Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)

López De Andrés, Ana Isabel; López Herranz, Marta; Hernández Barrera, Valentín; Miguel Díez, Javier De; Miguel Yanes, José María De; Carabantes Alarcón, David; Albaladejo Vicente, Romana; Villanueva Orbaiz, M. Rosa Rita; Jiménez García, Rodrigo

Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)

Background: To analyze the incidence, clinical characteristics, use of procedures, and in-hospital outcomes in patients who developed pneumonia during their hospital admission according to sex and to the presence of type 2 diabetes mellitus (T2DM). (2) Methods: Retrospective cohort study using data...

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Detalhes bibliográficos
Autores:	López De Andrés, Ana Isabel, López Herranz, Marta, Hernández Barrera, Valentín, Miguel Díez, Javier De, Miguel Yanes, José María De, Carabantes Alarcón, David, Albaladejo Vicente, Romana, Villanueva Orbaiz, M. Rosa Rita, Jiménez García, Rodrigo
Tipo de documento:	artigo
Data de publicação:	2021
País:	España
Recursos:	Universidad Complutense de Madrid (UCM)
Repositório:	Docta Complutense
Idioma:	inglês
OAI Identifier:	oai:docta.ucm.es:20.500.14352/5067
Acesso em linha:	https://hdl.handle.net/20.500.14352/5067
Access Level:	Acceso aberto
Palavra-chave:	616.24-002 616.379-008.64 Hospital-acquired pneumonia Ventilator-associated pneumonia Type 2 diabetes mellitus Hospitalizations Sex differences Outcomes Medicina Gastroenterología y hepatología Inmunología Neumología 32 Ciencias Médicas 3205.03 Gastroenterología 2412 Inmunología 3205.08 Enfermedades Pulmonares

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spelling	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)López De Andrés, Ana IsabelLópez Herranz, MartaHernández Barrera, ValentínMiguel Díez, Javier DeMiguel Yanes, José María DeCarabantes Alarcón, DavidAlbaladejo Vicente, RomanaVillanueva Orbaiz, M. Rosa RitaJiménez García, Rodrigo616.24-002616.379-008.64Hospital-acquired pneumoniaVentilator-associated pneumoniaType 2 diabetes mellitusHospitalizationsSex differencesOutcomesMedicinaGastroenterología y hepatologíaInmunologíaNeumología32 Ciencias Médicas3205.03 Gastroenterología2412 Inmunología3205.08 Enfermedades PulmonaresBackground: To analyze the incidence, clinical characteristics, use of procedures, and in-hospital outcomes in patients who developed pneumonia during their hospital admission according to sex and to the presence of type 2 diabetes mellitus (T2DM). (2) Methods: Retrospective cohort study using data from the Spanish National Hospital Discharge Database. Hospital-acquired pneumonia (HAP) was classed as non-ventilator HAP and ventilator-associated pneumonia (VAP). Separate analyses were performed for men and women with and without T2DM. Population subgroups were compared using propensity score matching. (3) Results: HAP was identified in 38,814 patients (24.07% with T2DM). The adjusted incidence of HAP was higher in patients with T2DM (both sexes) (IRR 1.28; 95% CI 1.25–1.31). The incidence of HAP was higher in men with T2DM than in women with T2DM (adjusted-IR 1.47; 95% CI 1.41–1.53). The incidence of HAP among T2DM patients increased over time. In-hospital mortality (IHM) was around 28% irrespective of T2DM status and sex. After adjusting for confounders and sex, VAP was associated to higher IHM among patients with T2DM (OR 2.09; 95% CI 1.7–2.57). (4) Conclusions: T2DM is associated with a higher risk of HAP, whose incidence increased over time. Men with T2DM have an almost 50% higher risk of HAP than women with T2DM. The probability of dying in the hospital was not associated with sex or T2DM.MDPIUniversidad Complutense de Madrid20212021-11-3020212021-11-30journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/5067reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/50672026-06-02T12:44:21Z
dc.title.none.fl_str_mv	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
title	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
spellingShingle	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019) López De Andrés, Ana Isabel 616.24-002 616.379-008.64 Hospital-acquired pneumonia Ventilator-associated pneumonia Type 2 diabetes mellitus Hospitalizations Sex differences Outcomes Medicina Gastroenterología y hepatología Inmunología Neumología 32 Ciencias Médicas 3205.03 Gastroenterología 2412 Inmunología 3205.08 Enfermedades Pulmonares
title_short	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
title_full	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
title_fullStr	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
title_full_unstemmed	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
title_sort	Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)
dc.creator.none.fl_str_mv	López De Andrés, Ana Isabel López Herranz, Marta Hernández Barrera, Valentín Miguel Díez, Javier De Miguel Yanes, José María De Carabantes Alarcón, David Albaladejo Vicente, Romana Villanueva Orbaiz, M. Rosa Rita Jiménez García, Rodrigo
author	López De Andrés, Ana Isabel
author_facet	López De Andrés, Ana Isabel López Herranz, Marta Hernández Barrera, Valentín Miguel Díez, Javier De Miguel Yanes, José María De Carabantes Alarcón, David Albaladejo Vicente, Romana Villanueva Orbaiz, M. Rosa Rita Jiménez García, Rodrigo
author_role	author
author2	López Herranz, Marta Hernández Barrera, Valentín Miguel Díez, Javier De Miguel Yanes, José María De Carabantes Alarcón, David Albaladejo Vicente, Romana Villanueva Orbaiz, M. Rosa Rita Jiménez García, Rodrigo
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv	Universidad Complutense de Madrid
dc.subject.none.fl_str_mv	616.24-002 616.379-008.64 Hospital-acquired pneumonia Ventilator-associated pneumonia Type 2 diabetes mellitus Hospitalizations Sex differences Outcomes Medicina Gastroenterología y hepatología Inmunología Neumología 32 Ciencias Médicas 3205.03 Gastroenterología 2412 Inmunología 3205.08 Enfermedades Pulmonares
topic	616.24-002 616.379-008.64 Hospital-acquired pneumonia Ventilator-associated pneumonia Type 2 diabetes mellitus Hospitalizations Sex differences Outcomes Medicina Gastroenterología y hepatología Inmunología Neumología 32 Ciencias Médicas 3205.03 Gastroenterología 2412 Inmunología 3205.08 Enfermedades Pulmonares
description	Background: To analyze the incidence, clinical characteristics, use of procedures, and in-hospital outcomes in patients who developed pneumonia during their hospital admission according to sex and to the presence of type 2 diabetes mellitus (T2DM). (2) Methods: Retrospective cohort study using data from the Spanish National Hospital Discharge Database. Hospital-acquired pneumonia (HAP) was classed as non-ventilator HAP and ventilator-associated pneumonia (VAP). Separate analyses were performed for men and women with and without T2DM. Population subgroups were compared using propensity score matching. (3) Results: HAP was identified in 38,814 patients (24.07% with T2DM). The adjusted incidence of HAP was higher in patients with T2DM (both sexes) (IRR 1.28; 95% CI 1.25–1.31). The incidence of HAP was higher in men with T2DM than in women with T2DM (adjusted-IR 1.47; 95% CI 1.41–1.53). The incidence of HAP among T2DM patients increased over time. In-hospital mortality (IHM) was around 28% irrespective of T2DM status and sex. After adjusting for confounders and sex, VAP was associated to higher IHM among patients with T2DM (OR 2.09; 95% CI 1.7–2.57). (4) Conclusions: T2DM is associated with a higher risk of HAP, whose incidence increased over time. Men with T2DM have an almost 50% higher risk of HAP than women with T2DM. The probability of dying in the hospital was not associated with sex or T2DM.
publishDate	2021
dc.date.none.fl_str_mv	2021 2021-11-30 2021 2021-11-30
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.14352/5067
url	https://hdl.handle.net/20.500.14352/5067
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM)
instname_str	Universidad Complutense de Madrid (UCM)
reponame_str	Docta Complutense
collection	Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Sex Differences in Hospital-Acquired Pneumonia among Patients with Type 2 Diabetes Mellitus Patients: Retrospective Cohort Study using Hospital Discharge Data in Spain (2016–2019)

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