Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex

Over the past decade, the number of experimental and clinical studies using theta-burststimulation (TBS) protocols of transcranial magnetic stimulation (TMS) to modulate brain activity has risen substantially. The use of TBS is motivated by the assumption that these protocols can reliably and lastin...

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Autores: Ozdemir, Recep A.|||0000-0003-2832-1300, Boucher, Pierre, Fried, Peter J., Momi, Davide, Jannati, Ali, Pascual Leone, Álvaro|||0000-0001-8975-0382, Santarnecchi, Emiliano|||0000-0002-6533-7427, Shafi, Mouhsin M.
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:250431
Acceso en línea:https://ddd.uab.cat/record/250431
https://dx.doi.org/urn:doi:10.1016/j.brs.2021.05.013
Access Level:acceso abierto
Palabra clave:TMS-EEG
Theta burst stimulation
Transcranial evoked potentials (TEPs)
Reliability
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spelling Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortexOzdemir, Recep A.|||0000-0003-2832-1300Boucher, PierreFried, Peter J.Momi, DavideJannati, AliPascual Leone, Álvaro|||0000-0001-8975-0382Santarnecchi, Emiliano|||0000-0002-6533-7427Shafi, Mouhsin M.TMS-EEGTheta burst stimulationTranscranial evoked potentials (TEPs)ReliabilityOver the past decade, the number of experimental and clinical studies using theta-burststimulation (TBS) protocols of transcranial magnetic stimulation (TMS) to modulate brain activity has risen substantially. The use of TBS is motivated by the assumption that these protocols can reliably and lastingly modulate cortical excitability despite their short duration and low number of stimuli. However, this assumption, and thus the experimental validity of studies using TBS, is challenged by recent work showing large inter- and intra-subject variability in response to TBS protocols. To date, the reproducibility of TBS effects in humans has been exclusively assessed with motor evoked potentials (MEPs), which provide an indirect and limited measure of cortical excitability. Here we combined TMS with electroencephalography (TMS-EEG) and report the first comprehensive investigation of (1) direct TMS-evoked cortical responses to intermittent (iTBS) and continuous TBS (cTBS) of the human motor cortex, and (2) reproducibility of both iTBS- and cTBS-induced cortical response modulation against a robust sham control across repeat visits with commonly used cortical responsivity metrics. We show that although single pulse TMS generates stable and reproducible cortical responses across visits, the modulatory effects of TBS vary substantially both between and within individuals. Overall, at the group level, most measures of the iTBS and cTBS-induced effects were not significantly different from sham-TBS. Most importantly, none of the significant TBS-induced effects observed in visit1 were reproduced in visit-2. Our findings suggest that the generally accepted mechanisms of TBS-induced neuromodulation, i.e. through changes in cortical excitability, may not be accurate. Future research is needed to determine the mechanisms underlying the established therapeutic effects of TBS in neuropsychiatry and examine reproducibility of TBS-induced neuromodulation through oscillatory response dynamics. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/250431https://dx.doi.org/urn:doi:10.1016/j.brs.2021.05.013reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2504312026-06-06T12:50:31Z
dc.title.none.fl_str_mv Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
title Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
spellingShingle Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
Ozdemir, Recep A.|||0000-0003-2832-1300
TMS-EEG
Theta burst stimulation
Transcranial evoked potentials (TEPs)
Reliability
title_short Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
title_full Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
title_fullStr Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
title_full_unstemmed Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
title_sort Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex
dc.creator.none.fl_str_mv Ozdemir, Recep A.|||0000-0003-2832-1300
Boucher, Pierre
Fried, Peter J.
Momi, Davide
Jannati, Ali
Pascual Leone, Álvaro|||0000-0001-8975-0382
Santarnecchi, Emiliano|||0000-0002-6533-7427
Shafi, Mouhsin M.
author Ozdemir, Recep A.|||0000-0003-2832-1300
author_facet Ozdemir, Recep A.|||0000-0003-2832-1300
Boucher, Pierre
Fried, Peter J.
Momi, Davide
Jannati, Ali
Pascual Leone, Álvaro|||0000-0001-8975-0382
Santarnecchi, Emiliano|||0000-0002-6533-7427
Shafi, Mouhsin M.
author_role author
author2 Boucher, Pierre
Fried, Peter J.
Momi, Davide
Jannati, Ali
Pascual Leone, Álvaro|||0000-0001-8975-0382
Santarnecchi, Emiliano|||0000-0002-6533-7427
Shafi, Mouhsin M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TMS-EEG
Theta burst stimulation
Transcranial evoked potentials (TEPs)
Reliability
topic TMS-EEG
Theta burst stimulation
Transcranial evoked potentials (TEPs)
Reliability
description Over the past decade, the number of experimental and clinical studies using theta-burststimulation (TBS) protocols of transcranial magnetic stimulation (TMS) to modulate brain activity has risen substantially. The use of TBS is motivated by the assumption that these protocols can reliably and lastingly modulate cortical excitability despite their short duration and low number of stimuli. However, this assumption, and thus the experimental validity of studies using TBS, is challenged by recent work showing large inter- and intra-subject variability in response to TBS protocols. To date, the reproducibility of TBS effects in humans has been exclusively assessed with motor evoked potentials (MEPs), which provide an indirect and limited measure of cortical excitability. Here we combined TMS with electroencephalography (TMS-EEG) and report the first comprehensive investigation of (1) direct TMS-evoked cortical responses to intermittent (iTBS) and continuous TBS (cTBS) of the human motor cortex, and (2) reproducibility of both iTBS- and cTBS-induced cortical response modulation against a robust sham control across repeat visits with commonly used cortical responsivity metrics. We show that although single pulse TMS generates stable and reproducible cortical responses across visits, the modulatory effects of TBS vary substantially both between and within individuals. Overall, at the group level, most measures of the iTBS and cTBS-induced effects were not significantly different from sham-TBS. Most importantly, none of the significant TBS-induced effects observed in visit1 were reproduced in visit-2. Our findings suggest that the generally accepted mechanisms of TBS-induced neuromodulation, i.e. through changes in cortical excitability, may not be accurate. Future research is needed to determine the mechanisms underlying the established therapeutic effects of TBS in neuropsychiatry and examine reproducibility of TBS-induced neuromodulation through oscillatory response dynamics.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/250431
https://dx.doi.org/urn:doi:10.1016/j.brs.2021.05.013
url https://ddd.uab.cat/record/250431
https://dx.doi.org/urn:doi:10.1016/j.brs.2021.05.013
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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