Engineered surface strategies to manage dental implant-related infections
When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant-related infections—one of the main causes of implant failure. These failures impose signifi- cant costs on patients, clinicians, and healt...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:upcommonspor::cc13cc71e2fa9520b17f28482f276f8c |
| Acceso en línea: | https://hdl.handle.net/2117/462409 https://dx.doi.org/10.1111/prd.12637 |
| Access Level: | acceso abierto |
| Palabra clave: | Antimicrobial Biomaterials Coating Dental implant Infection Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
| Sumario: | When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant-related infections—one of the main causes of implant failure. These failures impose signifi- cant costs on patients, clinicians, and healthcare systems. Despite extensive research, there is no consensus on the most effective protocol for managing peri-implantitis. Biomedical engineering has aimed to address this challenge by developing biocompat- ible implants with surface properties designed to enhance biological responses and reduce polymicrobial accumulation. Due to the complexity of interactions between implants and biological systems, no single material property can drive these pro- cesses. Instead, a combination of physical, chemical, and mechanical properties is re - quired to ensure a safe and effective response. Antimicrobial coatings are developed either by incorporating antimicrobial agents onto surfaces or modifying the material's physicochemical properties. These coatings utilize a range of compounds for contact- killing or as drug-delivery systems. While biomaterials science has advanced rapidly in enhancing implant surfaces, these bioengineering techniques have progressed more rapidly than our understanding of the pathogenesis of implant infections. To bridge this gap, biomedical engineering must address emerging knowledge about implant in- fections, focusing on controlling microbial accumulation while simultaneously manag- ing inflammatory responses to support tissue healing. This review critically evaluates current evidence on implant infection pathogenesis, antimicrobial coating technolo - gies, and systematically assesses their in vivo (animal and human evidence) efficacy to guide future advancements in implant infection mitigation. |
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