Clozapine use during pregnancy and lactation: A case-series report

The current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of...

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Autores: Imaz, M.Luisa, Oriolo, Giovanni, Torra, Mercè, Soy Muner, Dolors, García Esteve, Luisa, Martín-Santos Laffon, Rocío
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/154958
Acceso en línea:https://hdl.handle.net/2445/154958
Access Level:acceso abierto
Palabra clave:Embaràs
Alletament
Esquizofrènia
Pregnancy
Breastfeeding
Schizophrenia
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spelling Clozapine use during pregnancy and lactation: A case-series reportImaz, M.LuisaOriolo, GiovanniTorra, MercèSoy Muner, DolorsGarcía Esteve, LuisaMartín-Santos Laffon, RocíoEmbaràsAlletamentEsquizofrèniaPregnancyBreastfeedingSchizophreniaThe current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of clozapine that determine its passage through the placenta and amniotic fluid, as well as the neonatal clozapine elimination half-life (t1/2). This case series demonstrates for the first time that clozapine might show partial placental passage similar to other atypical antipsychotics. Clozapine levels decreased during the first few days in nursing infants. The half-life of clozapine in neonates was slightly higher than previously estimated. Clozapine use in pregnancy may be associated with diabetes mellitus, especially if there is a family history of this disease. Although no acute toxicological effects were observed in the intrauterine exposed newborn, close follow-up of pregnancy is recommended. However, these results must be taken with caution being a case series with small sample size.Frontiers Media2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/154958Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fphar.2018.00264Frontiers in Pharmacology, 2018, vol. 264, p. eCollection 20https://doi.org/10.3389/fphar.2018.00264cc-by (c) Imaz, M.Luisa et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1549582026-05-27T06:46:51Z
dc.title.none.fl_str_mv Clozapine use during pregnancy and lactation: A case-series report
title Clozapine use during pregnancy and lactation: A case-series report
spellingShingle Clozapine use during pregnancy and lactation: A case-series report
Imaz, M.Luisa
Embaràs
Alletament
Esquizofrènia
Pregnancy
Breastfeeding
Schizophrenia
title_short Clozapine use during pregnancy and lactation: A case-series report
title_full Clozapine use during pregnancy and lactation: A case-series report
title_fullStr Clozapine use during pregnancy and lactation: A case-series report
title_full_unstemmed Clozapine use during pregnancy and lactation: A case-series report
title_sort Clozapine use during pregnancy and lactation: A case-series report
dc.creator.none.fl_str_mv Imaz, M.Luisa
Oriolo, Giovanni
Torra, Mercè
Soy Muner, Dolors
García Esteve, Luisa
Martín-Santos Laffon, Rocío
author Imaz, M.Luisa
author_facet Imaz, M.Luisa
Oriolo, Giovanni
Torra, Mercè
Soy Muner, Dolors
García Esteve, Luisa
Martín-Santos Laffon, Rocío
author_role author
author2 Oriolo, Giovanni
Torra, Mercè
Soy Muner, Dolors
García Esteve, Luisa
Martín-Santos Laffon, Rocío
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Embaràs
Alletament
Esquizofrènia
Pregnancy
Breastfeeding
Schizophrenia
topic Embaràs
Alletament
Esquizofrènia
Pregnancy
Breastfeeding
Schizophrenia
description The current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of clozapine that determine its passage through the placenta and amniotic fluid, as well as the neonatal clozapine elimination half-life (t1/2). This case series demonstrates for the first time that clozapine might show partial placental passage similar to other atypical antipsychotics. Clozapine levels decreased during the first few days in nursing infants. The half-life of clozapine in neonates was slightly higher than previously estimated. Clozapine use in pregnancy may be associated with diabetes mellitus, especially if there is a family history of this disease. Although no acute toxicological effects were observed in the intrauterine exposed newborn, close follow-up of pregnancy is recommended. However, these results must be taken with caution being a case series with small sample size.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/154958
url https://hdl.handle.net/2445/154958
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fphar.2018.00264
Frontiers in Pharmacology, 2018, vol. 264, p. eCollection 20
https://doi.org/10.3389/fphar.2018.00264
dc.rights.none.fl_str_mv cc-by (c) Imaz, M.Luisa et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Imaz, M.Luisa et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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