Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario
Background. Positron emission tomography with fluor- 18-deoxyglucose (PET-FDG) is an efficient technique for the detection of tumoural tissue. The aim of the paper is to evaluate the PET-FDG in the diagnosis of residual disease or relapse in patients with cancer of the ovary. Methods. A total of 24...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2002 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | español |
| OAI Identifier: | oai:dadun.unav.edu:10171/22582 |
| Acceso en línea: | https://hdl.handle.net/10171/22582 |
| Access Level: | acceso abierto |
| Palabra clave: | Fluorodeoxyglucose Positron emission tomography Cancer of the ovary |
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Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovarioClinical value of positron emission tomography with F-18-FDG in the follow up of patients with cancer of the ovaryGarcia-Velloso, M. J. (María José)|||/items/95484946-2b37-4f2a-943f-fc76c5b2aa8bLopez-Garcia, G. (Guillermo)|||/items/3d04f46d-26ab-4df5-a248-9c2848336522Galan, M.J. (M. J.)|||/items/42c4cf76-d4cf-4d0e-aff8-fb582447f741Meiriño-Seoane, R.M. (Rosa María)|||/items/36afeff9-1fe2-4b0c-8711-b546e32e477eMarti-Climent, J.M. (Josep María)|||/items/dfc511a4-aa92-44b5-8624-17b03d0f3466Boan, J. (J.)|||/items/7a61ba1b-31f3-45c1-b8a8-8697bccf2482Richter, J.A. (José Ángel)|||/items/4b21b403-ba6f-4220-8493-3453c8f876c3FluorodeoxyglucosePositron emission tomographyCancer of the ovaryBackground. Positron emission tomography with fluor- 18-deoxyglucose (PET-FDG) is an efficient technique for the detection of tumoural tissue. The aim of the paper is to evaluate the PET-FDG in the diagnosis of residual disease or relapse in patients with cancer of the ovary. Methods. A total of 24 patients, diagnosed and treated for cancer of the ovary with surgery and subsequent chemotherapy, were included. With 12 patients the study was carried out prior to second-look surgery, and with the other 12 after objectivising an increase of the tumoural marker in the follow up. Abdominal-pelvic CAT, determination of the seric levels of CA-125 and PET-FDG of thorax, abdomen and pelvis were carried out on all patients. The PET-FDG was evaluated in a qualitative way through the visual study of the images, and quantitatively through the SUV or standard uptake value. The definitive diagnosis was confirmed through an anatomopathological study in 13 cases and through clinical follow up in the rest with an average of 11.2±5.4 months (range 6-24). Results. A CA-125 value higher than 35 UI/ml was considered positive, obtaining a sensitivity of 77% and a specificity of 100%. The sensitivity of the CAT was 23% and the specificity 91%. With the FDG-PET sensitivity was 92% and the specificity 90%. A SUV value ≥ 3 was considered pathological, obtaining the same results as with the visual evaluation. The FDG-PET was positive in 5 patients with non-conclusive CAT, 4 with negative CAT and 2 with negative CA-125. Conclusion. These preliminary results suggest that the FDG-PET could be useful in the follow up of patients treated for cancer of the ovary. The FDG-PET could be efficient in the differentiation between residual disease or recurrence, as opposed to sequels to the treatment, when the CAT is not conclusive due to anatomical distortion. The FDG-PET could be more sensitive than an increased marker value, and facing an increase of the latter it permits a non-invasive localisation of the disease.Gobierno de Navarra. Departamento de SaludDadun. Depósito Académico Digital Universidad de Navarra20122012-06-1620022002-01-0120022002-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/22582reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/225822026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario Clinical value of positron emission tomography with F-18-FDG in the follow up of patients with cancer of the ovary |
| title |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario |
| spellingShingle |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario Garcia-Velloso, M. J. (María José)|||/items/95484946-2b37-4f2a-943f-fc76c5b2aa8b Fluorodeoxyglucose Positron emission tomography Cancer of the ovary |
| title_short |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario |
| title_full |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario |
| title_fullStr |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario |
| title_full_unstemmed |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario |
| title_sort |
Valor clínico de la tomografía de emisión de positrones con F-18-FDG en el seguimiento de pacientes con cáncer de ovario |
| dc.creator.none.fl_str_mv |
Garcia-Velloso, M. J. (María José)|||/items/95484946-2b37-4f2a-943f-fc76c5b2aa8b Lopez-Garcia, G. (Guillermo)|||/items/3d04f46d-26ab-4df5-a248-9c2848336522 Galan, M.J. (M. J.)|||/items/42c4cf76-d4cf-4d0e-aff8-fb582447f741 Meiriño-Seoane, R.M. (Rosa María)|||/items/36afeff9-1fe2-4b0c-8711-b546e32e477e Marti-Climent, J.M. (Josep María)|||/items/dfc511a4-aa92-44b5-8624-17b03d0f3466 Boan, J. (J.)|||/items/7a61ba1b-31f3-45c1-b8a8-8697bccf2482 Richter, J.A. (José Ángel)|||/items/4b21b403-ba6f-4220-8493-3453c8f876c3 |
| author |
Garcia-Velloso, M. J. (María José)|||/items/95484946-2b37-4f2a-943f-fc76c5b2aa8b |
| author_facet |
Garcia-Velloso, M. J. (María José)|||/items/95484946-2b37-4f2a-943f-fc76c5b2aa8b Lopez-Garcia, G. (Guillermo)|||/items/3d04f46d-26ab-4df5-a248-9c2848336522 Galan, M.J. (M. J.)|||/items/42c4cf76-d4cf-4d0e-aff8-fb582447f741 Meiriño-Seoane, R.M. (Rosa María)|||/items/36afeff9-1fe2-4b0c-8711-b546e32e477e Marti-Climent, J.M. (Josep María)|||/items/dfc511a4-aa92-44b5-8624-17b03d0f3466 Boan, J. (J.)|||/items/7a61ba1b-31f3-45c1-b8a8-8697bccf2482 Richter, J.A. (José Ángel)|||/items/4b21b403-ba6f-4220-8493-3453c8f876c3 |
| author_role |
author |
| author2 |
Lopez-Garcia, G. (Guillermo)|||/items/3d04f46d-26ab-4df5-a248-9c2848336522 Galan, M.J. (M. J.)|||/items/42c4cf76-d4cf-4d0e-aff8-fb582447f741 Meiriño-Seoane, R.M. (Rosa María)|||/items/36afeff9-1fe2-4b0c-8711-b546e32e477e Marti-Climent, J.M. (Josep María)|||/items/dfc511a4-aa92-44b5-8624-17b03d0f3466 Boan, J. (J.)|||/items/7a61ba1b-31f3-45c1-b8a8-8697bccf2482 Richter, J.A. (José Ángel)|||/items/4b21b403-ba6f-4220-8493-3453c8f876c3 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Fluorodeoxyglucose Positron emission tomography Cancer of the ovary |
| topic |
Fluorodeoxyglucose Positron emission tomography Cancer of the ovary |
| description |
Background. Positron emission tomography with fluor- 18-deoxyglucose (PET-FDG) is an efficient technique for the detection of tumoural tissue. The aim of the paper is to evaluate the PET-FDG in the diagnosis of residual disease or relapse in patients with cancer of the ovary. Methods. A total of 24 patients, diagnosed and treated for cancer of the ovary with surgery and subsequent chemotherapy, were included. With 12 patients the study was carried out prior to second-look surgery, and with the other 12 after objectivising an increase of the tumoural marker in the follow up. Abdominal-pelvic CAT, determination of the seric levels of CA-125 and PET-FDG of thorax, abdomen and pelvis were carried out on all patients. The PET-FDG was evaluated in a qualitative way through the visual study of the images, and quantitatively through the SUV or standard uptake value. The definitive diagnosis was confirmed through an anatomopathological study in 13 cases and through clinical follow up in the rest with an average of 11.2±5.4 months (range 6-24). Results. A CA-125 value higher than 35 UI/ml was considered positive, obtaining a sensitivity of 77% and a specificity of 100%. The sensitivity of the CAT was 23% and the specificity 91%. With the FDG-PET sensitivity was 92% and the specificity 90%. A SUV value ≥ 3 was considered pathological, obtaining the same results as with the visual evaluation. The FDG-PET was positive in 5 patients with non-conclusive CAT, 4 with negative CAT and 2 with negative CA-125. Conclusion. These preliminary results suggest that the FDG-PET could be useful in the follow up of patients treated for cancer of the ovary. The FDG-PET could be efficient in the differentiation between residual disease or recurrence, as opposed to sequels to the treatment, when the CAT is not conclusive due to anatomical distortion. The FDG-PET could be more sensitive than an increased marker value, and facing an increase of the latter it permits a non-invasive localisation of the disease. |
| publishDate |
2002 |
| dc.date.none.fl_str_mv |
2002 2002-01-01 2002 2002-01-01 2012 2012-06-16 |
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journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10171/22582 |
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https://hdl.handle.net/10171/22582 |
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Español spa |
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Español |
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spa |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Gobierno de Navarra. Departamento de Salud |
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Gobierno de Navarra. Departamento de Salud |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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