Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease

In neurodegenerative diseases, neuronal dysfunction and degeneration start many years before the emergence of clinical symptoms. An important goal to advance in their knowledge and treatment is the identification of peripherical biomarkers to predict the onset and progression and to test the efficac...

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Autores: García Forn, Marta, Castany Pladevall, Carla, Golbano, Arantxa, Pérez Pérez, Jesús, Brito, Verónica, Kilisevsky, Jaime, Pérez Navarro, Ester
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218920
Acceso en línea:https://hdl.handle.net/2445/218920
Access Level:acceso abierto
Palabra clave:Medicina experimental
Corea de Huntington
Marcadors bioquímics
Experimental medicine
Huntington's chorea
Biochemical markers
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spelling Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's diseaseGarcía Forn, MartaCastany Pladevall, CarlaGolbano, ArantxaPérez Pérez, JesúsBrito, VerónicaKilisevsky, JaimePérez Navarro, EsterMedicina experimentalCorea de HuntingtonMarcadors bioquímicsExperimental medicineHuntington's choreaBiochemical markersIn neurodegenerative diseases, neuronal dysfunction and degeneration start many years before the emergence of clinical symptoms. An important goal to advance in their knowledge and treatment is the identification of peripherical biomarkers to predict the onset and progression and to test the efficacy of therapies. 1 We have previously shown that alterations in lamin B1, a member of the lamin family of proteins that are crucial for nuclear functionality, 2 are involved in the pathophysiology of Huntington's disease (HD). Specifically, lamin B1 levels are increased in the R6/1 HD mouse model at the onset of motor symptoms in striatal medium‐sized spiny and CA1 hippocampal neurons nuclei in correlation with nuclear dysfunction. 3 Therefore, we asked if increased lamin B1 levels and/or alterations in nuclear morphology could be also occurring in more accessible cells, namely fibroblasts and blood cells, and serve as biomarkers of the disease progression and/or treatment efficacy.John Wiley & Sons2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/218920Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/ctm2.1154Clinical and Translational Medicine, 2023, num.2https://doi.org/10.1002/ctm2.1154cc-by (c) Garcia-Forn M et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2189202026-05-27T06:46:51Z
dc.title.none.fl_str_mv Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
title Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
spellingShingle Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
García Forn, Marta
Medicina experimental
Corea de Huntington
Marcadors bioquímics
Experimental medicine
Huntington's chorea
Biochemical markers
title_short Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
title_full Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
title_fullStr Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
title_full_unstemmed Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
title_sort Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
dc.creator.none.fl_str_mv García Forn, Marta
Castany Pladevall, Carla
Golbano, Arantxa
Pérez Pérez, Jesús
Brito, Verónica
Kilisevsky, Jaime
Pérez Navarro, Ester
author García Forn, Marta
author_facet García Forn, Marta
Castany Pladevall, Carla
Golbano, Arantxa
Pérez Pérez, Jesús
Brito, Verónica
Kilisevsky, Jaime
Pérez Navarro, Ester
author_role author
author2 Castany Pladevall, Carla
Golbano, Arantxa
Pérez Pérez, Jesús
Brito, Verónica
Kilisevsky, Jaime
Pérez Navarro, Ester
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Medicina experimental
Corea de Huntington
Marcadors bioquímics
Experimental medicine
Huntington's chorea
Biochemical markers
topic Medicina experimental
Corea de Huntington
Marcadors bioquímics
Experimental medicine
Huntington's chorea
Biochemical markers
description In neurodegenerative diseases, neuronal dysfunction and degeneration start many years before the emergence of clinical symptoms. An important goal to advance in their knowledge and treatment is the identification of peripherical biomarkers to predict the onset and progression and to test the efficacy of therapies. 1 We have previously shown that alterations in lamin B1, a member of the lamin family of proteins that are crucial for nuclear functionality, 2 are involved in the pathophysiology of Huntington's disease (HD). Specifically, lamin B1 levels are increased in the R6/1 HD mouse model at the onset of motor symptoms in striatal medium‐sized spiny and CA1 hippocampal neurons nuclei in correlation with nuclear dysfunction. 3 Therefore, we asked if increased lamin B1 levels and/or alterations in nuclear morphology could be also occurring in more accessible cells, namely fibroblasts and blood cells, and serve as biomarkers of the disease progression and/or treatment efficacy.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/218920
url https://hdl.handle.net/2445/218920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/ctm2.1154
Clinical and Translational Medicine, 2023, num.2
https://doi.org/10.1002/ctm2.1154
dc.rights.none.fl_str_mv cc-by (c) Garcia-Forn M et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Garcia-Forn M et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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