Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle

Background: Aggressive behavior is an ancient and conserved trait, habitual for most animals in order to eat, protect themselves, compete for mating and defend their territories. Genetic factors have been shown to play an important role in the development of aggression both in animals and humans, di...

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Autores: Eusebi, Paulina G., Sevane, Natalia, O'Rourke, Thomas, Pizarro, Manuel, Boeckx, Cedric, Dunner, Susana
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/186701
Acesso em linha:https://hdl.handle.net/2445/186701
Access Level:acceso abierto
Palavra-chave:Agressivitat en els animals
Genètica de la conducta
Aggresive behavior in animals
Behavior genetics
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spelling Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattleEusebi, Paulina G.Sevane, NataliaO'Rourke, ThomasPizarro, ManuelBoeckx, CedricDunner, SusanaAgressivitat en els animalsGenètica de la conductaAggresive behavior in animalsBehavior geneticsBackground: Aggressive behavior is an ancient and conserved trait, habitual for most animals in order to eat, protect themselves, compete for mating and defend their territories. Genetic factors have been shown to play an important role in the development of aggression both in animals and humans, displaying moderate to high heritability estimates. Although such types of behaviors have been studied in different animal models, the molecular architecture of aggressiveness remains poorly understood. This study compared gene expression profiles of 16 prefrontal cortex (PFC) samples from aggressive and non-aggressive cattle breeds: Lidia, selected for agonistic responses, and Wagyu, selected for tameness. Results: A total of 918 up-regulated and 278 down-regulated differentially expressed genes (DEG) were identified, representing above-chance overlap with genes previously identified in studies of aggression across species, as well as those implicated in recent human evolution. The functional interpretation of the up-regulated genes in the aggressive cohort revealed enrichment of pathways such as Alzheimer disease-presenilin, integrins and the ERK/MAPK signaling cascade, all implicated in the development of abnormal aggressive behaviors and neurophysiological disorders. Moreover, gonadotropins, are up-regulated as natural mechanisms enhancing aggression. Concomitantly, heterotrimeric G-protein pathways, associated with low reactivity mental states, and the GAD2 gene, a repressor of agonistic reactions associated with PFC activity, are down-regulated, promoting the development of the aggressive responses selected for in Lidia cattle. We also identified six upstream regulators, whose functional activity fits with the etiology of abnormal behavioral responses associated with aggression. Conclusions: These transcriptional correlates of aggression, resulting, at least in part, from controlled artificial selection, can provide valuable insights into the complex architecture that underlies naturally developed agonistic behaviors. This analysis constitutes a first important step towards the identification of the genes and metabolic pathways that promote aggression in cattle and, providing a novel model species to disentangle the mechanisms underlying variability in aggressive behavior.BioMed Central2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/186701Articles publicats en revistes (Filologia Catalana i Lingüística General)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12864-021-07505-5Bmc Genomics, 2021, vol. 22, num. Art. n. 245, p. 1-14https://doi.org/10.1186/s12864-021-07505-5cc-by (c) Eusebi, Paulina G. et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1867012026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
title Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
spellingShingle Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
Eusebi, Paulina G.
Agressivitat en els animals
Genètica de la conducta
Aggresive behavior in animals
Behavior genetics
title_short Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
title_full Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
title_fullStr Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
title_full_unstemmed Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
title_sort Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
dc.creator.none.fl_str_mv Eusebi, Paulina G.
Sevane, Natalia
O'Rourke, Thomas
Pizarro, Manuel
Boeckx, Cedric
Dunner, Susana
author Eusebi, Paulina G.
author_facet Eusebi, Paulina G.
Sevane, Natalia
O'Rourke, Thomas
Pizarro, Manuel
Boeckx, Cedric
Dunner, Susana
author_role author
author2 Sevane, Natalia
O'Rourke, Thomas
Pizarro, Manuel
Boeckx, Cedric
Dunner, Susana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Agressivitat en els animals
Genètica de la conducta
Aggresive behavior in animals
Behavior genetics
topic Agressivitat en els animals
Genètica de la conducta
Aggresive behavior in animals
Behavior genetics
description Background: Aggressive behavior is an ancient and conserved trait, habitual for most animals in order to eat, protect themselves, compete for mating and defend their territories. Genetic factors have been shown to play an important role in the development of aggression both in animals and humans, displaying moderate to high heritability estimates. Although such types of behaviors have been studied in different animal models, the molecular architecture of aggressiveness remains poorly understood. This study compared gene expression profiles of 16 prefrontal cortex (PFC) samples from aggressive and non-aggressive cattle breeds: Lidia, selected for agonistic responses, and Wagyu, selected for tameness. Results: A total of 918 up-regulated and 278 down-regulated differentially expressed genes (DEG) were identified, representing above-chance overlap with genes previously identified in studies of aggression across species, as well as those implicated in recent human evolution. The functional interpretation of the up-regulated genes in the aggressive cohort revealed enrichment of pathways such as Alzheimer disease-presenilin, integrins and the ERK/MAPK signaling cascade, all implicated in the development of abnormal aggressive behaviors and neurophysiological disorders. Moreover, gonadotropins, are up-regulated as natural mechanisms enhancing aggression. Concomitantly, heterotrimeric G-protein pathways, associated with low reactivity mental states, and the GAD2 gene, a repressor of agonistic reactions associated with PFC activity, are down-regulated, promoting the development of the aggressive responses selected for in Lidia cattle. We also identified six upstream regulators, whose functional activity fits with the etiology of abnormal behavioral responses associated with aggression. Conclusions: These transcriptional correlates of aggression, resulting, at least in part, from controlled artificial selection, can provide valuable insights into the complex architecture that underlies naturally developed agonistic behaviors. This analysis constitutes a first important step towards the identification of the genes and metabolic pathways that promote aggression in cattle and, providing a novel model species to disentangle the mechanisms underlying variability in aggressive behavior.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186701
url https://hdl.handle.net/2445/186701
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12864-021-07505-5
Bmc Genomics, 2021, vol. 22, num. Art. n. 245, p. 1-14
https://doi.org/10.1186/s12864-021-07505-5
dc.rights.none.fl_str_mv cc-by (c) Eusebi, Paulina G. et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Eusebi, Paulina G. et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Filologia Catalana i Lingüística General)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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