Replication-transcription symbiosis in the mammalian nucleus: The art of living together

Similarly to life in our planet, where thousands of species inhabit the same ecosystem, the cell nucleus hosts different essential processes that share the same territory, making the interaction between them unavoidable. DNA replication and transcription are essential processes that copy and decode...

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Detalles Bibliográficos
Autores: Segura, Joana, Gómez, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/424350
Acceso en línea:http://hdl.handle.net/10261/424350
Access Level:acceso abierto
Palabra clave:DNA replication
transcription
chromatin
histones
RNAPII
nucleosomes
replisome
PTMs
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spelling Replication-transcription symbiosis in the mammalian nucleus: The art of living togetherSegura, JoanaGómez, MaríaDNA replicationtranscriptionchromatinhistonesRNAPIInucleosomesreplisomePTMsSimilarly to life in our planet, where thousands of species inhabit the same ecosystem, the cell nucleus hosts different essential processes that share the same territory, making the interaction between them unavoidable. DNA replication and transcription are essential processes that copy and decode the information contained in our genomes, sharing -and competing for- the same chromatin template. Both activities are executed by large macromolecular machines with similar requirements to access the DNA, remodel the nucleosomes ahead of them and reassemble the chromatin make-up behind. Mechanistically, both processes cannot simultaneously act on the same DNA sequence, but emerging evidence shows that they frequently interact. Here we revise recent data on how transcription and replication occur in chromatin highlighting the symbiotic relationship between both processes, which might help explain how their activities contribute to shape the structure and function of the mammalian genome.This research was funded by MCIN/AEI/10.13039/501100011033/FEDER grant number PID2022-141380NB-I00. Support from CSIC 2023AEP011 is also acknowledged. J.S. is supported by MCIN/AEI/10.13039/501100011033 and European Union « NextGenerationEU»/PRTR grant number FJC2021-047498-I.Ministerio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2026202620252026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/424350reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141380NB-I00http://dx.doi.org/10.1016/j.ceb.2025.102479Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4243502026-05-22T06:33:51Z
dc.title.none.fl_str_mv Replication-transcription symbiosis in the mammalian nucleus: The art of living together
title Replication-transcription symbiosis in the mammalian nucleus: The art of living together
spellingShingle Replication-transcription symbiosis in the mammalian nucleus: The art of living together
Segura, Joana
DNA replication
transcription
chromatin
histones
RNAPII
nucleosomes
replisome
PTMs
title_short Replication-transcription symbiosis in the mammalian nucleus: The art of living together
title_full Replication-transcription symbiosis in the mammalian nucleus: The art of living together
title_fullStr Replication-transcription symbiosis in the mammalian nucleus: The art of living together
title_full_unstemmed Replication-transcription symbiosis in the mammalian nucleus: The art of living together
title_sort Replication-transcription symbiosis in the mammalian nucleus: The art of living together
dc.creator.none.fl_str_mv Segura, Joana
Gómez, María
author Segura, Joana
author_facet Segura, Joana
Gómez, María
author_role author
author2 Gómez, María
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv DNA replication
transcription
chromatin
histones
RNAPII
nucleosomes
replisome
PTMs
topic DNA replication
transcription
chromatin
histones
RNAPII
nucleosomes
replisome
PTMs
description Similarly to life in our planet, where thousands of species inhabit the same ecosystem, the cell nucleus hosts different essential processes that share the same territory, making the interaction between them unavoidable. DNA replication and transcription are essential processes that copy and decode the information contained in our genomes, sharing -and competing for- the same chromatin template. Both activities are executed by large macromolecular machines with similar requirements to access the DNA, remodel the nucleosomes ahead of them and reassemble the chromatin make-up behind. Mechanistically, both processes cannot simultaneously act on the same DNA sequence, but emerging evidence shows that they frequently interact. Here we revise recent data on how transcription and replication occur in chromatin highlighting the symbiotic relationship between both processes, which might help explain how their activities contribute to shape the structure and function of the mammalian genome.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/424350
url http://hdl.handle.net/10261/424350
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141380NB-I00
http://dx.doi.org/10.1016/j.ceb.2025.102479
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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