Emergence of assortative mixing between clusters of cultured neurons

The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuro...

Descripción completa

Detalles Bibliográficos
Autores: Teller Amado, Sara, Granell, Clara, De Domenico, M. (Manlio), 1984-, Soriano i Fradera, Jordi, Gómez, SERGIO, Arenas, Àlex
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/58593
Acceso en línea:https://hdl.handle.net/2445/58593
Access Level:acceso abierto
Palabra clave:Neurones
Xarxes neuronals (Neurobiologia)
Interacció cel·lular
Neurons
Neural networks (Neurobiology)
Cell interaction
id ES_b0ed128687eb0dca8c2dfd16b79a05ed
oai_identifier_str oai:recercat.cat:2445/58593
network_acronym_str ES
network_name_str España
repository_id_str
spelling Emergence of assortative mixing between clusters of cultured neuronsTeller Amado, SaraGranell, ClaraDe Domenico, M. (Manlio), 1984-Soriano i Fradera, JordiGómez, SERGIOArenas, ÀlexNeuronesXarxes neuronals (Neurobiologia)Interacció cel·lularNeuronsNeural networks (Neurobiology)Cell interactionThe analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuronal systems. Here, we monitor the spontaneous self-sustained dynamics in neuronal cultures formed by interconnected aggregates of neurons (clusters). Dynamics is characterized by the fast activation of groups of clusters in sequences termed bursts. The analysis of the time delays between clusters' activations within the bursts allows the reconstruction of the directed functional connectivity of the network. We propose a method to statistically infer this connectivity and analyze the resulting properties of the associated complex networks. Surprisingly enough, in contrast to what has been reported for many biological networks, the clustered neuronal cultures present assortative mixing connectivity values, meaning that there is a preference for clusters to link to other clusters that share similar functional connectivity, as well as a rich-club core, which shapes a"connectivity backbone" in the network. These results point out that the grouping of neurons and the assortative connectivity between clusters are intrinsic survival mechanisms of the culture.Public Library of Science (PLoS)2014201420142014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 p.application/pdfhttps://hdl.handle.net/2445/58593Articles publicats en revistes (Física Quàntica i Astrofísica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pcbi.1003796PLoS Computational Biology, 2014, vol. 10, num. 9, p. e100396http://dx.doi.org/10.1371/journal.pcbi.1003796info:eu-repo/grantAgreement/EC/FP7/317532cc-by (c) Teller, Sara et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/585932026-05-29T05:05:01Z
dc.title.none.fl_str_mv Emergence of assortative mixing between clusters of cultured neurons
title Emergence of assortative mixing between clusters of cultured neurons
spellingShingle Emergence of assortative mixing between clusters of cultured neurons
Teller Amado, Sara
Neurones
Xarxes neuronals (Neurobiologia)
Interacció cel·lular
Neurons
Neural networks (Neurobiology)
Cell interaction
title_short Emergence of assortative mixing between clusters of cultured neurons
title_full Emergence of assortative mixing between clusters of cultured neurons
title_fullStr Emergence of assortative mixing between clusters of cultured neurons
title_full_unstemmed Emergence of assortative mixing between clusters of cultured neurons
title_sort Emergence of assortative mixing between clusters of cultured neurons
dc.creator.none.fl_str_mv Teller Amado, Sara
Granell, Clara
De Domenico, M. (Manlio), 1984-
Soriano i Fradera, Jordi
Gómez, SERGIO
Arenas, Àlex
author Teller Amado, Sara
author_facet Teller Amado, Sara
Granell, Clara
De Domenico, M. (Manlio), 1984-
Soriano i Fradera, Jordi
Gómez, SERGIO
Arenas, Àlex
author_role author
author2 Granell, Clara
De Domenico, M. (Manlio), 1984-
Soriano i Fradera, Jordi
Gómez, SERGIO
Arenas, Àlex
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Neurones
Xarxes neuronals (Neurobiologia)
Interacció cel·lular
Neurons
Neural networks (Neurobiology)
Cell interaction
topic Neurones
Xarxes neuronals (Neurobiologia)
Interacció cel·lular
Neurons
Neural networks (Neurobiology)
Cell interaction
description The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuronal systems. Here, we monitor the spontaneous self-sustained dynamics in neuronal cultures formed by interconnected aggregates of neurons (clusters). Dynamics is characterized by the fast activation of groups of clusters in sequences termed bursts. The analysis of the time delays between clusters' activations within the bursts allows the reconstruction of the directed functional connectivity of the network. We propose a method to statistically infer this connectivity and analyze the resulting properties of the associated complex networks. Surprisingly enough, in contrast to what has been reported for many biological networks, the clustered neuronal cultures present assortative mixing connectivity values, meaning that there is a preference for clusters to link to other clusters that share similar functional connectivity, as well as a rich-club core, which shapes a"connectivity backbone" in the network. These results point out that the grouping of neurons and the assortative connectivity between clusters are intrinsic survival mechanisms of the culture.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/58593
url https://hdl.handle.net/2445/58593
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pcbi.1003796
PLoS Computational Biology, 2014, vol. 10, num. 9, p. e100396
http://dx.doi.org/10.1371/journal.pcbi.1003796
info:eu-repo/grantAgreement/EC/FP7/317532
dc.rights.none.fl_str_mv cc-by (c) Teller, Sara et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Teller, Sara et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Física Quàntica i Astrofísica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416867466051584
score 15,811543

Similares en LA Referencia