Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans

Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United States

Bibliographic Details
Authors: González Manzano, Susana, Ayuda Durán, María Begoña, Martín Sanz, Roberto, Garzón García, Lidia, Santos Buelga, Celestino, González Paramás, Ana María
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad de Salamanca (USAL)
Repository:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/162317
Online Access:http://hdl.handle.net/10366/162317
Access Level:Embargoed access
Keyword:Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
enfermedad de Alzheimer
id ES_b2b7ef4d159baaa76c8a369232c370a5
oai_identifier_str oai:gredos.usal.es:10366/162317
network_acronym_str ES
network_name_str España
repository_id_str
spelling Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegansGonzález Manzano, SusanaAyuda Durán, María BegoñaMartín Sanz, RobertoGarzón García, LidiaSantos Buelga, CelestinoGonzález Paramás, Ana MaríaAlzheimer’s diseaseCaenorhabditis elegansgrape seed polyphenolamyloid-βneuroprotectionproteostasisAlzheimer DiseaseCaenorhabditis elegansenfermedad de AlzheimerCaenorhabditis elegansSome strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United StatesAlzheimer’s disease (AD), a major neurodegenerative disorder, is characterized by the progressive accumulation of amyloid-β (Aβ) plaques, leading to cognitive decline. Despite the existing treatments, their limited efficacy highlights the urgent need for novel therapeutic strategies. The present study investigates the neuroprotective effects of a grape seed polyphenol extract (GSPE) on transgenic Caenorhabditis elegans models specifically expressing human Aβ proteins. The obtained results show that GSPE not only significantly attenuates Aβ-induced paralysis but also extends the lifespan and improves sensory responses in these models, suggesting improved neural function and overall health. Additionally, GSPE treatment reduces proteasomal activity, which could lead to a reduction in the accumulation of misfolded proteins. It also modulates the expression of key genes involved in autophagy and proteostasis, thereby enhancing cellular mechanisms to manage protein aggregation and combat oxidative stress. On the whole, these findings support the potential of grape seed procyanidins (the main components in the extract) to be used as an effective dietary approach to mitigate Alzheimer’s disease pathology through the modulation of critical neuroprotective pathways.Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United Stateshttps://www.mdpi.com/2304-8158/13/23/3865info202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/162317reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1623172026-06-07T06:28:51Z
dc.title.none.fl_str_mv Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
spellingShingle Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
González Manzano, Susana
Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
Caenorhabditis elegans
enfermedad de Alzheimer
Caenorhabditis elegans
title_short Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_full Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_fullStr Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_full_unstemmed Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_sort Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
dc.creator.none.fl_str_mv González Manzano, Susana
Ayuda Durán, María Begoña
Martín Sanz, Roberto
Garzón García, Lidia
Santos Buelga, Celestino
González Paramás, Ana María
author González Manzano, Susana
author_facet González Manzano, Susana
Ayuda Durán, María Begoña
Martín Sanz, Roberto
Garzón García, Lidia
Santos Buelga, Celestino
González Paramás, Ana María
author_role author
author2 Ayuda Durán, María Begoña
Martín Sanz, Roberto
Garzón García, Lidia
Santos Buelga, Celestino
González Paramás, Ana María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
Caenorhabditis elegans
enfermedad de Alzheimer
Caenorhabditis elegans
topic Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
Caenorhabditis elegans
enfermedad de Alzheimer
Caenorhabditis elegans
description Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United States
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/162317
url http://hdl.handle.net/10366/162317
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv https://www.mdpi.com/2304-8158/13/23/3865
publisher.none.fl_str_mv https://www.mdpi.com/2304-8158/13/23/3865
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417078718464000
score 15,812429

Similar Items