Influence of the degree of anaemia on the prognosis of older adults with heart failure (SPAN-HF study)

Objective To assess whether a sustained optimal haemoglobin value in the 3 months after admission for heart failure (HF) decompensation reduces morbidity and mortality during the 12 months after admission for acute HF. Patients and method Retrospective study of the 1408 patients older than 65 years...

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Detalles Bibliográficos
Autores: Grau Amorós, Jordi, García García, José Ángel, Mira, Jose A., Serrado Iglesias, Anna, Moreno García, Mª Carmen, Manzano, Luis, Quesada Simón, Maria Angustias, Dávila Ramos, Melitón Francisco, Casado Cerrada, Jesús, González Franco, Álvaro, Montero-Pérez-Barquero, Manuel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/176947
Acceso en línea:https://hdl.handle.net/11441/176947
https://doi.org/10.1016/j.medcle.2021.01.025
Access Level:acceso abierto
Palabra clave:Anaemia
Anemia
Heart failure
Insuficiencia cardíaca
Morbidity
Morbilidad
Mortalidad
Mortality
Prognosis
Pronóstico
Descripción
Sumario:Objective To assess whether a sustained optimal haemoglobin value in the 3 months after admission for heart failure (HF) decompensation reduces morbidity and mortality during the 12 months after admission for acute HF. Patients and method Retrospective study of the 1408 patients older than 65 years included in the RICA registry divided into 3 groups: no anaemia (group A), recovered anaemia (group B), and persistent anaemia (group C), according to haemoglobin levels on admission, and 3 months after discharge. Kaplan-Meier curves were constructed, comparing the groups using the log-rank test and a Cox regression model was performed to analyse survival. Results 578 (41.1%), 299 (21.2%) and 531 (37.7%) were included in groups A, B and C, respectively. We recorded a total of 768 deaths and readmissions. There were 23 (4%), 12 (4%) and 49 (9.2%), (p = 0.001) individuals who died due to HF and 154 (27%), 73 (24%) and 193 (36%) (P < 0.001) admissions for this pathology, respectively. Patients with persistent anaemia had a higher risk of death (RR 1.29, 95% CI 1.04−1.61, P = 0.024) or readmission (1.92, 95% CI 1.16–3, 19; P = 0.012) due to HF. Conclusions Persistent anaemia in the months after admission for HF increases morbidity and mortality in the subsequent year.

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