Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis

The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS)...

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Autores: Ferrer, Isidro (Ferrer Abizanda), Tuñón, Teresa, Serrano Piñol, M. Teresa, Casas, Rosaura, Alcántara Horrillo, Soledad, Zújar, M. J., Rivera, R. M.
Tipo de recurso: artículo
Fecha de publicación:1993
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/25546
Acceso en línea:https://hdl.handle.net/2445/25546
Access Level:acceso abierto
Palabra clave:Esclerosi lateral amiotròfica
Lòbul frontal
Demència
Amyotrophic lateral sclerosis
Frontal lobe
Dementia
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spelling Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosisFerrer, Isidro (Ferrer Abizanda)Tuñón, TeresaSerrano Piñol, M. TeresaCasas, RosauraAlcántara Horrillo, SoledadZújar, M. J.Rivera, R. M.Esclerosi lateral amiotròficaLòbul frontalDemènciaAmyotrophic lateral sclerosisFrontal lobeDementiaThe morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.BMJ Publishing Group1993info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/25546Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1136/jnnp.56.3.257Journal of Neurology Neurosurgery and Psychiatry, 1993, num. 56, p. 257-261http://dx.doi.org/10.1136/jnnp.56.3.257(c) British Medical Journal, 1993info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/255462026-05-27T06:46:51Z
dc.title.none.fl_str_mv Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
title Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
spellingShingle Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
Ferrer, Isidro (Ferrer Abizanda)
Esclerosi lateral amiotròfica
Lòbul frontal
Demència
Amyotrophic lateral sclerosis
Frontal lobe
Dementia
title_short Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
title_full Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
title_fullStr Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
title_full_unstemmed Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
title_sort Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
dc.creator.none.fl_str_mv Ferrer, Isidro (Ferrer Abizanda)
Tuñón, Teresa
Serrano Piñol, M. Teresa
Casas, Rosaura
Alcántara Horrillo, Soledad
Zújar, M. J.
Rivera, R. M.
author Ferrer, Isidro (Ferrer Abizanda)
author_facet Ferrer, Isidro (Ferrer Abizanda)
Tuñón, Teresa
Serrano Piñol, M. Teresa
Casas, Rosaura
Alcántara Horrillo, Soledad
Zújar, M. J.
Rivera, R. M.
author_role author
author2 Tuñón, Teresa
Serrano Piñol, M. Teresa
Casas, Rosaura
Alcántara Horrillo, Soledad
Zújar, M. J.
Rivera, R. M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosi lateral amiotròfica
Lòbul frontal
Demència
Amyotrophic lateral sclerosis
Frontal lobe
Dementia
topic Esclerosi lateral amiotròfica
Lòbul frontal
Demència
Amyotrophic lateral sclerosis
Frontal lobe
Dementia
description The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.
publishDate 1993
dc.date.none.fl_str_mv 1993
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/25546
url https://hdl.handle.net/2445/25546
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1136/jnnp.56.3.257
Journal of Neurology Neurosurgery and Psychiatry, 1993, num. 56, p. 257-261
http://dx.doi.org/10.1136/jnnp.56.3.257
dc.rights.none.fl_str_mv (c) British Medical Journal, 1993
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) British Medical Journal, 1993
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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