treatment we proposed that inhibition of several proinflamatory cytokines such as IL-1 and TNFα might be a possible target for PC treatment, because decrease the activity of all transduction pathway members that activate transcription factors as NF-κB, Elk-1 or ATF-2.Ministerio de Educación y CienciaSercrisma International S.L.20082008-04-14journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/32678https://dx.doi.org/10.14670/HH-23.127918712680reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Educación y Ciencia Not available SAF2007-61928 ACTIVACIÓN DE IAPS (PROTEÍNAS INHIBIDORAS DE APOPTOSIS) Y CASPASAS EN CANCÉR DE PRÓSTATA MEDIANTE MAPKS (PROTEÍNAS QUINASAS ACTIVADAS POR MITÓGENOS) Y NF-KB. UTILIDAD PREDICTIVA DE POSIBLES RECIDIVASopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/326782026-06-18T11:13:07Z
dc.title.none.fl_str_mv TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
title TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
spellingShingle TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
Paniagua Gómez-Álvarez, Ricardo
Prostate carcinoma
IL-1
TNF-α
NF-κB
NIK
p38
Antineoplastic Agents/therapeutic use
Apoptosis
Cell Proliferation
Cell Survival
Humans
Interleukin-1/antagonists & inhibitors
Interleukin-1/metabolism
Male
NF-kappa B/metabolism
Prostatic Neoplasms/drug therapy
Prostatic Neoplasms/metabolism
Prostatic Neoplasms/pathology
Protein-Serine-Threonine Kinases/metabolism
Signal Transduction/drug effects
Transcription Factor AP-1/metabolism
Tumor Necrosis Factor-alpha/antagonists & inhibitors
Tumor Necrosis Factor-alpha/metabolism
p38 Mitogen-Activated Protein Kinases/metabolism
Biología
Genética
Ciencia
Biology
Genetics
Science
title_short TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
title_full TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
title_fullStr TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
title_full_unstemmed TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
title_sort TNF-α/IL-1/NF-κB transduction pathway in human cancer prostate
dc.creator.none.fl_str_mv Paniagua Gómez-Álvarez, Ricardo
Royuela García, María del Mar|||0000-0003-1999-9849
Fraile Laiz, Benito|||0000-0002-4847-055X
Rodríguez Berriguete, Gonzalo
author Paniagua Gómez-Álvarez, Ricardo
author_facet Paniagua Gómez-Álvarez, Ricardo
Royuela García, María del Mar|||0000-0003-1999-9849
Fraile Laiz, Benito|||0000-0002-4847-055X
Rodríguez Berriguete, Gonzalo
author_role author
author2 Royuela García, María del Mar|||0000-0003-1999-9849
Fraile Laiz, Benito|||0000-0002-4847-055X
Rodríguez Berriguete, Gonzalo
author2_role author
author
author
dc.subject.none.fl_str_mv Prostate carcinoma
IL-1
TNF-α
NF-κB
NIK
p38
Antineoplastic Agents/therapeutic use
Apoptosis
Cell Proliferation
Cell Survival
Humans
Interleukin-1/antagonists & inhibitors
Interleukin-1/metabolism
Male
NF-kappa B/metabolism
Prostatic Neoplasms/drug therapy
Prostatic Neoplasms/metabolism
Prostatic Neoplasms/pathology
Protein-Serine-Threonine Kinases/metabolism
Signal Transduction/drug effects
Transcription Factor AP-1/metabolism
Tumor Necrosis Factor-alpha/antagonists & inhibitors
Tumor Necrosis Factor-alpha/metabolism
p38 Mitogen-Activated Protein Kinases/metabolism
Biología
Genética
Ciencia
Biology
Genetics
Science
topic Prostate carcinoma
IL-1
TNF-α
NF-κB
NIK
p38
Antineoplastic Agents/therapeutic use
Apoptosis
Cell Proliferation
Cell Survival
Humans
Interleukin-1/antagonists & inhibitors
Interleukin-1/metabolism
Male
NF-kappa B/metabolism
Prostatic Neoplasms/drug therapy
Prostatic Neoplasms/metabolism
Prostatic Neoplasms/pathology
Protein-Serine-Threonine Kinases/metabolism
Signal Transduction/drug effects
Transcription Factor AP-1/metabolism
Tumor Necrosis Factor-alpha/antagonists & inhibitors
Tumor Necrosis Factor-alpha/metabolism
p38 Mitogen-Activated Protein Kinases/metabolism
Biología
Genética
Ciencia
Biology
Genetics
Science
description TNFα exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcription factor AP-1. TNFα also exerts proliferation by p38 activation, or when TRAF-2 simultaneously induces the transcription factor NF-κB by NIK. NIK and p38 may also be activated by IL-1. P38 activated several transcription factors such as Elk-1, ATF-2 and NF-κB. NIK also may activate NF-κB. The aim of the present article was to evaluate the different components of this TNFα/IL-1 transduction pathway in human prostate carcinoma (PC) in comparison with normal human prostate. In prostate cancer, pro-apoptotic TNFα/AP-1 pathway is probably inactivated by different factors such as p21 (at ASK-1 level) and bcl-2 (at JNK level), or diverted towards p38 or NIK activation. IL-1α enhances proliferation through IL-1RI that activates either NIK or p38 transduction pathway. P38 and NIK activate different transcription factors related with cell proliferation and survival such as ATF-2, Elk-1 or NF-κB. In order to search a possible target to cancer prostate treatment we proposed that inhibition of several proinflamatory cytokines such as IL-1 and TNFα might be a possible target for PC treatment, because decrease the activity of all transduction pathway members that activate transcription factors as NF-κB, Elk-1 or ATF-2.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-04-14
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/32678
https://dx.doi.org/10.14670/HH-23.1279
18712680
url http://hdl.handle.net/10017/32678
https://dx.doi.org/10.14670/HH-23.1279
identifier_str_mv 18712680
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Educación y Ciencia Not available SAF2007-61928 ACTIVACIÓN DE IAPS (PROTEÍNAS INHIBIDORAS DE APOPTOSIS) Y CASPASAS EN CANCÉR DE PRÓSTATA MEDIANTE MAPKS (PROTEÍNAS QUINASAS ACTIVADAS POR MITÓGENOS) Y NF-KB. UTILIDAD PREDICTIVA DE POSIBLES RECIDIVAS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sercrisma International S.L.
publisher.none.fl_str_mv Sercrisma International S.L.
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417134022459392
score 15,301603

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