Usefulness of clinical definitions of influenza for public health surveillance purposes

This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for e...

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Autores: Domínguez García, Àngela, Soldevila, Núria, Torner, Núria, Martínez, Ana, Godoy i García, Pere, Rius, Cristina, Jané, Mireia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/70062
Acceso en línea:https://doi.org/10.3390/v12010095
http://hdl.handle.net/10459.1/70062
Access Level:acceso abierto
Palabra clave:Infecció
Epidèmies
Atenció primària
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spelling Usefulness of clinical definitions of influenza for public health surveillance purposesDomínguez García, ÀngelaSoldevila, NúriaTorner, NúriaMartínez, AnaGodoy i García, PereRius, CristinaJané, MireiaInfeccióEpidèmiesAtenció primàriaThis study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for eleven years in Catalonia was conducted. Crude and adjusted diagnostic odds ratios (aDORs) and 95% confidence intervals (CIs) of the case definitions and symptoms for all weeks and epidemic weeks were estimated. The most predictive case definition for laboratory-confirmed influenza was the World Health Organization (WHO) case definition for ILI in all weeks (aDOR 2.69; 95% CI 2.42-2.99) and epidemic weeks (aDOR 2.20; 95% CI 1.90-2.54). The symptoms that were significant positive predictors for confirmed influenza were fever, cough, myalgia, headache, malaise, and sudden onset. Fever had the highest aDOR in all weeks (4.03; 95% CI 3.38-4.80) and epidemic weeks (2.78; 95% CI 2.21-3.50). All of the case definitions assessed performed better in patients with comorbidities than in those without. The performance of symptoms varied by age groups, with fever being of high value in older people, and cough being of high value in children. In patients with comorbidities, the performance of fever was the highest (aDOR 5.45; 95% CI 3.43-8.66). No differences in the performance of the case definition or symptoms in influenza cases according to virus type were found.This study was supported by the Program of Prevention, Surveillance, and Control of Transmissible Diseases (PREVICET); CIBER de Epidemiologia y Salud Publica (CIBERESP); Instituto de Salud Carlos III, Madrid; and the Catalan Agency for the Management of Grants for University Research (AGAUR Grant Number 2017/SGR 1342). The funders had no role in the study design, data collection, and analysis; the decision to publish; or preparation of the manuscript.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/v12010095http://hdl.handle.net/10459.1/70062reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.3390/v12010095Viruses, 2020, vol. 12, num. 1, p. 1-13cc-by (c) Domínguez et al., 2020info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/700622026-06-24T12:42:17Z
dc.title.none.fl_str_mv Usefulness of clinical definitions of influenza for public health surveillance purposes
title Usefulness of clinical definitions of influenza for public health surveillance purposes
spellingShingle Usefulness of clinical definitions of influenza for public health surveillance purposes
Domínguez García, Àngela
Infecció
Epidèmies
Atenció primària
title_short Usefulness of clinical definitions of influenza for public health surveillance purposes
title_full Usefulness of clinical definitions of influenza for public health surveillance purposes
title_fullStr Usefulness of clinical definitions of influenza for public health surveillance purposes
title_full_unstemmed Usefulness of clinical definitions of influenza for public health surveillance purposes
title_sort Usefulness of clinical definitions of influenza for public health surveillance purposes
dc.creator.none.fl_str_mv Domínguez García, Àngela
Soldevila, Núria
Torner, Núria
Martínez, Ana
Godoy i García, Pere
Rius, Cristina
Jané, Mireia
author Domínguez García, Àngela
author_facet Domínguez García, Àngela
Soldevila, Núria
Torner, Núria
Martínez, Ana
Godoy i García, Pere
Rius, Cristina
Jané, Mireia
author_role author
author2 Soldevila, Núria
Torner, Núria
Martínez, Ana
Godoy i García, Pere
Rius, Cristina
Jané, Mireia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Infecció
Epidèmies
Atenció primària
topic Infecció
Epidèmies
Atenció primària
description This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for eleven years in Catalonia was conducted. Crude and adjusted diagnostic odds ratios (aDORs) and 95% confidence intervals (CIs) of the case definitions and symptoms for all weeks and epidemic weeks were estimated. The most predictive case definition for laboratory-confirmed influenza was the World Health Organization (WHO) case definition for ILI in all weeks (aDOR 2.69; 95% CI 2.42-2.99) and epidemic weeks (aDOR 2.20; 95% CI 1.90-2.54). The symptoms that were significant positive predictors for confirmed influenza were fever, cough, myalgia, headache, malaise, and sudden onset. Fever had the highest aDOR in all weeks (4.03; 95% CI 3.38-4.80) and epidemic weeks (2.78; 95% CI 2.21-3.50). All of the case definitions assessed performed better in patients with comorbidities than in those without. The performance of symptoms varied by age groups, with fever being of high value in older people, and cough being of high value in children. In patients with comorbidities, the performance of fever was the highest (aDOR 5.45; 95% CI 3.43-8.66). No differences in the performance of the case definition or symptoms in influenza cases according to virus type were found.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/v12010095
http://hdl.handle.net/10459.1/70062
url https://doi.org/10.3390/v12010095
http://hdl.handle.net/10459.1/70062
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/v12010095
Viruses, 2020, vol. 12, num. 1, p. 1-13
dc.rights.none.fl_str_mv cc-by (c) Domínguez et al., 2020
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Domínguez et al., 2020
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
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repository.mail.fl_str_mv
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