Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques

Cortical spreading depolarization (CSD) is a pathophysiological event critically implicated in ischemic stroke and other brain disorders. It consists of slowly propagating waves of massive neuronal and glial depolarization in cerebral gray matter, accompanied by spreading depression of cortical acti...

ver descrição completa

Detalhes bibliográficos
Autores: Díaz-Pérez, Andrea, de Eulate, Nerea Alvarez, Masvidal Codina, Eduard, Illa, Xavi, Navarro, Xavier, Guimerà-Brunet, Anton, Jiménez-Altayó, Francesc, Penas, Clara
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420533
Acesso em linha:http://hdl.handle.net/10261/420533
https://api.elsevier.com/content/abstract/scopus_id/105023067299
Access Level:Acceso aberto
Palavra-chave:Brain injury
Cortical spreading depolarization
Electrophysiology
Ischemic stroke
Neuroprotection
Spreading depression
http://metadata.un.org/sdg/9
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
id ES_b2ffa88a36107a7f107bbd72a3ff04d7
oai_identifier_str oai:digital.csic.es:10261/420533
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniquesDíaz-Pérez, Andreade Eulate, Nerea AlvarezMasvidal Codina, EduardIlla, XaviNavarro, XavierGuimerà-Brunet, AntonJiménez-Altayó, FrancescPenas, ClaraBrain injuryCortical spreading depolarizationElectrophysiologyIschemic strokeNeuroprotectionSpreading depressionhttp://metadata.un.org/sdg/9Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovationCortical spreading depolarization (CSD) is a pathophysiological event critically implicated in ischemic stroke and other brain disorders. It consists of slowly propagating waves of massive neuronal and glial depolarization in cerebral gray matter, accompanied by spreading depression of cortical activity. CSD disrupts ion homeostasis, alters cerebral blood flow, and contributes to neuronal death in vulnerable tissue. This comprehensive review summarizes both classic and recent studies on CSD mechanisms and their role in brain damage progression after stroke. We also review potential neuroprotective strategies to mitigate CSD-induced damage and discuss available technologies for detecting CSD. Advancing our understanding of CSD mechanisms, combined with targeted neuroprotective strategies and improved monitoring techniques, holds promise for reducing stroke-related brain injury and guiding personalized recovery approaches.Open Access Funding provided by Universitat Autonoma de Barcelona. This work was supported by grant PID2021-126117NA-I00, CNS2023-144492, PID2022-140655OB-I00, PID2020–113634RB-C22, and PDC2023-145866-I00 funded by MCIU/AEI/https://doi. org/10.13039/501100011033and by the European Union NextGenerationEU/PRTR; by the European Union’s Horizon Europe research and innovation programme under grant agreement 101130650 (META-BRAIN) and 101136541 (GphT-BCI); through the Collaborative CIBERNED-CIBERBBN 2023 project GROKE and CIBERNED (CB06/05/1105) and CIBER-BBN (CB06/01/0049) funds from Instituto de Salud Carlos III of Spain, co-funded by European Union NextGenerationEU/PRTR; and funds from 2021-SGR-00495, 2021-SGR-004488, and 2021-SGR-00969 from Generalitat de Catalunya. The IMB-CNM (CSIC) is supported by the María de Maetzu Centres of Excellence programme ref. CEX2023-001397-M funded by MCINN-AEI.Peer reviewedSpringer NatureEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Generalitat de CatalunyaCentro de Investigación Biomédica en Red (España)0000-0003-0554-3832Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/420533https://api.elsevier.com/content/abstract/scopus_id/105023067299reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126117NA-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-140655OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de InnovaciónPID2020–113634RB-C22/info:eu-repo/grantAgreement/EC/HE/101130650info:eu-repo/grantAgreement/EC/HE/101136541info:eu-repo/grantAgreement/EC/HE/CIBERinfo:eu-repo/grantAgreement/EC/HE/CIBERGeroSciencehttps://doi.org/10.1007/s11357-025-01988-wSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4205332026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
title Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
spellingShingle Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
Díaz-Pérez, Andrea
Brain injury
Cortical spreading depolarization
Electrophysiology
Ischemic stroke
Neuroprotection
Spreading depression
http://metadata.un.org/sdg/9
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
title_short Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
title_full Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
title_fullStr Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
title_full_unstemmed Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
title_sort Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
dc.creator.none.fl_str_mv Díaz-Pérez, Andrea
de Eulate, Nerea Alvarez
Masvidal Codina, Eduard
Illa, Xavi
Navarro, Xavier
Guimerà-Brunet, Anton
Jiménez-Altayó, Francesc
Penas, Clara
author Díaz-Pérez, Andrea
author_facet Díaz-Pérez, Andrea
de Eulate, Nerea Alvarez
Masvidal Codina, Eduard
Illa, Xavi
Navarro, Xavier
Guimerà-Brunet, Anton
Jiménez-Altayó, Francesc
Penas, Clara
author_role author
author2 de Eulate, Nerea Alvarez
Masvidal Codina, Eduard
Illa, Xavi
Navarro, Xavier
Guimerà-Brunet, Anton
Jiménez-Altayó, Francesc
Penas, Clara
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Generalitat de Catalunya
Centro de Investigación Biomédica en Red (España)
0000-0003-0554-3832
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Brain injury
Cortical spreading depolarization
Electrophysiology
Ischemic stroke
Neuroprotection
Spreading depression
http://metadata.un.org/sdg/9
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
topic Brain injury
Cortical spreading depolarization
Electrophysiology
Ischemic stroke
Neuroprotection
Spreading depression
http://metadata.un.org/sdg/9
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
description Cortical spreading depolarization (CSD) is a pathophysiological event critically implicated in ischemic stroke and other brain disorders. It consists of slowly propagating waves of massive neuronal and glial depolarization in cerebral gray matter, accompanied by spreading depression of cortical activity. CSD disrupts ion homeostasis, alters cerebral blood flow, and contributes to neuronal death in vulnerable tissue. This comprehensive review summarizes both classic and recent studies on CSD mechanisms and their role in brain damage progression after stroke. We also review potential neuroprotective strategies to mitigate CSD-induced damage and discuss available technologies for detecting CSD. Advancing our understanding of CSD mechanisms, combined with targeted neuroprotective strategies and improved monitoring techniques, holds promise for reducing stroke-related brain injury and guiding personalized recovery approaches.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/420533
https://api.elsevier.com/content/abstract/scopus_id/105023067299
url http://hdl.handle.net/10261/420533
https://api.elsevier.com/content/abstract/scopus_id/105023067299
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126117NA-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-140655OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de InnovaciónPID2020–113634RB-C22/
info:eu-repo/grantAgreement/EC/HE/101130650
info:eu-repo/grantAgreement/EC/HE/101136541
info:eu-repo/grantAgreement/EC/HE/CIBER
info:eu-repo/grantAgreement/EC/HE/CIBER
GeroScience
https://doi.org/10.1007/s11357-025-01988-w
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417120333299712
score 15,811543

Registros relacionados