Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep

After oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep w...

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Autores: Castaño, Pablo, Fuertes ,Miguel, Ferré Pérez, Ignacio, Fernández, Miguel, Ferreras, Maria del Carmen, Moreno Gonzalo, Javier, González-Lanza, Camino, Katzer, Frank, Regidor-Cerrillo, Javier, Ortega Mora, Luis Miguel, Pérez, Valentín, Benavides ,Julio
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/100607
Acesso em linha:https://hdl.handle.net/20.500.14352/100607
Access Level:acceso abierto
Palavra-chave:Toxoplasmosis
Abort Foetus
Periventricular Leukomalacia
Infected Sheep
Microscopic Lesion
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
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spelling Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheepCastaño, PabloFuertes ,MiguelFerré Pérez, IgnacioFernández, MiguelFerreras, Maria del CarmenMoreno Gonzalo, JavierGonzález-Lanza, CaminoKatzer, FrankRegidor-Cerrillo, JavierOrtega Mora, Luis MiguelPérez, ValentínBenavides ,JulioToxoplasmosisAbort FoetusPeriventricular LeukomalaciaInfected SheepMicroscopic LesionVeterinariaPatología veterinaria3109 Ciencias VeterinariasAfter oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence of the isolate may play a role in their development.BMCUniversidad Complutense de Madrid20142014-01-2920142014-01-29journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/100607reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1006072026-06-02T12:44:21Z
dc.title.none.fl_str_mv Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
title Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
spellingShingle Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
Castaño, Pablo
Toxoplasmosis
Abort Foetus
Periventricular Leukomalacia
Infected Sheep
Microscopic Lesion
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
title_short Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
title_full Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
title_fullStr Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
title_full_unstemmed Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
title_sort Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
dc.creator.none.fl_str_mv Castaño, Pablo
Fuertes ,Miguel
Ferré Pérez, Ignacio
Fernández, Miguel
Ferreras, Maria del Carmen
Moreno Gonzalo, Javier
González-Lanza, Camino
Katzer, Frank
Regidor-Cerrillo, Javier
Ortega Mora, Luis Miguel
Pérez, Valentín
Benavides ,Julio
author Castaño, Pablo
author_facet Castaño, Pablo
Fuertes ,Miguel
Ferré Pérez, Ignacio
Fernández, Miguel
Ferreras, Maria del Carmen
Moreno Gonzalo, Javier
González-Lanza, Camino
Katzer, Frank
Regidor-Cerrillo, Javier
Ortega Mora, Luis Miguel
Pérez, Valentín
Benavides ,Julio
author_role author
author2 Fuertes ,Miguel
Ferré Pérez, Ignacio
Fernández, Miguel
Ferreras, Maria del Carmen
Moreno Gonzalo, Javier
González-Lanza, Camino
Katzer, Frank
Regidor-Cerrillo, Javier
Ortega Mora, Luis Miguel
Pérez, Valentín
Benavides ,Julio
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Toxoplasmosis
Abort Foetus
Periventricular Leukomalacia
Infected Sheep
Microscopic Lesion
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
topic Toxoplasmosis
Abort Foetus
Periventricular Leukomalacia
Infected Sheep
Microscopic Lesion
Veterinaria
Patología veterinaria
3109 Ciencias Veterinarias
description After oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence of the isolate may play a role in their development.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-29
2014
2014-01-29
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/100607
url https://hdl.handle.net/20.500.14352/100607
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417063969193984
score 15,301603

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