Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence

Bovine tuberculosis (TB), primarily caused by Mycobacterium bovis, is a chronic infectious disease of cattle with significant public health and economic implications due to its zoonotic potential and impact on livestock productivity. The control of the disease is hindered by complex epidemiological...

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Autores: Pérez de Val, Bernat|||0000-0003-3127-9182, Domingo, Mariano|||0000-0002-9623-4826, Allepuz Palau, Alberto|||0000-0003-3518-1991, Riera, Carles|||0000-0003-4406-5765, Sanz, Albert, Nofrarías Espadamala, Miquel|||0000-0002-7983-1389, López-Soria, Sergio|||0000-0001-7134-2014, Vidal Barba, Enric|||0000-0002-4965-3286
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:dnet:uabarcelona_::257f842b84b5870adf97b500e90077fc
Acesso em linha:https://ddd.uab.cat/record/327850
https://dx.doi.org/urn:doi:10.1155/tbed/2446811
Access Level:Acceso aberto
Palavra-chave:Cattle
Genomic epidemiology
Mycobacterium bovis
Residual infection
Tuberculosis
Whole genome sequencing
Wild boar
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spelling Long-Term Residual Infection as a Source of Bovine Tuberculosis ReemergenceA Phylogenetic and Epidemiological Investigation of Recurrent OutbreaksPérez de Val, Bernat|||0000-0003-3127-9182Domingo, Mariano|||0000-0002-9623-4826Allepuz Palau, Alberto|||0000-0003-3518-1991Riera, Carles|||0000-0003-4406-5765Sanz, AlbertNofrarías Espadamala, Miquel|||0000-0002-7983-1389López-Soria, Sergio|||0000-0001-7134-2014Vidal Barba, Enric|||0000-0002-4965-3286CattleGenomic epidemiologyMycobacterium bovisResidual infectionTuberculosisWhole genome sequencingWild boarBovine tuberculosis (TB), primarily caused by Mycobacterium bovis, is a chronic infectious disease of cattle with significant public health and economic implications due to its zoonotic potential and impact on livestock productivity. The control of the disease is hindered by complex epidemiological dynamics and the chronic, and often slow-progressing nature of the disease. The recurrent outbreaks of bovine TB in endemic areas are common and threaten the success of eradication programs. To address this issue, long-term reemergent outbreaks in Catalonia (Northeastern Spain) were retrospectively investigated in depth. In 2009, an outbreak caused by M. bovis spoligotype SB0120 was detected in four extensively managed cattle herds. Following intensive eradication measures, all herds recovered the officially TB-free status by 2012. In 2021, 9 years later, a new outbreak involving the same spoligotype was detected in three herds located in the same area, one of which had been affected in the previous outbreak. Extensive sampling of TB-positive slaughtered cattle and hunted wild ungulates was conducted. Whole genome sequencing (WGS) of M. bovis isolates from cattle affected in both outbreaks, as well as from two culture-positive wild boars was performed. Epidemiological and phylogenetic analyses were conducted to elucidate the origin and transmission dynamics of the outbreaks. The results revealed a long-term residual infection in the cattle herd that linked the first and second outbreaks. This herd was also the most likely source of transmission of M. bovis to wild boars. Since residual infections can jeopardize the final stages of the eradication in low-prevalence settings, thorough investigation of reemerging strains is essential for risk assessment and for guiding TB control decisions. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/327850https://dx.doi.org/urn:doi:10.1155/tbed/2446811reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Regional Development Fund INNOTUB II/EFA115/04open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::257f842b84b5870adf97b500e90077fc2026-06-06T12:50:31Z
dc.title.none.fl_str_mv Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
A Phylogenetic and Epidemiological Investigation of Recurrent Outbreaks
title Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
spellingShingle Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
Pérez de Val, Bernat|||0000-0003-3127-9182
Cattle
Genomic epidemiology
Mycobacterium bovis
Residual infection
Tuberculosis
Whole genome sequencing
Wild boar
title_short Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
title_full Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
title_fullStr Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
title_full_unstemmed Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
title_sort Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence
dc.creator.none.fl_str_mv Pérez de Val, Bernat|||0000-0003-3127-9182
Domingo, Mariano|||0000-0002-9623-4826
Allepuz Palau, Alberto|||0000-0003-3518-1991
Riera, Carles|||0000-0003-4406-5765
Sanz, Albert
Nofrarías Espadamala, Miquel|||0000-0002-7983-1389
López-Soria, Sergio|||0000-0001-7134-2014
Vidal Barba, Enric|||0000-0002-4965-3286
author Pérez de Val, Bernat|||0000-0003-3127-9182
author_facet Pérez de Val, Bernat|||0000-0003-3127-9182
Domingo, Mariano|||0000-0002-9623-4826
Allepuz Palau, Alberto|||0000-0003-3518-1991
Riera, Carles|||0000-0003-4406-5765
Sanz, Albert
Nofrarías Espadamala, Miquel|||0000-0002-7983-1389
López-Soria, Sergio|||0000-0001-7134-2014
Vidal Barba, Enric|||0000-0002-4965-3286
author_role author
author2 Domingo, Mariano|||0000-0002-9623-4826
Allepuz Palau, Alberto|||0000-0003-3518-1991
Riera, Carles|||0000-0003-4406-5765
Sanz, Albert
Nofrarías Espadamala, Miquel|||0000-0002-7983-1389
López-Soria, Sergio|||0000-0001-7134-2014
Vidal Barba, Enric|||0000-0002-4965-3286
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cattle
Genomic epidemiology
Mycobacterium bovis
Residual infection
Tuberculosis
Whole genome sequencing
Wild boar
topic Cattle
Genomic epidemiology
Mycobacterium bovis
Residual infection
Tuberculosis
Whole genome sequencing
Wild boar
description Bovine tuberculosis (TB), primarily caused by Mycobacterium bovis, is a chronic infectious disease of cattle with significant public health and economic implications due to its zoonotic potential and impact on livestock productivity. The control of the disease is hindered by complex epidemiological dynamics and the chronic, and often slow-progressing nature of the disease. The recurrent outbreaks of bovine TB in endemic areas are common and threaten the success of eradication programs. To address this issue, long-term reemergent outbreaks in Catalonia (Northeastern Spain) were retrospectively investigated in depth. In 2009, an outbreak caused by M. bovis spoligotype SB0120 was detected in four extensively managed cattle herds. Following intensive eradication measures, all herds recovered the officially TB-free status by 2012. In 2021, 9 years later, a new outbreak involving the same spoligotype was detected in three herds located in the same area, one of which had been affected in the previous outbreak. Extensive sampling of TB-positive slaughtered cattle and hunted wild ungulates was conducted. Whole genome sequencing (WGS) of M. bovis isolates from cattle affected in both outbreaks, as well as from two culture-positive wild boars was performed. Epidemiological and phylogenetic analyses were conducted to elucidate the origin and transmission dynamics of the outbreaks. The results revealed a long-term residual infection in the cattle herd that linked the first and second outbreaks. This herd was also the most likely source of transmission of M. bovis to wild boars. Since residual infections can jeopardize the final stages of the eradication in low-prevalence settings, thorough investigation of reemerging strains is essential for risk assessment and for guiding TB control decisions.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/327850
https://dx.doi.org/urn:doi:10.1155/tbed/2446811
url https://ddd.uab.cat/record/327850
https://dx.doi.org/urn:doi:10.1155/tbed/2446811
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Regional Development Fund INNOTUB II/EFA115/04
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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