Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding

Introduction: The aims of the present study are to assess the temporal trends of organochlorine compounds (OCs) concentrations and total serum burdens from birth until adolescence and the influence of breastfeeding in these temporal trends. Methods: In 1997 two birth cohort studies were set up in Ri...

Descripción completa

Detalles Bibliográficos
Autores: Gascon, Mireia, Vrijheid, Martine, Garí, Mercè, Fort, Marta, Grimalt, Joan O., Martínez, David Parés, Torrent, Maties, Guxens, M., Sunyer, J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/135175
Acceso en línea:http://hdl.handle.net/10261/135175
Access Level:acceso abierto
Palabra clave:Children
Dichlorodiphenyldichloroethylene
Hexachlorobenzene
Hexachlorohexane
Organochlorine compounds
Polychlorobiphenyls
id ES_b3263aca8a5fbde8a00635d0d69ad656
oai_identifier_str oai:digital.csic.es:10261/135175
network_acronym_str ES
network_name_str España
repository_id_str
spelling Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeedingGascon, MireiaVrijheid, MartineGarí, MercèFort, MartaGrimalt, Joan O.Martínez, David ParésTorrent, MatiesGuxens, M.Sunyer, J.ChildrenDichlorodiphenyldichloroethyleneHexachlorobenzeneHexachlorohexaneOrganochlorine compoundsPolychlorobiphenylsIntroduction: The aims of the present study are to assess the temporal trends of organochlorine compounds (OCs) concentrations and total serum burdens from birth until adolescence and the influence of breastfeeding in these temporal trends. Methods: In 1997 two birth cohort studies were set up in Ribera d'Ebre (N=102) and the island of Menorca (N=482), Spain. Concentrations (ng/mL) of OCs [pentachlorobenzene (PeCB), four isomers of hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (4,4'-DDT), dichlorodiphenyldichloroethylene (4,4'-DDE) and seven polychlorobiphenyl congeners (σ7PCBs)] were measured in cord blood and at the age of 4 and 14years. The total serum burdens (ng) of these compounds were estimated based on the total blood volume (mL) of children at the different ages. We compared median concentrations and total serum burdens of these OCs at the different time-points of follow-up between children of Ribera d'Ebre and Menorca and between breastfed and non-breastfed children. Results: From birth until adolescence concentrations of all OCs drastically reduced. These reductions were mainly derived from the dilution of OCs, associated to an increase in total blood volume of children at the age of 4 and 14years. Despite the reduction in OCs concentrations, the total serum burdens of 4,4'-DDE and σ7PCBs, were higher in adolescents than at birth. Increases in OCs total serum burden occurred both in breastfed and non-breastfed children, but were significantly higher in the first. Conclusions: Even after decades of banning OCs production and use, current young generations in westernized countries are still bioaccumulating these compounds. Given the potential health effects of OCs, especial attention should be paid in the control of secondary emissions in the environment and in the control of food production and contamination. In countries with endemic malaria it is important to work towards effective alternatives to the use of DDT. © 2014 Elsevier Ltd.This study was supported by grants from the Spanish Ministry of Health (FIS-97/1102, FIS 97/0588, 00/0021-2, PI061756, PS0901958 and FIS PS09/00362), the Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), Fundació La Caixa (97/009-00 and 00/077-00), and the Generalitat de Catalunya-CIRIT 1999SGR 00241. Finally, the authors would like to be grateful to the families in Flix and Menorca participating in the study, to the high school management team of Flix for their interest and collaboration, and to Rosa Maria Sabaté, the nurse of the health center of Flix, for her support and commitment.Peer reviewedElsevierConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/135175reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.envint.2014.10.010Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1351752026-05-22T06:33:51Z
dc.title.none.fl_str_mv Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
title Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
spellingShingle Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
Gascon, Mireia
Children
Dichlorodiphenyldichloroethylene
Hexachlorobenzene
Hexachlorohexane
Organochlorine compounds
Polychlorobiphenyls
title_short Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
title_full Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
title_fullStr Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
title_full_unstemmed Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
title_sort Temporal trends in concentrations and total serum burdens of organochlorine compounds from birth until adolescence and the role of breastfeeding
dc.creator.none.fl_str_mv Gascon, Mireia
Vrijheid, Martine
Garí, Mercè
Fort, Marta
Grimalt, Joan O.
Martínez, David Parés
Torrent, Maties
Guxens, M.
Sunyer, J.
author Gascon, Mireia
author_facet Gascon, Mireia
Vrijheid, Martine
Garí, Mercè
Fort, Marta
Grimalt, Joan O.
Martínez, David Parés
Torrent, Maties
Guxens, M.
Sunyer, J.
author_role author
author2 Vrijheid, Martine
Garí, Mercè
Fort, Marta
Grimalt, Joan O.
Martínez, David Parés
Torrent, Maties
Guxens, M.
Sunyer, J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Children
Dichlorodiphenyldichloroethylene
Hexachlorobenzene
Hexachlorohexane
Organochlorine compounds
Polychlorobiphenyls
topic Children
Dichlorodiphenyldichloroethylene
Hexachlorobenzene
Hexachlorohexane
Organochlorine compounds
Polychlorobiphenyls
description Introduction: The aims of the present study are to assess the temporal trends of organochlorine compounds (OCs) concentrations and total serum burdens from birth until adolescence and the influence of breastfeeding in these temporal trends. Methods: In 1997 two birth cohort studies were set up in Ribera d'Ebre (N=102) and the island of Menorca (N=482), Spain. Concentrations (ng/mL) of OCs [pentachlorobenzene (PeCB), four isomers of hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (4,4'-DDT), dichlorodiphenyldichloroethylene (4,4'-DDE) and seven polychlorobiphenyl congeners (σ7PCBs)] were measured in cord blood and at the age of 4 and 14years. The total serum burdens (ng) of these compounds were estimated based on the total blood volume (mL) of children at the different ages. We compared median concentrations and total serum burdens of these OCs at the different time-points of follow-up between children of Ribera d'Ebre and Menorca and between breastfed and non-breastfed children. Results: From birth until adolescence concentrations of all OCs drastically reduced. These reductions were mainly derived from the dilution of OCs, associated to an increase in total blood volume of children at the age of 4 and 14years. Despite the reduction in OCs concentrations, the total serum burdens of 4,4'-DDE and σ7PCBs, were higher in adolescents than at birth. Increases in OCs total serum burden occurred both in breastfed and non-breastfed children, but were significantly higher in the first. Conclusions: Even after decades of banning OCs production and use, current young generations in westernized countries are still bioaccumulating these compounds. Given the potential health effects of OCs, especial attention should be paid in the control of secondary emissions in the environment and in the control of food production and contamination. In countries with endemic malaria it is important to work towards effective alternatives to the use of DDT. © 2014 Elsevier Ltd.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/135175
url http://hdl.handle.net/10261/135175
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.envint.2014.10.010
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417133553745920
score 15.81155

Similares en LA Referencia