Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan

The design and the synthesis of functional films with enhanced functionality represent a significant step forward in sustainable material development due to their potential applications. In this study, a novel chitosan derivative (CS-MeIm) was synthetized by chemically modifying chitosan (CS) struct...

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Detalles Bibliográficos
Autores: Muñoz-Núñez, Carolina, Quiroz Pereira, Yoleida, Muñoz-Bonilla, Alexandra, Fernández-García, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/401672
Acceso en línea:http://hdl.handle.net/10261/401672
Access Level:acceso abierto
Palabra clave:Chitosan
Imidazole
Chitin nanowhiskers
Chemical modification
Antimicrobial
Antioxidant
Films
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spelling Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-ChitosanMuñoz-Núñez, CarolinaQuiroz Pereira, YoleidaMuñoz-Bonilla, AlexandraFernández-García, MartaChitosanImidazoleChitin nanowhiskersChemical modificationAntimicrobialAntioxidantFilmsThe design and the synthesis of functional films with enhanced functionality represent a significant step forward in sustainable material development due to their potential applications. In this study, a novel chitosan derivative (CS-MeIm) was synthetized by chemically modifying chitosan (CS) structure with 1-methyl-1H-imidazole (MeIm), a heterocyclic compound known for its biological properties. This functionalization not only enhances the intrinsic capabilities of CS but also provides a strategic platform for advanced material engineering. The modified compound, CS-MeIm, was incorporated at 10 wt% into films based on CS matrix, which was also reinforced with 1 or 5 wt% of chitin nanowhiskers (ChNw), to improve their functionality for its potential applications. The fabrication process was optimized to ensure the homogeneity and the structural integrity of the films, which were extensively evaluated to study their thermal stability, mechanical integrity, and bioactivity. The incorporation of the imidazole ring into the CS backbone provided a marked enhancement in antioxidant capacity from 3 to 15 μmol Trolox/gram of film; and excellent antimicrobial activity against common microbes, particularly against E. coli with an efficacy of 99.999%. The findings reveal that this chemical modification not only raises the intrinsic properties of CS but also introduces a versatile platform for creating biodegradable films with high functionality.This work was funded by the MICIU (PID2022-13651OB-100), the Agencia Estatal de Investigación (AEI, Spain) and Fondo Europeo de Desarrollo Regional (FEDER, EU). C.M.-N. also acknowledges MICINN for her FPI fellowship PRE2020-093596.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionMuñoz-Núñez, Carolina [0000-0001-9202-3282]Quiroz Pereira, Yoleida [0009-0004-6183-9034]Muñoz-Bonilla, Alexandra [0000-0003-0210-1246]Fernández-García, Marta [0000-0003-2061-0351]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/401672reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//PID2022-13651OB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/polym17192608https://doi.org/10.3390/polym17192608Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4016722026-05-22T06:33:51Z
dc.title.none.fl_str_mv Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
title Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
spellingShingle Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
Muñoz-Núñez, Carolina
Chitosan
Imidazole
Chitin nanowhiskers
Chemical modification
Antimicrobial
Antioxidant
Films
title_short Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
title_full Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
title_fullStr Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
title_full_unstemmed Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
title_sort Enhancing Antimicrobial and Antioxidant Properties of Chitosan-Based Films with 1-Methylimidazolium-Chitosan
dc.creator.none.fl_str_mv Muñoz-Núñez, Carolina
Quiroz Pereira, Yoleida
Muñoz-Bonilla, Alexandra
Fernández-García, Marta
author Muñoz-Núñez, Carolina
author_facet Muñoz-Núñez, Carolina
Quiroz Pereira, Yoleida
Muñoz-Bonilla, Alexandra
Fernández-García, Marta
author_role author
author2 Quiroz Pereira, Yoleida
Muñoz-Bonilla, Alexandra
Fernández-García, Marta
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Muñoz-Núñez, Carolina [0000-0001-9202-3282]
Quiroz Pereira, Yoleida [0009-0004-6183-9034]
Muñoz-Bonilla, Alexandra [0000-0003-0210-1246]
Fernández-García, Marta [0000-0003-2061-0351]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Chitosan
Imidazole
Chitin nanowhiskers
Chemical modification
Antimicrobial
Antioxidant
Films
topic Chitosan
Imidazole
Chitin nanowhiskers
Chemical modification
Antimicrobial
Antioxidant
Films
description The design and the synthesis of functional films with enhanced functionality represent a significant step forward in sustainable material development due to their potential applications. In this study, a novel chitosan derivative (CS-MeIm) was synthetized by chemically modifying chitosan (CS) structure with 1-methyl-1H-imidazole (MeIm), a heterocyclic compound known for its biological properties. This functionalization not only enhances the intrinsic capabilities of CS but also provides a strategic platform for advanced material engineering. The modified compound, CS-MeIm, was incorporated at 10 wt% into films based on CS matrix, which was also reinforced with 1 or 5 wt% of chitin nanowhiskers (ChNw), to improve their functionality for its potential applications. The fabrication process was optimized to ensure the homogeneity and the structural integrity of the films, which were extensively evaluated to study their thermal stability, mechanical integrity, and bioactivity. The incorporation of the imidazole ring into the CS backbone provided a marked enhancement in antioxidant capacity from 3 to 15 μmol Trolox/gram of film; and excellent antimicrobial activity against common microbes, particularly against E. coli with an efficacy of 99.999%. The findings reveal that this chemical modification not only raises the intrinsic properties of CS but also introduces a versatile platform for creating biodegradable films with high functionality.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/401672
url http://hdl.handle.net/10261/401672
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//PID2022-13651OB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/polym17192608
https://doi.org/10.3390/polym17192608
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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