Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity

A new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and...

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Detalles Bibliográficos
Autores: Grau, Jordi, Montpeyó, David, Lorenzo, Julia, Roubeau, Olivier, Caubet, Amparo, Gamez, Patrick
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:136350
Acceso en línea:http://zaguan.unizar.es/record/136350
Access Level:acceso abierto
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spelling Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicityGrau, JordiMontpeyó, DavidLorenzo, JuliaRoubeau, OlivierCaubet, AmparoGamez, PatrickA new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and copper(II) nitrate, respectively. The single-crystal X-ray structure of the compounds showed that the metal centre was coordinated in a square-planar fashion by a doubly deprotonated en2ampy acting as a tetradentate mathematical equation /mathematical equation -donor ligand. DNA-binding studies revealed that 1 and 2 were electrostatically binding to DNA, probably in the grooves and cytotoxicity assays showed that the complexes were clearly more efficient than cisplatin against ovarian carcinoma (A2780) cells and the cisplatin-resistant (A2780Cis) ones.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/136350reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/AEI/PCI2021-122027-2Binfo:eu-repo/grantAgreement/ES/AEI/PID2020-115537RB-I00info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1363502026-05-29T13:59:51Z
dc.title.none.fl_str_mv Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
title Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
spellingShingle Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
Grau, Jordi
title_short Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
title_full Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
title_fullStr Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
title_full_unstemmed Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
title_sort Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
dc.creator.none.fl_str_mv Grau, Jordi
Montpeyó, David
Lorenzo, Julia
Roubeau, Olivier
Caubet, Amparo
Gamez, Patrick
author Grau, Jordi
author_facet Grau, Jordi
Montpeyó, David
Lorenzo, Julia
Roubeau, Olivier
Caubet, Amparo
Gamez, Patrick
author_role author
author2 Montpeyó, David
Lorenzo, Julia
Roubeau, Olivier
Caubet, Amparo
Gamez, Patrick
author2_role author
author
author
author
author
description A new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and copper(II) nitrate, respectively. The single-crystal X-ray structure of the compounds showed that the metal centre was coordinated in a square-planar fashion by a doubly deprotonated en2ampy acting as a tetradentate mathematical equation /mathematical equation -donor ligand. DNA-binding studies revealed that 1 and 2 were electrostatically binding to DNA, probably in the grooves and cytotoxicity assays showed that the complexes were clearly more efficient than cisplatin against ovarian carcinoma (A2780) cells and the cisplatin-resistant (A2780Cis) ones.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/136350
url http://zaguan.unizar.es/record/136350
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/AEI/PCI2021-122027-2B
info:eu-repo/grantAgreement/ES/AEI/PID2020-115537RB-I00
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
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