A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy

This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.

Detalles Bibliográficos
Autores: Sánchez-Martínez, Ruth, Vargas, Teodoro, Molina, Susana, Moreno-Rubio, Juan, Reglero, Guillermo, Ramírez de Molina, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/152702
Acceso en línea:http://hdl.handle.net/10261/152702
Access Level:acceso abierto
Palabra clave:Epithelial-mesenchymal transition
Stearoyl-CoA desaturase
Colorectal cancer
Lipid metabolism
Acyl-coA synthetases
id ES_b1faaed8236e1fcd6a46d5daaf2a5b1c
oai_identifier_str oai:digital.csic.es:10261/152702
network_acronym_str ES
network_name_str España
repository_id_str
spelling A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapySánchez-Martínez, RuthVargas, TeodoroMolina, SusanaMoreno-Rubio, JuanReglero, GuillermoRamírez de Molina, AnaEpithelial-mesenchymal transitionStearoyl-CoA desaturaseColorectal cancerLipid metabolismAcyl-coA synthetasesThis is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.The alterations in carbohydrate metabolism that fuel tumor growth have been extensively studied. However, other metabolic pathways involved in malignant progression, demand further understanding. Here we describe a metabolic acyl-CoA synthetase/ stearoyl-CoA desaturase ACSL/SCD network causing an epithelial-mesenchymal transition (EMT) program that promotes migration and invasion of colon cancer cells. The mesenchymal phenotype produced upon overexpression of these enzymes is reverted through reactivation of AMPK signaling. Furthermore, this network expression correlates with poorer clinical outcome of stage-II colon cancer patients. Finally, combined treatment with chemical inhibitors of ACSL/SCD selectively decreases cancer cell viability without reducing normal cells viability. Thus, ACSL/SCD network stimulates colon cancer progression through conferring increased energetic capacity and invasive and migratory properties to cancer cells, and might represent a new therapeutic opportunity for colon cancer treatment.This work has been supported by Ministerio de Economía y Competitividad del Gobierno de España (MINECO, Plan Nacional I+D+i AGL2013-48943-C2), Gobierno regional de la Comunidad de Madrid (P2013/ABI-2728, ALIBIRD-CM) and EU Structural Funds.Peer ReviewedImpact JournalsMinisterio de Economía y Competitividad (España)Comunidad de MadridEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720152017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/152702reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#S2013/ABI-2728/ALIBIRD-CMinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013−48943-C2-1-Rhttps://doi.org/10.18632/oncotarget.5340Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1527022026-05-22T06:33:51Z
dc.title.none.fl_str_mv A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
title A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
spellingShingle A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
Sánchez-Martínez, Ruth
Epithelial-mesenchymal transition
Stearoyl-CoA desaturase
Colorectal cancer
Lipid metabolism
Acyl-coA synthetases
title_short A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
title_full A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
title_fullStr A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
title_full_unstemmed A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
title_sort A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
dc.creator.none.fl_str_mv Sánchez-Martínez, Ruth
Vargas, Teodoro
Molina, Susana
Moreno-Rubio, Juan
Reglero, Guillermo
Ramírez de Molina, Ana
author Sánchez-Martínez, Ruth
author_facet Sánchez-Martínez, Ruth
Vargas, Teodoro
Molina, Susana
Moreno-Rubio, Juan
Reglero, Guillermo
Ramírez de Molina, Ana
author_role author
author2 Vargas, Teodoro
Molina, Susana
Moreno-Rubio, Juan
Reglero, Guillermo
Ramírez de Molina, Ana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Epithelial-mesenchymal transition
Stearoyl-CoA desaturase
Colorectal cancer
Lipid metabolism
Acyl-coA synthetases
topic Epithelial-mesenchymal transition
Stearoyl-CoA desaturase
Colorectal cancer
Lipid metabolism
Acyl-coA synthetases
description This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/152702
url http://hdl.handle.net/10261/152702
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
S2013/ABI-2728/ALIBIRD-CM
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013−48943-C2-1-R
https://doi.org/10.18632/oncotarget.5340
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416996709335040
score 15.811543

Similares en LA Referencia