Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey

INTRODUCTION: Altered thyroid status exerts a major effect on the heart. Individuals with hypo- or hyperthyroidism showed various changes in electrocardiograms. However, little is known about how variations in thyroid hormone levels within the normal range affect electrical activities of the heart i...

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Detalles Bibliográficos
Autores: Zhang, Yiyi, Post, Wendy S, Cheng, Alan, Blasco-Colmenares, Elena, Tomaselli, Gordon F, Guallar, Eliseo
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7547
Acceso en línea:http://hdl.handle.net/20.500.12105/7547
Access Level:acceso abierto
Palabra clave:Female
Heart Rate
Humans
Male
Middle Aged
Thyroid Hormones
Thyrotropin
Thyroxine
Electrocardiography
Nutrition Surveys
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spelling Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination surveyZhang, YiyiPost, Wendy SCheng, AlanBlasco-Colmenares, ElenaTomaselli, Gordon FGuallar, EliseoFemaleHeart RateHumansMaleMiddle AgedThyroid HormonesThyrotropinThyroxineElectrocardiographyNutrition SurveysINTRODUCTION: Altered thyroid status exerts a major effect on the heart. Individuals with hypo- or hyperthyroidism showed various changes in electrocardiograms. However, little is known about how variations in thyroid hormone levels within the normal range affect electrical activities of the heart in the general population. METHODS AND RESULTS: We conducted a cross-sectional analysis of 5,990 men and women from the Third National Health and Nutrition Examination Survey. Serum total T4 was measured by immunoassay and TSH was measured by chemiluminescent assay. We categorized T4 and TSH into 7 groups with cut-offs at the 5(th), 20(th), 40(th), 60(th), 80(th), and 95(th) percentiles of the weighted population distribution. Electrocardiographic parameters were measured from the standard 12-lead electrocardiogram. We found a positive linear association between serum total T4 level and heart rate in men, and a U-shape association between T4 and PR interval in men and women. TSH level was positively associated with QRS interval in men, while a U-shape association between TSH and QRS was observed in women. No clear graded association between thyroid hormones and corrected QT or JT was found, except that men in the highest category of T4 levels appeared to have longer corrected QT and JT, and men in the lowest category of T4 appeared to have shorter corrected QT and JT. CONCLUSIONS: Variation in thyroid hormone levels in the general population, even within the normal range, was associated with various ECG changes.Public Library of Science (PLOS)Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)National Institutes of Health (Estados Unidos)20192019-05-0720132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7547reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/75472026-06-12T12:43:37Z
dc.title.none.fl_str_mv Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
title Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
spellingShingle Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
Zhang, Yiyi
Female
Heart Rate
Humans
Male
Middle Aged
Thyroid Hormones
Thyrotropin
Thyroxine
Electrocardiography
Nutrition Surveys
title_short Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
title_full Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
title_fullStr Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
title_full_unstemmed Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
title_sort Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey
dc.creator.none.fl_str_mv Zhang, Yiyi
Post, Wendy S
Cheng, Alan
Blasco-Colmenares, Elena
Tomaselli, Gordon F
Guallar, Eliseo
author Zhang, Yiyi
author_facet Zhang, Yiyi
Post, Wendy S
Cheng, Alan
Blasco-Colmenares, Elena
Tomaselli, Gordon F
Guallar, Eliseo
author_role author
author2 Post, Wendy S
Cheng, Alan
Blasco-Colmenares, Elena
Tomaselli, Gordon F
Guallar, Eliseo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
National Institutes of Health (Estados Unidos)
dc.subject.none.fl_str_mv Female
Heart Rate
Humans
Male
Middle Aged
Thyroid Hormones
Thyrotropin
Thyroxine
Electrocardiography
Nutrition Surveys
topic Female
Heart Rate
Humans
Male
Middle Aged
Thyroid Hormones
Thyrotropin
Thyroxine
Electrocardiography
Nutrition Surveys
description INTRODUCTION: Altered thyroid status exerts a major effect on the heart. Individuals with hypo- or hyperthyroidism showed various changes in electrocardiograms. However, little is known about how variations in thyroid hormone levels within the normal range affect electrical activities of the heart in the general population. METHODS AND RESULTS: We conducted a cross-sectional analysis of 5,990 men and women from the Third National Health and Nutrition Examination Survey. Serum total T4 was measured by immunoassay and TSH was measured by chemiluminescent assay. We categorized T4 and TSH into 7 groups with cut-offs at the 5(th), 20(th), 40(th), 60(th), 80(th), and 95(th) percentiles of the weighted population distribution. Electrocardiographic parameters were measured from the standard 12-lead electrocardiogram. We found a positive linear association between serum total T4 level and heart rate in men, and a U-shape association between T4 and PR interval in men and women. TSH level was positively associated with QRS interval in men, while a U-shape association between TSH and QRS was observed in women. No clear graded association between thyroid hormones and corrected QT or JT was found, except that men in the highest category of T4 levels appeared to have longer corrected QT and JT, and men in the lowest category of T4 appeared to have shorter corrected QT and JT. CONCLUSIONS: Variation in thyroid hormone levels in the general population, even within the normal range, was associated with various ECG changes.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01
2013
2013-01-01
2019
2019-05-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7547
url http://hdl.handle.net/20.500.12105/7547
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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