Mirror-image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity

Two chiral OsII arene iminopyridine complexes have been isolated by fractional crystallization: (SOs,SC)-[Os(η6-p-cym)(ImpyMe)I]PF6 and (ROs,RC)-[Os(η6-p-cym)(ImpyMe)I]PF6. Their X-ray structures, as well as those of the chlorido analogues, have been determined (see graphic). The complexes exhibit h...

Descripción completa

Detalles Bibliográficos
Autores: Fu, Ying, Soni, Rina, Romero Castro, María José, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin, Sadler, Peter J.
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/39325
Acceso en línea:https://hdl.handle.net/10347/39325
Access Level:acceso abierto
Palabra clave:Osmium
Organometallic
Anticancer
Chirality
Arene ligands
Descripción
Sumario:Two chiral OsII arene iminopyridine complexes have been isolated by fractional crystallization: (SOs,SC)-[Os(η6-p-cym)(ImpyMe)I]PF6 and (ROs,RC)-[Os(η6-p-cym)(ImpyMe)I]PF6. Their X-ray structures, as well as those of the chlorido analogues, have been determined (see graphic). The complexes exhibit high anticancer activity towards human ovarian, breast, and melanoma cancer cells, and have a mechanism of action distinctly different from cisplatin. They also show potential as transfer-hydrogenation catalysts for imine reduction.

Similares en LA Referencia