Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin...

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Detalles Bibliográficos
Autores: González Izquierdo, Andrea, Crujeiras Martínez, Ana Belén, CASANUEVA FREIJO, FELIPE, CARREIRA DELGADO, MANUEL CARLOS
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/15482
Acceso en línea:https://www.ncbi.nlm.nih.gov/pubmed/31717265
http://hdl.handle.net/20.500.11940/15482
Access Level:acceso abierto
Palabra clave:CHUS
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spelling Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?González Izquierdo, AndreaCrujeiras Martínez, Ana BelénCASANUEVA FREIJO, FELIPECARREIRA DELGADO, MANUEL CARLOSCHUSIDISLeptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin. The inability of leptin to exert its anorexigenic effects in obese individuals, and therefore, the lack of clinical utility of leptin in obesity, is defined as leptin resistance. This phenomenon has not yet been adequately characterized. Elucidation of the molecular mechanisms underlying leptin resistance is of vital importance for the application of leptin as an effective treatment for obesity. Leptin must cross the blood-brain barrier (BBB) to reach the hypothalamus and exert its anorexigenic functions. The mechanisms involved in leptin transportation across the blood-brain barrier continue to be unclear, thereby preventing the clinical application of leptin in the treatment of obesity. In recent years, new strategies have been developed to recover the response to leptin in obesity. We have summarized these strategies in this review.2019info:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pubmed/31717265http://hdl.handle.net/20.500.11940/15482reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/154822026-06-12T08:40:47Z
dc.title.none.fl_str_mv Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
title Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
spellingShingle Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
González Izquierdo, Andrea
CHUS
IDIS
title_short Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
title_full Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
title_fullStr Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
title_full_unstemmed Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
title_sort Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
dc.creator.none.fl_str_mv González Izquierdo, Andrea
Crujeiras Martínez, Ana Belén
CASANUEVA FREIJO, FELIPE
CARREIRA DELGADO, MANUEL CARLOS
author González Izquierdo, Andrea
author_facet González Izquierdo, Andrea
Crujeiras Martínez, Ana Belén
CASANUEVA FREIJO, FELIPE
CARREIRA DELGADO, MANUEL CARLOS
author_role author
author2 Crujeiras Martínez, Ana Belén
CASANUEVA FREIJO, FELIPE
CARREIRA DELGADO, MANUEL CARLOS
author2_role author
author
author
dc.subject.none.fl_str_mv CHUS
IDIS
topic CHUS
IDIS
description Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin. The inability of leptin to exert its anorexigenic effects in obese individuals, and therefore, the lack of clinical utility of leptin in obesity, is defined as leptin resistance. This phenomenon has not yet been adequately characterized. Elucidation of the molecular mechanisms underlying leptin resistance is of vital importance for the application of leptin as an effective treatment for obesity. Leptin must cross the blood-brain barrier (BBB) to reach the hypothalamus and exert its anorexigenic functions. The mechanisms involved in leptin transportation across the blood-brain barrier continue to be unclear, thereby preventing the clinical application of leptin in the treatment of obesity. In recent years, new strategies have been developed to recover the response to leptin in obesity. We have summarized these strategies in this review.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.ncbi.nlm.nih.gov/pubmed/31717265
http://hdl.handle.net/20.500.11940/15482
url https://www.ncbi.nlm.nih.gov/pubmed/31717265
http://hdl.handle.net/20.500.11940/15482
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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