PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes

Cardiometabolic traits; Cardiovascular disease risk; Type 1 diabetes

Detalles Bibliográficos
Autores: Sardà, Helena, Colom, Cristina, Benitez, Sonia, Carreras, Gemma, Miñambres, Inka, Amigó, Judit
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/11288
Acceso en línea:https://hdl.handle.net/11351/11288
Access Level:acceso abierto
Palabra clave:Diabetis
Metabolisme
Sistema cardiovascular - Malalties - Factors de risc
Teixit adipós
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1
Other subheadings::Other subheadings::Other subheadings::/metabolism
ANATOMY::Tissues::Connective Tissue::Adipose Tissue
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo I
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
ANATOMÍA::tejidos::tejido conectivo::tejido adiposo
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/11288
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
title PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
spellingShingle PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
Sardà, Helena
Diabetis
Metabolisme
Sistema cardiovascular - Malalties - Factors de risc
Teixit adipós
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1
Other subheadings::Other subheadings::Other subheadings::/metabolism
ANATOMY::Tissues::Connective Tissue::Adipose Tissue
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo I
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
ANATOMÍA::tejidos::tejido conectivo::tejido adiposo
title_short PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
title_full PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
title_fullStr PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
title_full_unstemmed PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
title_sort PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
dc.creator.none.fl_str_mv Sardà, Helena
Colom, Cristina
Benitez, Sonia
Carreras, Gemma
Miñambres, Inka
Amigó, Judit
author Sardà, Helena
author_facet Sardà, Helena
Colom, Cristina
Benitez, Sonia
Carreras, Gemma
Miñambres, Inka
Amigó, Judit
author_role author
author2 Colom, Cristina
Benitez, Sonia
Carreras, Gemma
Miñambres, Inka
Amigó, Judit
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Sardà H] Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau - Hospital Dos de Maig, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Colom C] Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau - Hospital Dos de Maig, Barcelona, Spain. [Benitez S] Cardiovascular Biochemistry Group, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain. CIBER en Diabetes y Enfermedades Metabólicas (CIBERDEM), Madrid, Spain. [Carreras G] Department of Pediatrics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Departament de Pediatria, Obstetrícia i Ginecologia, Medicina Preventiva i Salut Pública, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Amigó J] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Miñambres I] Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau - Hospital Dos de Maig, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER en Diabetes y Enfermedades Metabólicas (CIBERDEM), Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Diabetis
Metabolisme
Sistema cardiovascular - Malalties - Factors de risc
Teixit adipós
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1
Other subheadings::Other subheadings::Other subheadings::/metabolism
ANATOMY::Tissues::Connective Tissue::Adipose Tissue
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo I
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
ANATOMÍA::tejidos::tejido conectivo::tejido adiposo
topic Diabetis
Metabolisme
Sistema cardiovascular - Malalties - Factors de risc
Teixit adipós
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1
Other subheadings::Other subheadings::Other subheadings::/metabolism
ANATOMY::Tissues::Connective Tissue::Adipose Tissue
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo I
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
ANATOMÍA::tejidos::tejido conectivo::tejido adiposo
description Cardiometabolic traits; Cardiovascular disease risk; Type 1 diabetes
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/11288
url https://hdl.handle.net/11351/11288
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports;14
https://doi.org/10.1038/s41598-024-57708-5
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Portfolio
publisher.none.fl_str_mv Nature Portfolio
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417065593438208
spelling PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetesSardà, HelenaColom, CristinaBenitez, SoniaCarreras, GemmaMiñambres, InkaAmigó, JuditDiabetisMetabolismeSistema cardiovascular - Malalties - Factors de riscTeixit adipósDISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1Other subheadings::Other subheadings::Other subheadings::/metabolismANATOMY::Tissues::Connective Tissue::Adipose TissueENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo IOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoANATOMÍA::tejidos::tejido conectivo::tejido adiposoCardiometabolic traits; Cardiovascular disease risk; Type 1 diabetesTrets cardiometabòlics; Risc de malaltia cardiovascular; Diabetis tipus 1Rasgos cardiometabólicos; Riesgo de enfermedad cardiovascular; Diabetes tipo 1Patients with type 1 diabetes (T1D) have a greater risk of cardiovascular disease. Proconvertase subtilisin-kexin 9 (PCSK9) is involved in the atherosclerosis process. This study aimed to determine the relationship between PCSK9 levels and epicardial adipose tissue (EAT) volume and cardiometabolic variables in patients with T1D. This was an observational cross-sectional study including 73 patients with T1D. Clinical, biochemical and imaging data were collected. We divided the patients into two groups according to their glycemic control and the EAT index (iEAT) percentile. We performed a correlation analysis between the collected variables and PCSK9 levels; subsequently, we performed a multiple regression analysis with the significant parameters. The mean age was 47.6 ± 8.5 years, 58.9% were men, and the BMI was 26.9 ± 4.6 kg/m2. A total of 31.5%, 49.3% and 34.2% of patients had hypertension, dyslipidemia and smoking habit, respectively. The PCSK9 concentration was 0.37 ± 0.12 mg/L, which was greater in patients with worse glycemic control (HbA1c > 7.5%), dyslipidemia and high EAT volume (iEAT > 75th percentile). The PCSK9 concentration was positively correlated with age (r = 0.259; p = 0.027), HbA1c (r = 0.300; p = 0.011), insulin dose (r = 0.275; p = 0.020), VLDL-C level (r = 0.331; p = 0.004), TG level (r = 0.328; p = 0.005), and iEAT (r = 0.438; p < 0.001). Multiple regression analysis revealed that 25% of the PCSK9 variability was explained by iEAT and HbA1c (p < 0.05). The PCSK9 concentration is associated with metabolic syndrome parameters, poor glycemic control and increased EAT volume in patients with T1D.This work was supported by FIS PI16/00471 and PI20/00334 from the Instituto de Salud Carlos III/Ministry of Health, co-financed by the European Regional Development Fund (FEDER “A way to make Europe”/“Investing in your future”) and a grant from the Sociedad Española de Diabetes (SED). CIBERDEM (CB07/08/0016) is an Instituto de Salud Carlos III Project.Nature PortfolioInstitut Català de la Salut[Sardà H] Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau - Hospital Dos de Maig, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Colom C] Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau - Hospital Dos de Maig, Barcelona, Spain. [Benitez S] Cardiovascular Biochemistry Group, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain. CIBER en Diabetes y Enfermedades Metabólicas (CIBERDEM), Madrid, Spain. [Carreras G] Department of Pediatrics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Departament de Pediatria, Obstetrícia i Ginecologia, Medicina Preventiva i Salut Pública, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Amigó J] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Miñambres I] Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau - Hospital Dos de Maig, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER en Diabetes y Enfermedades Metabólicas (CIBERDEM), Madrid, SpainVall d'Hebron Barcelona Hospital Campus202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/11288Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésScientific Reports;14https://doi.org/10.1038/s41598-024-57708-5Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/112882026-06-12T09:38:37Z
score 15,811543

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