Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.

As the global population ages, the prevalence of neurodegenerative disorders is fast increasing. This neurodegeneration as well as other central nervous system (CNS) injuries cause permanent disabilities. Thus, generation of new neurons is the rosetta stone in contemporary neuroscience. Glial cells...

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Detalles Bibliográficos
Autores: Casas-Tinto, Sergio, Garcia-Guillen, Nuria, Losada-Perez, María
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/27152
Acceso en línea:https://hdl.handle.net/20.500.12105/27152
Access Level:acceso abierto
Palabra clave:CNS injury
D. melanogaster
Glia
Neuroscience
Regeneration
Transdifferentiation
Ventral nerve cord
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spelling Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.Casas-Tinto, SergioGarcia-Guillen, NuriaLosada-Perez, MaríaCNS injuryD. melanogasterGliaNeuroscienceRegenerationTransdifferentiationVentral nerve cordAs the global population ages, the prevalence of neurodegenerative disorders is fast increasing. This neurodegeneration as well as other central nervous system (CNS) injuries cause permanent disabilities. Thus, generation of new neurons is the rosetta stone in contemporary neuroscience. Glial cells support CNS homeostasis through evolutionary conserved mechanisms. Upon damage, glial cells activate an immune and inflammatory response to clear the injury site from debris and proliferate to restore cell number. This glial regenerative response (GRR) is mediated by the neuropil-associated glia (NG) in , equivalent to vertebrate astrocytes, oligodendrocytes (OL), and oligodendrocyte progenitor cells (OPCs). Here, we examine the contribution of NG lineages and the GRR in response to injury. The results indicate that NG exchanges identities between ensheathing glia (EG) and astrocyte-like glia (ALG). Additionally, we found that NG cells undergo transdifferentiation to yield neurons. Moreover, this transdifferentiation increases in injury conditions. Thus, these data demonstrate that glial cells are able to generate new neurons through direct transdifferentiation. The present work makes a fundamental contribution to the CNS regeneration field and describes a new physiological mechanism to generate new neurons.eLife Sciences Publications20262026-01-1620252025-03-0720252025-03-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/ziphttps://hdl.handle.net/20.500.12105/27152reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/271522026-06-12T12:43:37Z
dc.title.none.fl_str_mv Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
title Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
spellingShingle Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
Casas-Tinto, Sergio
CNS injury
D. melanogaster
Glia
Neuroscience
Regeneration
Transdifferentiation
Ventral nerve cord
title_short Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
title_full Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
title_fullStr Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
title_full_unstemmed Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
title_sort Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm.
dc.creator.none.fl_str_mv Casas-Tinto, Sergio
Garcia-Guillen, Nuria
Losada-Perez, María
author Casas-Tinto, Sergio
author_facet Casas-Tinto, Sergio
Garcia-Guillen, Nuria
Losada-Perez, María
author_role author
author2 Garcia-Guillen, Nuria
Losada-Perez, María
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv CNS injury
D. melanogaster
Glia
Neuroscience
Regeneration
Transdifferentiation
Ventral nerve cord
topic CNS injury
D. melanogaster
Glia
Neuroscience
Regeneration
Transdifferentiation
Ventral nerve cord
description As the global population ages, the prevalence of neurodegenerative disorders is fast increasing. This neurodegeneration as well as other central nervous system (CNS) injuries cause permanent disabilities. Thus, generation of new neurons is the rosetta stone in contemporary neuroscience. Glial cells support CNS homeostasis through evolutionary conserved mechanisms. Upon damage, glial cells activate an immune and inflammatory response to clear the injury site from debris and proliferate to restore cell number. This glial regenerative response (GRR) is mediated by the neuropil-associated glia (NG) in , equivalent to vertebrate astrocytes, oligodendrocytes (OL), and oligodendrocyte progenitor cells (OPCs). Here, we examine the contribution of NG lineages and the GRR in response to injury. The results indicate that NG exchanges identities between ensheathing glia (EG) and astrocyte-like glia (ALG). Additionally, we found that NG cells undergo transdifferentiation to yield neurons. Moreover, this transdifferentiation increases in injury conditions. Thus, these data demonstrate that glial cells are able to generate new neurons through direct transdifferentiation. The present work makes a fundamental contribution to the CNS regeneration field and describes a new physiological mechanism to generate new neurons.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-03-07
2025
2025-03-07
2026
2026-01-16
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/27152
url https://hdl.handle.net/20.500.12105/27152
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/zip
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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