Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells

Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into huma...

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Detalles Bibliográficos
Autores: Peralta-Garcia, Alejandro, Torrens Fontanals, Mariona, Stepniewski, Tomasz Maciej, 1988-, Grau-Expósito, Judith, Perea, David, Ayinampudi, Vikram, Waldhoer, Maria, Zimmermann, Mirjam, Buzón, María J., Genescà, Meritxell, Selent, Jana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/52352
Acceso en línea:http://hdl.handle.net/10230/52352
http://dx.doi.org/10.3390/ijms222413592
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Drug repurposing
Viral cell entry assays
Virtual screening
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spelling Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cellsPeralta-Garcia, AlejandroTorrens Fontanals, MarionaStepniewski, Tomasz Maciej, 1988-Grau-Expósito, JudithPerea, DavidAyinampudi, VikramWaldhoer, MariaZimmermann, MirjamBuzón, María J.Genescà, MeritxellSelent, JanaCOVID-19SARS-CoV-2Drug repurposingViral cell entry assaysVirtual screeningSince the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52352http://dx.doi.org/10.3390/ijms222413592reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInt J Mol Sci. 2021;22(24):13592© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/523522026-05-29T05:05:01Z
dc.title.none.fl_str_mv Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
title Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
spellingShingle Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
Peralta-Garcia, Alejandro
COVID-19
SARS-CoV-2
Drug repurposing
Viral cell entry assays
Virtual screening
title_short Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
title_full Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
title_fullStr Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
title_full_unstemmed Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
title_sort Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
dc.creator.none.fl_str_mv Peralta-Garcia, Alejandro
Torrens Fontanals, Mariona
Stepniewski, Tomasz Maciej, 1988-
Grau-Expósito, Judith
Perea, David
Ayinampudi, Vikram
Waldhoer, Maria
Zimmermann, Mirjam
Buzón, María J.
Genescà, Meritxell
Selent, Jana
author Peralta-Garcia, Alejandro
author_facet Peralta-Garcia, Alejandro
Torrens Fontanals, Mariona
Stepniewski, Tomasz Maciej, 1988-
Grau-Expósito, Judith
Perea, David
Ayinampudi, Vikram
Waldhoer, Maria
Zimmermann, Mirjam
Buzón, María J.
Genescà, Meritxell
Selent, Jana
author_role author
author2 Torrens Fontanals, Mariona
Stepniewski, Tomasz Maciej, 1988-
Grau-Expósito, Judith
Perea, David
Ayinampudi, Vikram
Waldhoer, Maria
Zimmermann, Mirjam
Buzón, María J.
Genescà, Meritxell
Selent, Jana
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
SARS-CoV-2
Drug repurposing
Viral cell entry assays
Virtual screening
topic COVID-19
SARS-CoV-2
Drug repurposing
Viral cell entry assays
Virtual screening
description Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52352
http://dx.doi.org/10.3390/ijms222413592
url http://hdl.handle.net/10230/52352
http://dx.doi.org/10.3390/ijms222413592
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Mol Sci. 2021;22(24):13592
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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