Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk

Individuals with dementia and neurodegenerative diseases (NDDs) often suffer from cardiovascular diseases (CVDs). Neuroinflammation driven by conditions involved in CVDs is linked to disruptions in the central nervous system triggering immune reactions, perpetuating an inflammatory-like environment....

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Autores: Hernando Redondo, Javier, Malcampo, Mireia, Pérez Vega, Karla Alejandra, Paz Graniel, Indira, Martínez-González, Miguel Ángel, 1957-, Corella, Dolores, Estruch Riba, Ramon, Salas Salvadó, Jordi, Pintó Sala, Xavier, Arós, Fernando, Bautista Castaño, Inmaculada, Romaguera, Dora, Lapetra, José, Ros Rahola, Emilio, Cueto Galán, Raquel, Fitó, Montserrat, Castañer, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/215928
Acceso en línea:https://hdl.handle.net/2445/215928
Access Level:acceso abierto
Palabra clave:Cuina mediterrània
Inflamació
Mediterranean cooking
Inflammation
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spelling Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular RiskHernando Redondo, JavierMalcampo, MireiaPérez Vega, Karla AlejandraPaz Graniel, IndiraMartínez-González, Miguel Ángel, 1957-Corella, DoloresEstruch Riba, RamonSalas Salvadó, JordiPintó Sala, XavierArós, FernandoBautista Castaño, InmaculadaRomaguera, DoraLapetra, JoséRos Rahola, EmilioCueto Galán, RaquelFitó, MontserratCastañer, OlgaCuina mediterràniaInflamacióMediterranean cookingInflammationIndividuals with dementia and neurodegenerative diseases (NDDs) often suffer from cardiovascular diseases (CVDs). Neuroinflammation driven by conditions involved in CVDs is linked to disruptions in the central nervous system triggering immune reactions, perpetuating an inflammatory-like environment. The Mediterranean diet (MedDiet), known for its anti-inflammatory and antioxidant properties, has been proposed as a key factor to attenuate these risks. Blood nuclear cell samples were collected from 134 participants of the PREDIMED trial, which randomized participants to three diets: one supplemented with extra-virgin olive oil (MedDiet-EVOO), another with nuts (MedDiet-Nuts), and a low-fat control diet. These samples were analyzed at baseline and 12-month follow-up to assess the impact of these dietary interventions on gene expression markers. We first selected target genes by analyzing intersections between NDD and CVD associations. Significant gene expression changes from baseline to 12 months were observed in the participants allocated to the MedDiet-EVOO, particularly in CDKN2A, IFNG, NLRP3, PIK3CB, and TGFB2. Additionally, TGFB2 expression changed over time in the MedDiet-Nuts group. Comparative analyses showed significant differences in TGFB2 between MedDiet-EVOO and control, and in NAMPT between MedDiet-Nuts and control. Longitudinal models adjusted for different covariates also revealed significant effects for TGFB2 and NAMPT. In conclusion, our results suggest that one year of traditional MedDiet, especially MedDiet-EVOO, modulates gene expression associated with CVD risk and NDDs in older adults at high CV risk.MDPI AG2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/215928Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu16183147Nutrients, 2024, vol. 16, num. 18, p. 3147https://doi.org/10.3390/nu16183147cc by (c) Hernando Redondo, Javier et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2159282026-05-27T06:46:51Z
dc.title.none.fl_str_mv Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
title Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
spellingShingle Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
Hernando Redondo, Javier
Cuina mediterrània
Inflamació
Mediterranean cooking
Inflammation
title_short Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
title_full Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
title_fullStr Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
title_full_unstemmed Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
title_sort Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk
dc.creator.none.fl_str_mv Hernando Redondo, Javier
Malcampo, Mireia
Pérez Vega, Karla Alejandra
Paz Graniel, Indira
Martínez-González, Miguel Ángel, 1957-
Corella, Dolores
Estruch Riba, Ramon
Salas Salvadó, Jordi
Pintó Sala, Xavier
Arós, Fernando
Bautista Castaño, Inmaculada
Romaguera, Dora
Lapetra, José
Ros Rahola, Emilio
Cueto Galán, Raquel
Fitó, Montserrat
Castañer, Olga
author Hernando Redondo, Javier
author_facet Hernando Redondo, Javier
Malcampo, Mireia
Pérez Vega, Karla Alejandra
Paz Graniel, Indira
Martínez-González, Miguel Ángel, 1957-
Corella, Dolores
Estruch Riba, Ramon
Salas Salvadó, Jordi
Pintó Sala, Xavier
Arós, Fernando
Bautista Castaño, Inmaculada
Romaguera, Dora
Lapetra, José
Ros Rahola, Emilio
Cueto Galán, Raquel
Fitó, Montserrat
Castañer, Olga
author_role author
author2 Malcampo, Mireia
Pérez Vega, Karla Alejandra
Paz Graniel, Indira
Martínez-González, Miguel Ángel, 1957-
Corella, Dolores
Estruch Riba, Ramon
Salas Salvadó, Jordi
Pintó Sala, Xavier
Arós, Fernando
Bautista Castaño, Inmaculada
Romaguera, Dora
Lapetra, José
Ros Rahola, Emilio
Cueto Galán, Raquel
Fitó, Montserrat
Castañer, Olga
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cuina mediterrània
Inflamació
Mediterranean cooking
Inflammation
topic Cuina mediterrània
Inflamació
Mediterranean cooking
Inflammation
description Individuals with dementia and neurodegenerative diseases (NDDs) often suffer from cardiovascular diseases (CVDs). Neuroinflammation driven by conditions involved in CVDs is linked to disruptions in the central nervous system triggering immune reactions, perpetuating an inflammatory-like environment. The Mediterranean diet (MedDiet), known for its anti-inflammatory and antioxidant properties, has been proposed as a key factor to attenuate these risks. Blood nuclear cell samples were collected from 134 participants of the PREDIMED trial, which randomized participants to three diets: one supplemented with extra-virgin olive oil (MedDiet-EVOO), another with nuts (MedDiet-Nuts), and a low-fat control diet. These samples were analyzed at baseline and 12-month follow-up to assess the impact of these dietary interventions on gene expression markers. We first selected target genes by analyzing intersections between NDD and CVD associations. Significant gene expression changes from baseline to 12 months were observed in the participants allocated to the MedDiet-EVOO, particularly in CDKN2A, IFNG, NLRP3, PIK3CB, and TGFB2. Additionally, TGFB2 expression changed over time in the MedDiet-Nuts group. Comparative analyses showed significant differences in TGFB2 between MedDiet-EVOO and control, and in NAMPT between MedDiet-Nuts and control. Longitudinal models adjusted for different covariates also revealed significant effects for TGFB2 and NAMPT. In conclusion, our results suggest that one year of traditional MedDiet, especially MedDiet-EVOO, modulates gene expression associated with CVD risk and NDDs in older adults at high CV risk.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/215928
url https://hdl.handle.net/2445/215928
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu16183147
Nutrients, 2024, vol. 16, num. 18, p. 3147
https://doi.org/10.3390/nu16183147
dc.rights.none.fl_str_mv cc by (c) Hernando Redondo, Javier et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Hernando Redondo, Javier et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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