An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Li Bassi, Gianluigi; Suen, Jacky Y.; Dalton, Heidi J.; White, Nicole; Shrapnel, Sally; Fanning, Jonathan P.; Liquet, Benoît; Hinton, Samuel; Vuorinen, Aapeli; Booth, Gareth; Millar, Jonathan E.; Forsyth, Simon; Panigada, Mauro; Laffey, John; Brodie, Daniel; Fan, Eddy; Torres Martí, Antoni; Chiumello, Davide; Corley, Amanda; Elhazmi, Alyaa; Hodgson, Carol; Ichiba, Shingo; Luna, Carlos M.; Murthy, Srinivas; Nichol, Alistair; Yeung Ng, Pauline; Ogino, Mark; Pesenti, Antonio; Trieu, Huynh Trung; Fraser, John F.; COVID-19 Critical Care Consortium

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Background: Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous smallcase series or studies conducted at a national level. Methods: We designed a...

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Autores:	Li Bassi, Gianluigi, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Shrapnel, Sally, Fanning, Jonathan P., Liquet, Benoît, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E., Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres Martí, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos M., Murthy, Srinivas, Nichol, Alistair, Yeung Ng, Pauline, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung, Fraser, John F., COVID-19 Critical Care Consortium
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/186681
Acceso en línea:	https://hdl.handle.net/2445/186681
Access Level:	acceso abierto
Palabra clave:	COVID-19 SARS-CoV-2 Respiració artificial Complicacions (Medicina) Unitats de cures intensives Assaigs clínics Artificial respiration Complications (Medicine) Intensive care units Clinical trials

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spelling	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patientsLi Bassi, GianluigiSuen, Jacky Y.Dalton, Heidi J.White, NicoleShrapnel, SallyFanning, Jonathan P.Liquet, BenoîtHinton, SamuelVuorinen, AapeliBooth, GarethMillar, Jonathan E.Forsyth, SimonPanigada, MauroLaffey, JohnBrodie, DanielFan, EddyTorres Martí, AntoniChiumello, DavideCorley, AmandaElhazmi, AlyaaHodgson, CarolIchiba, ShingoLuna, Carlos M.Murthy, SrinivasNichol, AlistairYeung Ng, PaulineOgino, MarkPesenti, AntonioTrieu, Huynh TrungFraser, John F.COVID-19 Critical Care ConsortiumCOVID-19SARS-CoV-2Respiració artificialComplicacions (Medicina)Unitats de cures intensivesAssaigs clínicsCOVID-19SARS-CoV-2Artificial respirationComplications (Medicine)Intensive care unitsClinical trialsBackground: Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous smallcase series or studies conducted at a national level. Methods: We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe CRS calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)] and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. Results: We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of CRS within the frst seven days of MV. Median (IQR) age was 62 (52-71), patients were predominantly males (68%) and from Europe/North and South America (88%). CRS, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p=0.417) nor with PaO2/FiO2 (p=0.100). Females presented lower CRS than males (95% CI of CRS diference between females-males: −11.8 to −7.4 mL/cmH2O p<0.001), and although females presented higher body mass index (BMI), association of BMI with CRS was marginal (p=0.139). Ventilatory management varied across CRS range, resulting in a signifcant association between CRS and driving pressure (estimated decrease −0.31 cmH2O/L per mL/cmH20 of CRS, 95% CI −0.48 to −0.14, p<0.001). Overall, 28-day ICU mortality, accounting for the competing risk of being discharged within the period, was 35.6% (SE 1.7). Cox proportional hazard analysis demonstrated that CRS (+10 mL/cm H2O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02-1.28, p=0.018).BioMed Central2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22 p.application/pdfhttps://hdl.handle.net/2445/186681Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13054-021-03518-4Critical Care, 2021, vol. 25, num. 1, p. 199https://doi.org/10.1186/s13054-021-03518-4info:eu-repo/grantAgreement/EC/H2020/764840cc-by (c) Li Bassi, Gianluigi et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1866812026-05-29T05:05:01Z
dc.title.none.fl_str_mv	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
title	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
spellingShingle	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients Li Bassi, Gianluigi COVID-19 SARS-CoV-2 Respiració artificial Complicacions (Medicina) Unitats de cures intensives Assaigs clínics COVID-19 SARS-CoV-2 Artificial respiration Complications (Medicine) Intensive care units Clinical trials
title_short	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
title_full	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
title_fullStr	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
title_full_unstemmed	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
title_sort	An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
dc.creator.none.fl_str_mv	Li Bassi, Gianluigi Suen, Jacky Y. Dalton, Heidi J. White, Nicole Shrapnel, Sally Fanning, Jonathan P. Liquet, Benoît Hinton, Samuel Vuorinen, Aapeli Booth, Gareth Millar, Jonathan E. Forsyth, Simon Panigada, Mauro Laffey, John Brodie, Daniel Fan, Eddy Torres Martí, Antoni Chiumello, Davide Corley, Amanda Elhazmi, Alyaa Hodgson, Carol Ichiba, Shingo Luna, Carlos M. Murthy, Srinivas Nichol, Alistair Yeung Ng, Pauline Ogino, Mark Pesenti, Antonio Trieu, Huynh Trung Fraser, John F. COVID-19 Critical Care Consortium
author	Li Bassi, Gianluigi
author_facet	Li Bassi, Gianluigi Suen, Jacky Y. Dalton, Heidi J. White, Nicole Shrapnel, Sally Fanning, Jonathan P. Liquet, Benoît Hinton, Samuel Vuorinen, Aapeli Booth, Gareth Millar, Jonathan E. Forsyth, Simon Panigada, Mauro Laffey, John Brodie, Daniel Fan, Eddy Torres Martí, Antoni Chiumello, Davide Corley, Amanda Elhazmi, Alyaa Hodgson, Carol Ichiba, Shingo Luna, Carlos M. Murthy, Srinivas Nichol, Alistair Yeung Ng, Pauline Ogino, Mark Pesenti, Antonio Trieu, Huynh Trung Fraser, John F. COVID-19 Critical Care Consortium
author_role	author
author2	Suen, Jacky Y. Dalton, Heidi J. White, Nicole Shrapnel, Sally Fanning, Jonathan P. Liquet, Benoît Hinton, Samuel Vuorinen, Aapeli Booth, Gareth Millar, Jonathan E. Forsyth, Simon Panigada, Mauro Laffey, John Brodie, Daniel Fan, Eddy Torres Martí, Antoni Chiumello, Davide Corley, Amanda Elhazmi, Alyaa Hodgson, Carol Ichiba, Shingo Luna, Carlos M. Murthy, Srinivas Nichol, Alistair Yeung Ng, Pauline Ogino, Mark Pesenti, Antonio Trieu, Huynh Trung Fraser, John F. COVID-19 Critical Care Consortium
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	COVID-19 SARS-CoV-2 Respiració artificial Complicacions (Medicina) Unitats de cures intensives Assaigs clínics COVID-19 SARS-CoV-2 Artificial respiration Complications (Medicine) Intensive care units Clinical trials
topic	COVID-19 SARS-CoV-2 Respiració artificial Complicacions (Medicina) Unitats de cures intensives Assaigs clínics COVID-19 SARS-CoV-2 Artificial respiration Complications (Medicine) Intensive care units Clinical trials
description	Background: Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous smallcase series or studies conducted at a national level. Methods: We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe CRS calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)] and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. Results: We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of CRS within the frst seven days of MV. Median (IQR) age was 62 (52-71), patients were predominantly males (68%) and from Europe/North and South America (88%). CRS, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p=0.417) nor with PaO2/FiO2 (p=0.100). Females presented lower CRS than males (95% CI of CRS diference between females-males: −11.8 to −7.4 mL/cmH2O p<0.001), and although females presented higher body mass index (BMI), association of BMI with CRS was marginal (p=0.139). Ventilatory management varied across CRS range, resulting in a signifcant association between CRS and driving pressure (estimated decrease −0.31 cmH2O/L per mL/cmH20 of CRS, 95% CI −0.48 to −0.14, p<0.001). Overall, 28-day ICU mortality, accounting for the competing risk of being discharged within the period, was 35.6% (SE 1.7). Cox proportional hazard analysis demonstrated that CRS (+10 mL/cm H2O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02-1.28, p=0.018).
publishDate	2021
dc.date.none.fl_str_mv	2021 2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/186681
url	https://hdl.handle.net/2445/186681
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03518-4 Critical Care, 2021, vol. 25, num. 1, p. 199 https://doi.org/10.1186/s13054-021-03518-4 info:eu-repo/grantAgreement/EC/H2020/764840
dc.rights.none.fl_str_mv	cc-by (c) Li Bassi, Gianluigi et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Li Bassi, Gianluigi et al., 2021 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	22 p. application/pdf
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

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