Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.

[EN] Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young an...

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Autores: Díaz López, David, Sánchez Recio, Javier, Weruaga Prieto, Eduardo, Alonso Peña, José Ramón
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/168842
Acceso en línea:http://hdl.handle.net/10366/168842
Access Level:acceso abierto
Palabra clave:Cell fusion
Cerebellum
Neurorepair
Purkinje cell degeneration
Purkinje cells
Transplant
Bone Marrow Cells
Nerve Degeneration
Purkinje Cells
Stem Cell Transplantation
Cell Fusion
Animals
Neurodegenerative Diseases
Heterozygote
Aging
Mice
Stem Cells
3207.11 Neuropatología
2490 Neurociencias
cerebelo
enfermedades neurodegenerativas
trasplante de células madre
animales
ratones
células de la médula ósea
células madre
fusión celular
envejecimiento
degeneración nerviosa
células de Purkinje
heterocigoto
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.Díaz López, DavidSánchez Recio, JavierWeruaga Prieto, EduardoAlonso Peña, José RamónCell fusionCerebellumNeurorepairPurkinje cell degenerationPurkinje cellsTransplantBone Marrow CellsNerve DegenerationPurkinje CellsStem Cell TransplantationCell FusionAnimalsNeurodegenerative DiseasesCerebellumHeterozygoteAgingMiceStem Cells3207.11 Neuropatología2490 Neurocienciascerebeloenfermedades neurodegenerativastrasplante de células madreanimalesratonescélulas de la médula óseacélulas madrefusión celularenvejecimientodegeneración nerviosacélulas de Purkinjeheterocigoto[EN] Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently normal phenotype but they undergo Purkinje cell loss as they age. Our findings demonstrate that heterozygous pcd mice undergo Purkinje cell loss at postnatal day 300, this slow but steadily progressing cell death starting sooner than has been reported previously and without massive reactive gliosis or inflammation. Here, transplantation of bone marrow stem cells was performed to assess the arrival of bone marrow-derived cells in the cerebellum in these heterozygous mice. Our results reveal that a higher number of cell fusion events occurs in heterozygous animals than in the controls, on days 150 and 300 postnatally. In sum, this study indicates that mild cell death promotes the fusion of bone marrow-derived cells with surviving Purkinje neurons. This phenomenon suggests new therapies for long-lasting neurodegenerative disorders.This work was supported by the Ministerio de Investigación y Ciencia (BFU2010-18284), the Ministerio de Sanidad, Política Social e Igualdad (Plan Nacional Sobre Drogas), the Junta de Castilla y León, the Centre for Regenerative Medicine and Cell Therapy of Castilla y León, the Fundación Samuel Solórzano, and the University of Salamanca. The authors also express their gratitude to N. Skinner and C. Bruggeman for revising the English version of the manuscript. The authors declare no conflicts of interest.SAGE Publications202620262012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplicatio/pdfhttp://hdl.handle.net/10366/168842reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésBFU2010-18284Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1688422026-06-07T06:28:51Z
dc.title.none.fl_str_mv Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
title Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
spellingShingle Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
Díaz López, David
Cell fusion
Cerebellum
Neurorepair
Purkinje cell degeneration
Purkinje cells
Transplant
Bone Marrow Cells
Nerve Degeneration
Purkinje Cells
Stem Cell Transplantation
Cell Fusion
Animals
Neurodegenerative Diseases
Cerebellum
Heterozygote
Aging
Mice
Stem Cells
3207.11 Neuropatología
2490 Neurociencias
cerebelo
enfermedades neurodegenerativas
trasplante de células madre
animales
ratones
células de la médula ósea
células madre
fusión celular
envejecimiento
degeneración nerviosa
células de Purkinje
heterocigoto
title_short Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
title_full Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
title_fullStr Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
title_full_unstemmed Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
title_sort Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells.
dc.creator.none.fl_str_mv Díaz López, David
Sánchez Recio, Javier
Weruaga Prieto, Eduardo
Alonso Peña, José Ramón
author Díaz López, David
author_facet Díaz López, David
Sánchez Recio, Javier
Weruaga Prieto, Eduardo
Alonso Peña, José Ramón
author_role author
author2 Sánchez Recio, Javier
Weruaga Prieto, Eduardo
Alonso Peña, José Ramón
author2_role author
author
author
dc.subject.none.fl_str_mv Cell fusion
Cerebellum
Neurorepair
Purkinje cell degeneration
Purkinje cells
Transplant
Bone Marrow Cells
Nerve Degeneration
Purkinje Cells
Stem Cell Transplantation
Cell Fusion
Animals
Neurodegenerative Diseases
Cerebellum
Heterozygote
Aging
Mice
Stem Cells
3207.11 Neuropatología
2490 Neurociencias
cerebelo
enfermedades neurodegenerativas
trasplante de células madre
animales
ratones
células de la médula ósea
células madre
fusión celular
envejecimiento
degeneración nerviosa
células de Purkinje
heterocigoto
topic Cell fusion
Cerebellum
Neurorepair
Purkinje cell degeneration
Purkinje cells
Transplant
Bone Marrow Cells
Nerve Degeneration
Purkinje Cells
Stem Cell Transplantation
Cell Fusion
Animals
Neurodegenerative Diseases
Cerebellum
Heterozygote
Aging
Mice
Stem Cells
3207.11 Neuropatología
2490 Neurociencias
cerebelo
enfermedades neurodegenerativas
trasplante de células madre
animales
ratones
células de la médula ósea
células madre
fusión celular
envejecimiento
degeneración nerviosa
células de Purkinje
heterocigoto
description [EN] Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently normal phenotype but they undergo Purkinje cell loss as they age. Our findings demonstrate that heterozygous pcd mice undergo Purkinje cell loss at postnatal day 300, this slow but steadily progressing cell death starting sooner than has been reported previously and without massive reactive gliosis or inflammation. Here, transplantation of bone marrow stem cells was performed to assess the arrival of bone marrow-derived cells in the cerebellum in these heterozygous mice. Our results reveal that a higher number of cell fusion events occurs in heterozygous animals than in the controls, on days 150 and 300 postnatally. In sum, this study indicates that mild cell death promotes the fusion of bone marrow-derived cells with surviving Purkinje neurons. This phenomenon suggests new therapies for long-lasting neurodegenerative disorders.
publishDate 2012
dc.date.none.fl_str_mv 2012
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/168842
url http://hdl.handle.net/10366/168842
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BFU2010-18284
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv applicatio/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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