Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017

Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral t...

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Autores: Frank, Tahvi D., Carter, Austin, Jahagirdar, Deepa, Biehl, Molly H., Douwes-Schultz, Dirk, Larson, Samantha Leigh, Arora, Megha, Dwyer-Lindgren, Laura, Steuben, Krista M., Abbastabar, Hedayat, Abu-Raddad, Laith Jamal, Abyu, Direslgne Misker, Adabi, Maryam, Adebayo, Oladimeji M., Adekanmbi, Victor, Adetokunboh, Olatunji O., Ahmadi, Alireza, Ahmadi, Keivan, Ahmadian, Elham, Ahmadpour, Ehsan, Ahmed, Muktar Beshir, Akal, Chalachew Genet, Alahdab, Fares, Alam, Noore, Albertson, Samuel B., Alemnew, Birhan Tamene T., Alene, Kefyalew Addis, Alipour, Vahid, Alvis-Guzman, Nelson, Amini, Saeed, Anbari, Zohreh, Anber, Nahla Hamed, Anjomshoa, Mina, Antonio, Carl Abelardo T., Arabloo, Jalal, Aremu, Olatunde, Areri, Habtamu Abera, Asfaw, Ephrem Tsegay, Ashagre, Alebachew Fasil, Asmelash, Daniel, Asrat, Anemaw A., Avokpaho, Euripide F. G. A., Awasthi, Ashish, Awoke, Nefsu, Ayanore, Martin Amogre, Azari, Samad, Badawi, Alaa, Bagherzadeh, Mojtaba, Banach, Maciej, Barac, Aleksandra, Barnighausen, Till Winfried, Basu, Sanjay, Bedi, Neeraj, Behzadifar, Masoud, Bekele, Bayu Begashaw, Belay, Saba Abraham, Belay, Yared Belete, Belayneh, Yaschilal Muche Muche, Berhane, Adugnaw, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Biadgo, Belete, Bijani, Ali, Bin Sayeed, Muhammad Shahdaat, Bitew, Helen, Blinov, Andrew, Bogale, Kassawmar Angaw, Bojia, Hunduma Amensisa, Nagaraja, Sharath B. N. Burugina, Butt, Zahid A., Cahuana-Hurtado, Lucero, Rincon, Julio Cesar Campuzano, Carvalho, Flix, Chattu, Vijay Kumar, Christopher, Devasahayam J., Chu, Dinh-Toi, Crider, Raquel, Dahiru, Tukur, Dandona, Lalit, Dandona, Rakhi, Daryani, Ahmad, das Neves, Jose, De Neve, Jan-Walter, Degenhardt, Louisa, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh Bizuneh, Demissie, Dereje Bayissa, Demoz, Gebre Teklemariam, Deribe, Kebede, Des Jarlais, Don, Dhungana, Govinda Prasad, Diaz, Daniel, Djalalinia, Shirin, Huyen Phuc Do, Linh Phuong Doan, Duber, Herbert, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Adema, Bereket Duko, Effiong, Andem, Eftekhari, Aziz, Zaki, Maysaa El Sayed, El-Jaafary, I, Shaimaa, El-Khatib, Ziad, Elsharkawy, Aisha, Endries, Aman Yesuf, Eskandarieh, Sharareh, Eyawo, Oghenowede, Farzadfar, Farshad, Fatima, Batool, Fentahun, Netsanet, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Folayan, Morenike Oluwatoyin, Foroutan, Masoud, Fukumoto, Takeshi, Fullman, Nancy, Garcia-Basteiro, Alberto L., Gayesa, Reta Tsegaye, Gebremedhin, Ketema Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebreyohannes, Kelali Kalaye, Gedefaw, Getnet Azeze, Gelaw, Belayneh K., Gesesew, Hailay Abrha, Geta, Birhanu, Gezae, Kebede Embaye, Ghadiri, Keyghobad, Ghashghaee, Ahmad, Ginindza, Themba T. G., Gugnani, Harish Chander, Guimares, Rafael Alves, Haile, Michael Tamene, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamidi, Samer, Handanagic, Senad, Handiso, Demelash Woldeyohannes, Hanfore, Lolemo Kelbiso, Hasanzadeh, Amir, Hassankhani, Hadi, Hassen, Hamid Yimam, Hay, I, Simon, Henok, Andualem, Chi Linh Hoang, Hosgood, H. Dean, Hosseinzadeh, Mehdi, Hsairi, Mohamed, Ibitoye, Segun Emmanuel, Idrisov, Bulat, Ikuta, Kevin S., Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Iwu, Chinwe Juliana, Jacobsen, Kathryn H., James, Spencer L., Jenabi, Ensiyeh, Jha, Ravi Prakash, Jonas, Jost B., Shushtari, Zahra Jorjoran, Kabir, Ali, Kabir, Zubair, Kadel, Rajendra, Kasaeian, Amir, Kassa, Belete, Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kayode, Gbenga A., Kebede, Mihiretu M., Kefale, Adane Teshome, Kengne, Andre Pascal, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalid, Nauman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Junaid, Khang, Young-Ho, Khatab, Khaled, Khazaei, Salman, Khoja, Abdullah T., Kiadaliri, Aliasghar A., Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kochhar, Sonali, Komaki, Hamidreza, Koul, Parvaiz A., Koyanagi, Ai, Defo, Barthelemy Kuate, Kumar, G. Anil, Kumar, Manasi, Kuupiel, Desmond, Lal, Dharmesh Kumar, Lee, Jane Jean-Hee, Lenjebo, Tsegaye Lolaso, Leshargie, Cheru Tesema, Macarayan, Erlyn Rachelle King, Maddison, Emilie R., Abd El Razek, Hassan Magdy, Magis-Rodriguez, Carlos, Mahasha, Phetole Walter, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Manafi, Navid, Mapoma, Chabila Christopher, Martins-Melo, Francisco Rogerlandio, Masaka, Anthony, Mayenga, Emmanuel Ngassa Laurent, Mehta, Varshil, Meles, Gebrekiros Gebremichael, Meles, Hagazi Gebre, Melese, Addisu, Melku, Mulugeta, Memiah, Peter T. N., Memish, Ziad A., Mena, Alemayehu Toma, Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Meretoja, Tuomo J., Mestrovic, Tomislav, Miller, Ted R., Moazen, Babak, Mohajer, Bahram, Mohamadi-Bolbanabad, Amjad, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Darwesh, Aso Mohammad, Mezerji, Naser Mohammad Gholi, Mohammadi, Moslem, Mohammadibakhsh, Roghayeh, Mohammadoo-Khorasani, Milad, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H., Moodley, Yoshan, Moossavi, Maryam, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moschos, Marilita M., Mossie, Tilahun Belete, Mousavi, Seyyed Meysam, Muchie, Kindie Fentahun, Muluneh, Atalay Goshu, Muriithi, Moses K., Mustafa, Ghulam, Muthupandian, Saravanan, Nagarajan, Ahamarshan Jayaraman, Naik, Gurudatta, Najafi, Farid, Nazari, Javad, Ndwandwe, Duduzile Edith, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Son Hoang Nguyen, Trang Huyen Nguyen, Ningrum, Dina Nur Anggraini, Nixon, Molly R., Nnaji, Chukwudi A., Noroozi, Mehdi, Noubiap, Jean Jacques, Shiadeh, Malihe Nourollahpour, Obsa, Mohammed Suleiman, Odame, Emmanuel Ankrah, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew T., Olagunju, Tinuke O., Olum, Solomon, Asante, Kwaku Oppong, Oren, Eyal, Otstavnov, Stanislav S., Mahesh, P. A., Padubidri, Jagadish Rao, Pakhale, Smita, Pakpour, Amir H., Patel, Sangram Kishor, Paulos, Kebreab, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K., Piroozi, Bakhtiar, Pourshams, Akram, Qorbani, Mostafa, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Ranabhat, Chhabi Lal, Rawaf, Salman, Reis, Cesar, Renjith, Vishnu, Reta, Melese Abate, Rezai, Mohammad Sadegh, Rios Gonazlez, Carlos Miguel, Roro, Elias E. M. Merdassa, Rostami, Ali, Rubino, Salvatore, Moghaddam, Sahar Saeedi, Safari, Saeed, Sagar, Rajesh, Sahraian, Mohammad Ali, Salem, Marwa R. Rashad, Salimi, Yahya, Salomon, Joshua A., Sambala, Evanson Zondani, Samy, Abdallah M., Sartorius, Benn, Satpathy, Maheswar, Sawhney, Monika, Sayyah, Mehdi, Schutte, Aletta Elisabeth, Sepanlou, Sadaf G., Seyedmousavi, Seyedmojtaba, Shabaninejad, Hosein, Shaheen, Amira A., Shaikh, Masood Ali, Shallo, Seifadin Ahmed, Shamsizadeh, Morteza, Sharifi, Hamid, Shibuya, Kenji, Shin, Jae Il, Shirkoohi, Reza, Santos Silva, Diego Augusto, Alves Silveira, Dayane Gabriele, Singh, Jasvinder A., Sisay, Malede Mequanent M., Sisay, Mekonnen, Sisay, Solomon, Smith, Amanda E., Sokhan, Anton, Somayaji, Ranjani, Soshnikov, Sergey, Stein, Dan J., Sufiyan, Mu'awiyyah Babale, Sunguya, Bruno F., Sykes, Bryan L., Tadesse, Birkneh Tilahun, Tadesse, Degena Bahrey, Tamirat, Koku Sisay, Taveira, Nuno, Tekelemedhin, Shishay Wahdey, Temesgen, Habtamu Denekew, Tesfay, Fisaha Haile, Teshale, Manaye Yihune, Thapa, Subash, Tlaye, Kenean Getaneh, Topp, Stephanie M., Tovani-Palone, Marcos Roberto, Bach Xuan Tran, Khanh Bao Tran, Ullah, Irfan, Unnikrishnan, Bhaskaran, Uthman, Olalekan A., Veisani, Yousef, Vladimirov, Sergey Konstantinovitch, Wada, Fiseha Wadilo, Waheed, Yasir, Weldegwergs, Kidu Gidey, Weldesamuel, Girmay Teklay T., Westerman, Ronny, Wijeratne, Tissa, Wolde, Haileab Fekadu, Wondafrash, Dawit Zewdu, Wonde, Tewodros Eshete, Wondmagegn, Berhanu Yazew, Yeshanew, Addisu Gize, Yilma, Mekdes Tigistu, Yimer, Ebrahim M., Yonemoto, Naohiro, Yotebieng, Marcel, Youm, Yoosik, Yu, Chuanhua, Zaidi, Zoubida, Zarghi, Afshin, Zenebe, Zerihun Menlkalew, Zewale, Taye Abuhay, Ziapour, Arash, Zodpey, Sanjay, Naghavi, Mohsen, Vollset, Stein Emil, Wang, Haidong, Lim, Stephen S., Kyu, Hmwe Hmwe, L Murray, Christopher J.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Fundació Sant Joan de Déu
Repositório:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p23877
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23877
Access Level:Acceso aberto
Palavra-chave:SEX-SPECIFIC MORTALITY
UNITED-STATES
LIFE EXPECTANCY
PREVENTION
CHALLENGES
DISABILITY
CITIES
TRENDS
MEN
Descrição
Resumo:Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980-2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package-a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce age-sex-specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1.95 million deaths (95% uncertainty interval 1.87-2.04) and has since decreased to 0.95 million deaths (0.91-1.01) in 2017. New cases of HIV globally peaked in 1999 (3.16 million, 2.79-3.67) and since then have gradually decreased to 1.94 million (1.63-2.29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36.8 million (34.8-39.2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65.7% in Lesotho to 85.7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.

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