Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved sur...

Descripción completa

Detalles Bibliográficos
Autores: Cabrera-Alarcon, José Luis, Cruz, Raquel, Rosa-Moreno, Marina, Latorre-Pellicer, Ana, de Almeida, Silvia Diz, Riancho, José A, Rojas-Martinez, Augusto, Flores, Carlos, Lapunzina, Pablo, Sánchez-Cabo, Fátima, Carracedo, Ángel, Enriquez, José Antonio, Martínez-López, Icíar, Obrador-Hevia, Antonia
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/26046
Acceso en línea:https://hdl.handle.net/20.500.13003/26046
Access Level:acceso abierto
Palabra clave:COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
ADN Mitocondrial
Estudio de Asociación del Genoma Completo
Haplotipos
Mitocondrias
Índice de Severidad de la Enfermedad
id ES_b2d787c8f0a7593e1c784cf0d7efef4c
oai_identifier_str oai:docusalut.com:20.500.13003/26046
network_acronym_str ES
network_name_str España
repository_id_str
spelling Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severityCabrera-Alarcon, José LuisCruz, RaquelRosa-Moreno, MarinaLatorre-Pellicer, Anade Almeida, Silvia DizRiancho, José ARojas-Martinez, AugustoFlores, CarlosLapunzina, PabloSánchez-Cabo, FátimaCarracedo, ÁngelEnriquez, José AntonioMartínez-López, IcíarObrador-Hevia, AntoniaCOVID-19DNA, MitochondrialGenome-Wide Association StudyHaplotypesMitochondriaSARS-CoV-2Severity of Illness IndexCOVID-19ADN MitocondrialEstudio de Asociación del Genoma CompletoHaplotiposMitocondriasSARS-CoV-2Índice de Severidad de la EnfermedadCOVID-19DNA, MitochondrialGenome-Wide Association StudyHaplotypesMitochondriaSARS-CoV-2Severity of Illness IndexThe frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.Springer Nature20252025-01-0120252025-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/26046reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/260462026-06-22T12:44:07Z
dc.title.none.fl_str_mv Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
spellingShingle Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
Cabrera-Alarcon, José Luis
COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
COVID-19
ADN Mitocondrial
Estudio de Asociación del Genoma Completo
Haplotipos
Mitocondrias
SARS-CoV-2
Índice de Severidad de la Enfermedad
COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
title_short Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_full Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_fullStr Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_full_unstemmed Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_sort Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
dc.creator.none.fl_str_mv Cabrera-Alarcon, José Luis
Cruz, Raquel
Rosa-Moreno, Marina
Latorre-Pellicer, Ana
de Almeida, Silvia Diz
Riancho, José A
Rojas-Martinez, Augusto
Flores, Carlos
Lapunzina, Pablo
Sánchez-Cabo, Fátima
Carracedo, Ángel
Enriquez, José Antonio
Martínez-López, Icíar
Obrador-Hevia, Antonia
author Cabrera-Alarcon, José Luis
author_facet Cabrera-Alarcon, José Luis
Cruz, Raquel
Rosa-Moreno, Marina
Latorre-Pellicer, Ana
de Almeida, Silvia Diz
Riancho, José A
Rojas-Martinez, Augusto
Flores, Carlos
Lapunzina, Pablo
Sánchez-Cabo, Fátima
Carracedo, Ángel
Enriquez, José Antonio
Martínez-López, Icíar
Obrador-Hevia, Antonia
author_role author
author2 Cruz, Raquel
Rosa-Moreno, Marina
Latorre-Pellicer, Ana
de Almeida, Silvia Diz
Riancho, José A
Rojas-Martinez, Augusto
Flores, Carlos
Lapunzina, Pablo
Sánchez-Cabo, Fátima
Carracedo, Ángel
Enriquez, José Antonio
Martínez-López, Icíar
Obrador-Hevia, Antonia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
COVID-19
ADN Mitocondrial
Estudio de Asociación del Genoma Completo
Haplotipos
Mitocondrias
SARS-CoV-2
Índice de Severidad de la Enfermedad
COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
topic COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
COVID-19
ADN Mitocondrial
Estudio de Asociación del Genoma Completo
Haplotipos
Mitocondrias
SARS-CoV-2
Índice de Severidad de la Enfermedad
COVID-19
DNA, Mitochondrial
Genome-Wide Association Study
Haplotypes
Mitochondria
SARS-CoV-2
Severity of Illness Index
description The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/26046
url https://hdl.handle.net/20.500.13003/26046
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417088499580928
score 15,811543

Similares en LA Referencia