Omics in Keratoconus: From Molecular to Clinical Practice

Keratoconus (KC) is a progressive ocular disorder marked by structural and functional alterations of the cornea, leading to significant visual impairment. Recent studies indicate that these corneal changes are linked to molecular and cellular mechanisms that disrupt and degrade the extracellular mat...

Full description

Bibliographic Details
Authors: Durán Cristiano, Sandra Carolina, Bustamante Arias, Andres, Fernández, Geysson Javier, Martín Gil, Alba, Carracedo Rodríguez, Juan Gonzalo
Format: article
Publication Date:2025
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/122849
Online Access:https://hdl.handle.net/20.500.14352/122849
Access Level:Open access
Keyword:611.841.2
keratoconus
Omics
Inflammation
Transcriptomic
Exposome
Genetics
Oftalmología
3201.09 Oftalmología
id ES_b18232e2dff202604d4b9cb4c1a7709f
oai_identifier_str oai:docta.ucm.es:20.500.14352/122849
network_acronym_str ES
network_name_str España
repository_id_str
spelling Omics in Keratoconus: From Molecular to Clinical PracticeDurán Cristiano, Sandra CarolinaBustamante Arias, AndresFernández, Geysson JavierMartín Gil, AlbaCarracedo Rodríguez, Juan Gonzalo611.841.2keratoconusOmicsInflammationTranscriptomicExposomeGeneticsOftalmología3201.09 OftalmologíaKeratoconus (KC) is a progressive ocular disorder marked by structural and functional alterations of the cornea, leading to significant visual impairment. Recent studies indicate that these corneal changes are linked to molecular and cellular mechanisms that disrupt and degrade the extracellular matrix. This degradation is influenced by proteinases that contribute to a loss of homeostasis and an imbalance in the antioxidant/oxidative state within the cornea, fostering oxidative stress, inflammation, and apoptosis. Although these biological processes have been identified primarily through molecular biology research, omics technologies have significantly advanced our understanding of the physiological and pathological phenomena associated with KC. Omics studies encompassing genomics, transcriptomics, proteomics, epigenomics, and metabolomics, have emerged as critical tools in elucidating the complex biological landscape of various diseases, including ocular conditions. The integrative application of these studies has demonstrated their potential in personalizing medicine across diverse fields such as oncology, neurology, and ophthalmology. This review aims to describe findings from omics research applied to keratoconus, highlighting the genomic, transcriptomic, proteomic, epigenomic, and metabolomic aspects derived from ocular and other biological samples. Notably, the molecular insights gained from these studies hold promise for identifying biomarkers of keratoconus, which could enhance diagnostic accuracy and therapeutic strategies. The exploration of these biomarkers may facilitate improved management and treatment options for patients, contributing to personalized care in keratoconus management.MDPIUniversidad Complutense de Madrid20252025-04-0120252025-04-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/122849reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-sa/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1228492026-06-02T12:44:21Z
dc.title.none.fl_str_mv Omics in Keratoconus: From Molecular to Clinical Practice
title Omics in Keratoconus: From Molecular to Clinical Practice
spellingShingle Omics in Keratoconus: From Molecular to Clinical Practice
Durán Cristiano, Sandra Carolina
611.841.2
keratoconus
Omics
Inflammation
Transcriptomic
Exposome
Genetics
Oftalmología
3201.09 Oftalmología
title_short Omics in Keratoconus: From Molecular to Clinical Practice
title_full Omics in Keratoconus: From Molecular to Clinical Practice
title_fullStr Omics in Keratoconus: From Molecular to Clinical Practice
title_full_unstemmed Omics in Keratoconus: From Molecular to Clinical Practice
title_sort Omics in Keratoconus: From Molecular to Clinical Practice
dc.creator.none.fl_str_mv Durán Cristiano, Sandra Carolina
Bustamante Arias, Andres
Fernández, Geysson Javier
Martín Gil, Alba
Carracedo Rodríguez, Juan Gonzalo
author Durán Cristiano, Sandra Carolina
author_facet Durán Cristiano, Sandra Carolina
Bustamante Arias, Andres
Fernández, Geysson Javier
Martín Gil, Alba
Carracedo Rodríguez, Juan Gonzalo
author_role author
author2 Bustamante Arias, Andres
Fernández, Geysson Javier
Martín Gil, Alba
Carracedo Rodríguez, Juan Gonzalo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.841.2
keratoconus
Omics
Inflammation
Transcriptomic
Exposome
Genetics
Oftalmología
3201.09 Oftalmología
topic 611.841.2
keratoconus
Omics
Inflammation
Transcriptomic
Exposome
Genetics
Oftalmología
3201.09 Oftalmología
description Keratoconus (KC) is a progressive ocular disorder marked by structural and functional alterations of the cornea, leading to significant visual impairment. Recent studies indicate that these corneal changes are linked to molecular and cellular mechanisms that disrupt and degrade the extracellular matrix. This degradation is influenced by proteinases that contribute to a loss of homeostasis and an imbalance in the antioxidant/oxidative state within the cornea, fostering oxidative stress, inflammation, and apoptosis. Although these biological processes have been identified primarily through molecular biology research, omics technologies have significantly advanced our understanding of the physiological and pathological phenomena associated with KC. Omics studies encompassing genomics, transcriptomics, proteomics, epigenomics, and metabolomics, have emerged as critical tools in elucidating the complex biological landscape of various diseases, including ocular conditions. The integrative application of these studies has demonstrated their potential in personalizing medicine across diverse fields such as oncology, neurology, and ophthalmology. This review aims to describe findings from omics research applied to keratoconus, highlighting the genomic, transcriptomic, proteomic, epigenomic, and metabolomic aspects derived from ocular and other biological samples. Notably, the molecular insights gained from these studies hold promise for identifying biomarkers of keratoconus, which could enhance diagnostic accuracy and therapeutic strategies. The exploration of these biomarkers may facilitate improved management and treatment options for patients, contributing to personalized care in keratoconus management.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-04-01
2025
2025-04-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/122849
url https://hdl.handle.net/20.500.14352/122849
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416937537142784
score 15.812429

Similar Items