An inside out journey: biogenesis, ultrastructure and proteomic characterisation of the ectoparasitic flatworm Sparicotyle chrysophrii extracellular vesicles

[Background]: Helminth extracellular vesicles (EVs) are known to have a three-way communication function among parasitic helminths, their host and the host-associated microbiota. They are considered biological containers that may carry virulence factors, being therefore appealing as therapeutic and...

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Detalles Bibliográficos
Autores: Riera-Ferrer, E., Mazanec, Hynek, Mladineo, Ivona, Konik, Peter, Piazzon de Haro, María Carla, Kuchta, Roman, Palenzuela, Oswaldo, Estensoro, Itziar, Sotillo, Javier, Sitjà-Bobadilla, Ariadna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/358326
Acceso en línea:http://hdl.handle.net/10261/358326
Access Level:acceso abierto
Palabra clave:Monogenea
Polyopisthocotyla
Exosomes
Ectosomes
Electron microscopy
Drug target candidates
Prophylactic target candidates
Peptidases
Descripción
Sumario:[Background]: Helminth extracellular vesicles (EVs) are known to have a three-way communication function among parasitic helminths, their host and the host-associated microbiota. They are considered biological containers that may carry virulence factors, being therefore appealing as therapeutic and prophylactic target candidates. This study aims to describe and characterise EVs secreted by Sparicotyle chrysophrii (Polyopisthocotyla: Microcotylidae), a blood-feeding gill parasite of gilthead seabream (Sparus aurata), causing significant economic losses in Mediterranean aquaculture.

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