Exosome-mimetic nanoplatforms for targeted cancer drug delivery

© The Author(s) 2019.

Bibliographic Details
Authors: Vázquez-Ríos, Abi J., Molina-Crespo, Ángela, Bouzo, Belén L., López-López, Rafael, Moreno-Bueno, Gema, Fuente, María de la
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/206550
Online Access:http://hdl.handle.net/10261/206550
Access Level:Open access
Keyword:Exosomes
Exosome-mimetic nanoplatforms
Biomimetics
Drug delivery systems
Gene therapy
Cancer
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network_acronym_str ES
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spelling Exosome-mimetic nanoplatforms for targeted cancer drug deliveryVázquez-Ríos, Abi J.Molina-Crespo, ÁngelaBouzo, Belén L.López-López, RafaelMoreno-Bueno, GemaFuente, María de laExosomesExosome-mimetic nanoplatformsBiomimeticsDrug delivery systemsGene therapyCancer© The Author(s) 2019.[Background]: Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes have been suggested to be ideal drug delivery systems with application in a broad range of pathologies including cancer, due to their organotropic properties. Tumor-derived exosomes, having tumor-homing properties, can efficiently reach cancer cells and therefore behave as carriers for improved drug delivery to the primary tumor and metastases. However, due to their complex composition, and still undefined biological functions, safety concerns arise hampering their translation to the clinics.[Results]: We propose here the development of exosome-mimetic nanosystems (EMNs) that simulate natural tumor-derived exosomes with respect to their structure and functionality, but with a controlled composition, for the targeted delivery of therapeutic oligonucleotides to lung adenocarcinoma cells (microRNA-145 mimics). Making use of the well-known liposome technology, EMNs can be engineered, loaded with the therapeutic compounds, and tailored with specific proteins (integrin α6β4) providing them organotropic properties. EMNs show great similarities to natural exosomes with respect to their physicochemical properties, drug loading capacity, and ability to interact with the cancer target cells in vitro and in vivo, but are easier to manufacture, can be produced at high yields, and are safer by definition.[Conclusions]: We have designed a multifunctional nanoplatform mimicking exosomes, EMNs, and proved their potential to reach cancer cells with a similar efficient that tumor-derived exosomes but providing important advantages in terms of production methodology and regulations. Additionally, EMNs are highly versatile systems that can be tunable for a broader range of applications.This work was in part supported by grants from Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (FEDER) (CP12/03150, PI15/00828, and CB16/12/00328 from M.F. and PI16/0014, CIBERONC CB16/12/00295 from G.M.B). A.V.R. also acknowledges the fnancial support from the Spanish Ministry of Education, Culture, and Sport (FPU15/06595).BioMed CentralInstituto de Salud Carlos IIIEuropean CommissionMinisterio de Educación, Cultura y Deporte (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/206550reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/s12951-019-0517-8Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2065502026-05-22T06:33:51Z
dc.title.none.fl_str_mv Exosome-mimetic nanoplatforms for targeted cancer drug delivery
title Exosome-mimetic nanoplatforms for targeted cancer drug delivery
spellingShingle Exosome-mimetic nanoplatforms for targeted cancer drug delivery
Vázquez-Ríos, Abi J.
Exosomes
Exosome-mimetic nanoplatforms
Biomimetics
Drug delivery systems
Gene therapy
Cancer
title_short Exosome-mimetic nanoplatforms for targeted cancer drug delivery
title_full Exosome-mimetic nanoplatforms for targeted cancer drug delivery
title_fullStr Exosome-mimetic nanoplatforms for targeted cancer drug delivery
title_full_unstemmed Exosome-mimetic nanoplatforms for targeted cancer drug delivery
title_sort Exosome-mimetic nanoplatforms for targeted cancer drug delivery
dc.creator.none.fl_str_mv Vázquez-Ríos, Abi J.
Molina-Crespo, Ángela
Bouzo, Belén L.
López-López, Rafael
Moreno-Bueno, Gema
Fuente, María de la
author Vázquez-Ríos, Abi J.
author_facet Vázquez-Ríos, Abi J.
Molina-Crespo, Ángela
Bouzo, Belén L.
López-López, Rafael
Moreno-Bueno, Gema
Fuente, María de la
author_role author
author2 Molina-Crespo, Ángela
Bouzo, Belén L.
López-López, Rafael
Moreno-Bueno, Gema
Fuente, María de la
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Ministerio de Educación, Cultura y Deporte (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Exosomes
Exosome-mimetic nanoplatforms
Biomimetics
Drug delivery systems
Gene therapy
Cancer
topic Exosomes
Exosome-mimetic nanoplatforms
Biomimetics
Drug delivery systems
Gene therapy
Cancer
description © The Author(s) 2019.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/206550
url http://hdl.handle.net/10261/206550
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/s12951-019-0517-8
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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