Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies

Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of insoluble protein aggregates with amyloid conformation inside bacteri...

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Detalles Bibliográficos
Autores: Caballero Hernández, Ana Belén, Gámez Enamorado, Patrick, Sabaté Lagunas, Raimon, Espargaró Colomé, Alba
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/194018
Acceso en línea:https://hdl.handle.net/2445/194018
Access Level:acceso abierto
Palabra clave:Amiloïdosi
Malaltia d'Alzheimer
Amyloidosis
Alzheimer's disease
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spelling Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion BodiesCaballero Hernández, Ana BelénGámez Enamorado, PatrickSabaté Lagunas, RaimonEspargaró Colomé, AlbaAmiloïdosiMalaltia d'AlzheimerAmyloidosisAlzheimer's diseaseAmyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of insoluble protein aggregates with amyloid conformation inside bacteria, namely, in bacterial inclusion bodies, offers the possibility to use bacteria as simple models to study amyloid aggregation processes and potential effects of both anti-amyloid drugs and/or pro-aggregative compounds. This chapter describes fast, simple, inexpensive, highly reproducible, and tunable in vitro and in cellulo methods that use bacterial inclusion bodies as preliminary screening tools for anti-amyloid drugs. Keywords: Amyloid aggregation; Bacterial inclusion body; Conformational disease; Drug screening.Springer Science + Business Media2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion24 p.application/pdfhttps://hdl.handle.net/2445/194018Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1007/978-1-0716-2529-3_12Methods in Molecular Biology, 2022, vol. 2538, p. 165-188https://doi.org/10.1007/978-1-0716-2529-3_12(c) Springer Science + Business Media, 2022info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1940182026-05-29T05:05:01Z
dc.title.none.fl_str_mv Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
title Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
spellingShingle Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
Caballero Hernández, Ana Belén
Amiloïdosi
Malaltia d'Alzheimer
Amyloidosis
Alzheimer's disease
title_short Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
title_full Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
title_fullStr Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
title_full_unstemmed Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
title_sort Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
dc.creator.none.fl_str_mv Caballero Hernández, Ana Belén
Gámez Enamorado, Patrick
Sabaté Lagunas, Raimon
Espargaró Colomé, Alba
author Caballero Hernández, Ana Belén
author_facet Caballero Hernández, Ana Belén
Gámez Enamorado, Patrick
Sabaté Lagunas, Raimon
Espargaró Colomé, Alba
author_role author
author2 Gámez Enamorado, Patrick
Sabaté Lagunas, Raimon
Espargaró Colomé, Alba
author2_role author
author
author
dc.subject.none.fl_str_mv Amiloïdosi
Malaltia d'Alzheimer
Amyloidosis
Alzheimer's disease
topic Amiloïdosi
Malaltia d'Alzheimer
Amyloidosis
Alzheimer's disease
description Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of insoluble protein aggregates with amyloid conformation inside bacteria, namely, in bacterial inclusion bodies, offers the possibility to use bacteria as simple models to study amyloid aggregation processes and potential effects of both anti-amyloid drugs and/or pro-aggregative compounds. This chapter describes fast, simple, inexpensive, highly reproducible, and tunable in vitro and in cellulo methods that use bacterial inclusion bodies as preliminary screening tools for anti-amyloid drugs. Keywords: Amyloid aggregation; Bacterial inclusion body; Conformational disease; Drug screening.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/194018
url https://hdl.handle.net/2445/194018
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/978-1-0716-2529-3_12
Methods in Molecular Biology, 2022, vol. 2538, p. 165-188
https://doi.org/10.1007/978-1-0716-2529-3_12
dc.rights.none.fl_str_mv (c) Springer Science + Business Media, 2022
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Science + Business Media, 2022
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Science + Business Media
publisher.none.fl_str_mv Springer Science + Business Media
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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