Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the tre...

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Autores: González Rodríguez, Alexandre, Haba Rubio, José, Usall i Rodié, Judith, Natividad, Mentxu, Soria, Virginia, Labad, Javier, Monreal, José Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/185036
Acceso en línea:https://hdl.handle.net/2445/185036
Access Level:acceso abierto
Palabra clave:Trastorns del son
Menopausa
Esquizofrènia
Sleep disorders
Menopause
Schizophrenia
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spelling Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative ReviewGonzález Rodríguez, AlexandreHaba Rubio, JoséUsall i Rodié, JudithNatividad, MentxuSoria, VirginiaLabad, JavierMonreal, José AntonioTrastorns del sonMenopausaEsquizofrèniaSleep disordersMenopauseSchizophreniaWhile the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.MDPI AG2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185036Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/clockssleep4010007Clocks & Sleep, 2022, vol. 4, num. 1, p. 52-65https://doi.org/10.3390/clockssleep4010007cc by (c) González Rodríguez, Alexandre et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1850362026-05-27T06:46:51Z
dc.title.none.fl_str_mv Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
title Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
spellingShingle Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
González Rodríguez, Alexandre
Trastorns del son
Menopausa
Esquizofrènia
Sleep disorders
Menopause
Schizophrenia
title_short Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
title_full Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
title_fullStr Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
title_full_unstemmed Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
title_sort Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
dc.creator.none.fl_str_mv González Rodríguez, Alexandre
Haba Rubio, José
Usall i Rodié, Judith
Natividad, Mentxu
Soria, Virginia
Labad, Javier
Monreal, José Antonio
author González Rodríguez, Alexandre
author_facet González Rodríguez, Alexandre
Haba Rubio, José
Usall i Rodié, Judith
Natividad, Mentxu
Soria, Virginia
Labad, Javier
Monreal, José Antonio
author_role author
author2 Haba Rubio, José
Usall i Rodié, Judith
Natividad, Mentxu
Soria, Virginia
Labad, Javier
Monreal, José Antonio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorns del son
Menopausa
Esquizofrènia
Sleep disorders
Menopause
Schizophrenia
topic Trastorns del son
Menopausa
Esquizofrènia
Sleep disorders
Menopause
Schizophrenia
description While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185036
url https://hdl.handle.net/2445/185036
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/clockssleep4010007
Clocks & Sleep, 2022, vol. 4, num. 1, p. 52-65
https://doi.org/10.3390/clockssleep4010007
dc.rights.none.fl_str_mv cc by (c) González Rodríguez, Alexandre et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) González Rodríguez, Alexandre et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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