Theophylline is able to partially revert cachexia in tumour-bearing rats

Background and aims: the aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia. Methods: the in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submit...

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Detalles Bibliográficos
Autores: Olivan Riera, Mireia, Springer, Jochen, Busquets Rius, Sílvia, Tschirner, Anika, Figueras, Maite, Toledo Soler, Miriam, Fontes de Oliveira, Cibely Cristine, Genovese, Maria Inês, Ventura da Silva, Paula, Sette, Angelica, López-Soriano, Francisco J., Anker, Stefan, Argilés Huguet, Josep Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/168103
Acceso en línea:https://hdl.handle.net/2445/168103
Access Level:acceso abierto
Palabra clave:Teofil·lina
Caquèxia
Ratolins (Animals de laboratori)
Theophylline
Cachexia
Mice (Laboratory animals)
Descripción
Sumario:Background and aims: the aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia. Methods: the in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment. Results: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function. Conclusion: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.

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