An: In vivo study on bone formation behavior of microporous granular calcium phosphate
This study was developed based on in vivo investigation of microporous granular biomaterials based on calcium phosphates, involving matrices of β-tricalcium phosphate (β-TCP), hydroxyapatite (HA), biphasic compositions of both phases and a control group. The physicochemical characterization of mater...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/419545 |
| Acceso en línea: | http://hdl.handle.net/10261/419545 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021760889&doi=10.1039%2Fc7bm00162b&partnerID=40&md5=13141a967400022a6ea2993606f74554 |
| Access Level: | acceso abierto |
| Palabra clave: | Calcium Phosphate Biphasic Microstructure Bone Neoformation Characterization |
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An: In vivo study on bone formation behavior of microporous granular calcium phosphateDalmônico, G.M.L.Franczak, P.F.Levandowski, N.Camargo, N.H.A.Dallabrida, A.L.da Costa, B.D.Gil, O.G.Cambra-Moo, O.Rodríguez, M.A.Canillas Pérez, MaríaCalcium PhosphateBiphasicMicrostructureBone NeoformationCharacterizationThis study was developed based on in vivo investigation of microporous granular biomaterials based on calcium phosphates, involving matrices of β-tricalcium phosphate (β-TCP), hydroxyapatite (HA), biphasic compositions of both phases and a control group. The physicochemical characterization of materials was carried out by X-Ray diffraction (DRX) and mercury porosimetry. Biodegradability, bioactivity and neoformation processes were investigated by Raman spectroscopy, scanning electron microscopy (SEM) and polarized light conducted on biopsies obtained from in vivo tests for periods of 90 and 180 days. These were performed to evaluate the behavior of granular microporous compositions in relation to bone neoformation. Through the performance obtained from in vivo assays, excellent osseointegration and bone tissue neoformation were observed. The results are encouraging and show that the microporous granular biomaterials of HA, β-TCP and biphasic compositions show similar results with perfect osseointegration. Architectures simulating a bone structure can make the difference between biomaterials for bone tissue replacement and repair. © 2017 The Royal Society of Chemistry.The financial support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-BRASIL) and the Ministry of Economy and Competitiveness from the Spanish Government (MAT2013-48426-C2-1R) for the assistance in the characterization of the biomaterials before and after the in vivo tests is acknowledged.Peer reviewedRoyal Society of Chemistry (UK)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/419545https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021760889&doi=10.1039%2Fc7bm00162b&partnerID=40&md5=13141a967400022a6ea2993606f74554reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//Biomaterials Sciencehttps://doi.org/10.1039/C7BM00162BSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4195452026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| title |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| spellingShingle |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate Dalmônico, G.M.L. Calcium Phosphate Biphasic Microstructure Bone Neoformation Characterization |
| title_short |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| title_full |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| title_fullStr |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| title_full_unstemmed |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| title_sort |
An: In vivo study on bone formation behavior of microporous granular calcium phosphate |
| dc.creator.none.fl_str_mv |
Dalmônico, G.M.L. Franczak, P.F. Levandowski, N. Camargo, N.H.A. Dallabrida, A.L. da Costa, B.D. Gil, O.G. Cambra-Moo, O. Rodríguez, M.A. Canillas Pérez, María |
| author |
Dalmônico, G.M.L. |
| author_facet |
Dalmônico, G.M.L. Franczak, P.F. Levandowski, N. Camargo, N.H.A. Dallabrida, A.L. da Costa, B.D. Gil, O.G. Cambra-Moo, O. Rodríguez, M.A. Canillas Pérez, María |
| author_role |
author |
| author2 |
Franczak, P.F. Levandowski, N. Camargo, N.H.A. Dallabrida, A.L. da Costa, B.D. Gil, O.G. Cambra-Moo, O. Rodríguez, M.A. Canillas Pérez, María |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) Ministerio de Economía y Competitividad (España) Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Calcium Phosphate Biphasic Microstructure Bone Neoformation Characterization |
| topic |
Calcium Phosphate Biphasic Microstructure Bone Neoformation Characterization |
| description |
This study was developed based on in vivo investigation of microporous granular biomaterials based on calcium phosphates, involving matrices of β-tricalcium phosphate (β-TCP), hydroxyapatite (HA), biphasic compositions of both phases and a control group. The physicochemical characterization of materials was carried out by X-Ray diffraction (DRX) and mercury porosimetry. Biodegradability, bioactivity and neoformation processes were investigated by Raman spectroscopy, scanning electron microscopy (SEM) and polarized light conducted on biopsies obtained from in vivo tests for periods of 90 and 180 days. These were performed to evaluate the behavior of granular microporous compositions in relation to bone neoformation. Through the performance obtained from in vivo assays, excellent osseointegration and bone tissue neoformation were observed. The results are encouraging and show that the microporous granular biomaterials of HA, β-TCP and biphasic compositions show similar results with perfect osseointegration. Architectures simulating a bone structure can make the difference between biomaterials for bone tissue replacement and repair. © 2017 The Royal Society of Chemistry. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Postprint info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/419545 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021760889&doi=10.1039%2Fc7bm00162b&partnerID=40&md5=13141a967400022a6ea2993606f74554 |
| url |
http://hdl.handle.net/10261/419545 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021760889&doi=10.1039%2Fc7bm00162b&partnerID=40&md5=13141a967400022a6ea2993606f74554 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI// Biomaterials Science https://doi.org/10.1039/C7BM00162B Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Royal Society of Chemistry (UK) |
| publisher.none.fl_str_mv |
Royal Society of Chemistry (UK) |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869417021011132416 |
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15,811543 |