Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain

Pneumococcal pneumonia is a serious cause of morbidity and mortality in the elderly, but investigation of the etiological agent of community-acquired pneumonia (CAP) is not possible in most hospitalized patients. The aim of this study was to estimate the effect of pneumococcal polysaccharide vaccina...

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Autores: Domínguez García, Àngela, Soldevila, Núria, Toledo Zavaleta, Diana Isabel, Torner Gràcia, Núria, Force, Lluís, Pérez Lozano, María José, Martín Sánchez, Vicente, Rodríguez Rojas, Lourdes, Astray, Jenaro, Egurrola, Mikel, Sanz, Francisco, Castilla, Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/120590
Acceso en línea:https://hdl.handle.net/2445/120590
Access Level:acceso abierto
Palabra clave:Vacunes
Pneumònia
Polisacàrids
Persones grans
Vaccines
Pneumonia
Polysaccharides
Older people
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spelling Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in SpainDomínguez García, ÀngelaSoldevila, NúriaToledo Zavaleta, Diana IsabelTorner Gràcia, NúriaForce, LluísPérez Lozano, María JoséMartín Sánchez, VicenteRodríguez Rojas, LourdesAstray, JenaroEgurrola, MikelSanz, FranciscoCastilla, JesúsVacunesPneumòniaPolisacàridsPersones gransVaccinesPneumoniaPolysaccharidesOlder peoplePneumococcal pneumonia is a serious cause of morbidity and mortality in the elderly, but investigation of the etiological agent of community-acquired pneumonia (CAP) is not possible in most hospitalized patients. The aim of this study was to estimate the effect of pneumococcal polysaccharide vaccination (PPSV23) in preventing CAP hospitalization and reducing the risk of intensive care unit admission (ICU) and fatal outcomes in hospitalized people aged 65 years. We made a multicenter case-control study in 20 Spanish hospitals during 2013-2014 and 2014-2015. We selected patients aged 65 years hospitalized with a diagnosis of pneumonia and controls matched by sex, age and date of hospitalization. Multivariate analysis was performed using conditional logistic regression to estimate vaccine effectiveness and unconditional logistic regression to evaluate the reduction in the risk of severe and fatal outcomes. 1895 cases and 1895 controls were included; 13.7% of cases and 14.4% of controls had received PPSV23 in the last five years. The effectiveness of PPSV23 in preventing CAP hospitalization was 15.2% (95% CI -3.1-30.3). The benefit of PPSV23 in avoiding ICU admission or death was 28.1% (95% CI -14.3-56.9) in all patients, 30.9% (95% CI -32.2-67.4) in immunocompetent patients and 26.9% (95% CI -38.6-64.8) in immunocompromised patients. In conclusion, PPSV23 showed a modest trend to avoidance of hospitalizations due to CAP and to the prevention of death or ICU admission in elderly patients hospitalized with a diagnosis of CAP.Public Library of Science (PLoS)2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/120590Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0171943PLoS One, 2017, vol. 12, num. 2, p. e0171943https://doi.org/10.1371/journal.pone.0171943cc-by (c) Domínguez García, Àngela et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1205902026-05-27T06:46:51Z
dc.title.none.fl_str_mv Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
title Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
spellingShingle Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
Domínguez García, Àngela
Vacunes
Pneumònia
Polisacàrids
Persones grans
Vaccines
Pneumonia
Polysaccharides
Older people
title_short Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
title_full Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
title_fullStr Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
title_full_unstemmed Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
title_sort Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
dc.creator.none.fl_str_mv Domínguez García, Àngela
Soldevila, Núria
Toledo Zavaleta, Diana Isabel
Torner Gràcia, Núria
Force, Lluís
Pérez Lozano, María José
Martín Sánchez, Vicente
Rodríguez Rojas, Lourdes
Astray, Jenaro
Egurrola, Mikel
Sanz, Francisco
Castilla, Jesús
author Domínguez García, Àngela
author_facet Domínguez García, Àngela
Soldevila, Núria
Toledo Zavaleta, Diana Isabel
Torner Gràcia, Núria
Force, Lluís
Pérez Lozano, María José
Martín Sánchez, Vicente
Rodríguez Rojas, Lourdes
Astray, Jenaro
Egurrola, Mikel
Sanz, Francisco
Castilla, Jesús
author_role author
author2 Soldevila, Núria
Toledo Zavaleta, Diana Isabel
Torner Gràcia, Núria
Force, Lluís
Pérez Lozano, María José
Martín Sánchez, Vicente
Rodríguez Rojas, Lourdes
Astray, Jenaro
Egurrola, Mikel
Sanz, Francisco
Castilla, Jesús
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vacunes
Pneumònia
Polisacàrids
Persones grans
Vaccines
Pneumonia
Polysaccharides
Older people
topic Vacunes
Pneumònia
Polisacàrids
Persones grans
Vaccines
Pneumonia
Polysaccharides
Older people
description Pneumococcal pneumonia is a serious cause of morbidity and mortality in the elderly, but investigation of the etiological agent of community-acquired pneumonia (CAP) is not possible in most hospitalized patients. The aim of this study was to estimate the effect of pneumococcal polysaccharide vaccination (PPSV23) in preventing CAP hospitalization and reducing the risk of intensive care unit admission (ICU) and fatal outcomes in hospitalized people aged 65 years. We made a multicenter case-control study in 20 Spanish hospitals during 2013-2014 and 2014-2015. We selected patients aged 65 years hospitalized with a diagnosis of pneumonia and controls matched by sex, age and date of hospitalization. Multivariate analysis was performed using conditional logistic regression to estimate vaccine effectiveness and unconditional logistic regression to evaluate the reduction in the risk of severe and fatal outcomes. 1895 cases and 1895 controls were included; 13.7% of cases and 14.4% of controls had received PPSV23 in the last five years. The effectiveness of PPSV23 in preventing CAP hospitalization was 15.2% (95% CI -3.1-30.3). The benefit of PPSV23 in avoiding ICU admission or death was 28.1% (95% CI -14.3-56.9) in all patients, 30.9% (95% CI -32.2-67.4) in immunocompetent patients and 26.9% (95% CI -38.6-64.8) in immunocompromised patients. In conclusion, PPSV23 showed a modest trend to avoidance of hospitalizations due to CAP and to the prevention of death or ICU admission in elderly patients hospitalized with a diagnosis of CAP.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120590
url https://hdl.handle.net/2445/120590
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0171943
PLoS One, 2017, vol. 12, num. 2, p. e0171943
https://doi.org/10.1371/journal.pone.0171943
dc.rights.none.fl_str_mv cc-by (c) Domínguez García, Àngela et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Domínguez García, Àngela et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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